OVARIAN CANCER OVARIAN TUMOURS Definition Ovarian tumors may

OVARIAN CANCER

OVARIAN TUMOURS Definition Ovarian tumors may arise at any age, but are commonest between 30 and 60. 1. Ovarian tumors are particularly liable to be or to become malignant. 2. In their early stages they are asymptomatic and painless. 3. They may grow to a large size and tend to undergo mechanical complications such as torsion and perforation. 2003 -10 -27 Ovarian Cancer 2

CARCINOMA OF THE OVARY Definition In developed countries，women have a lifetime risk of developing ovarian cancer of about 1. 4%，which is slightly greater than the risk of cervical or endometrial cancers, but well below the 7% average risk of breast cancer． 2003 -10 -27 Ovarian Cancer 3

CARCINOMA OF THE OVARY Risk Factor Genetic factor are sometimes involved、 as in the Lynch Syndrome of familial breast colorectal and ovarian cancer．Ovulation induction with Clomiphene over more than year carries a l 0 -fold increased risk of ovarian cancer, Long-term ora 1 contraceptive use reduces the incidence of ovarian cancers． 2003 -10 -27 Ovarian Cancer 4

CARCINOMA OF THE OVARY Incidence Nearly 25% of all ovarian neoplasm are malignant．Approximately 80％ of them are primary growths of the ovary、the remainder being secondary，usually carcinomata． 2003 -10 -27 Ovarian Cancer 5

CARCINOMA OF THE OVARY Primary Carcinoma of the Ovary 80％ of all cases of primary carcinoma of the ovary arise in serous or mucinous cysts. 2003 -10 -27 Ovarian Cancer 6

CARCINOMA OF THE OVARY Solid Carcinoma of the Ovary This accounts for 10% of primary carcinoma. It is arise commonly bilateral but one tumor is usually larger than the other. The ovarian shape is retained for a time and there is a well-marked pedicle but soon the tumors become fixed. Secondary deposits occur in the omentum and ascites develops. 2003 -10 -27 Ovarian Cancer 7

CLINICAL FEATURES OF OVARIAN TUMOURS Symptoms due to Size Lack of any specific symptoms, ovarian tumors are often large by the time the doctor is consulted. 2003 -10 -27 Ovarian Cancer 8

Menstrual function is seldom upset, and any irregularity is attributed to the patient’s ‘time of life’. 2003 -10 -27 Ovarian Cancer 9

She may have noticed that her clothes are getting tight ant attributed this to weight gain or, if the abdominal swelling has coincided with amenorrhea she may believe herself to be pregnant. 2003 -10 -27 Ovarian Cancer 10

CLINICAL FEATURES OF OVARIAN TUMOURS Pressure Symptoms These are commonly increased frequency of micturition, gastrointestinal symptoms and a dull pain in the lower abdomen. Very large tumors may cause respiratory embarrassment and edema or varicosities in the legs, and a characteristic ‘ ovarian cachexia’ develops, due perhaps to interference with alimentary function. 2003 -10 -27 Ovarian Cancer 11

CLINICAL FEATURES OF OVARIAN TUMOURS 2003 -10 -27 Ovarian Cancer 12

CLINICAL FEATURES OF OVARIAN TUMOURS 2003 -10 -27 Ovarian Cancer 13

CLINICAL FEATURES OF OVARIAN TUMOURS 2003 -10 -27 Ovarian Cancer 14

CLINICAL FEATURES OF OVARIAN TUMOURS 2003 -10 -27 Ovarian Cancer 15

DIFFERENTIAL DIAGNOSIS General rule An experienced examiner will recognize an ovarian tumor mainly because ovarian tumor is, in the circumstances, the most likely diagnosis. All abdominal swellings should be subjected to ultrasound and X-ray examination. 2003 -10 -27 Ovarian Cancer 16

DIFFERENTIAL DIAGNOSIS 2003 -10 -27 Ovarian Cancer 17

DIFFERENTIAL DIAGNOSIS ASCITES A fluid thrill may be elicited from an ovarian cyst, and ascites and tumor may coexist; but as a rule the distinction should be easily made. 2003 -10 -27 Ovarian Cancer 18

DIFFERENTIAL DIAGNOSIS 2003 -10 -27 Ovarian Cancer 19

DIFFERENTIAL DIAGNOSIS Uterine Fibroids A large midline intramural fibroid may be impossible to distinguish from a solid ovarian tumor until the abdomen is opened an entirely different surgical problem encountered. 2003 -10 -27 Ovarian Cancer 20

DIFFERENTIAL DIAGNOSIS 2003 -10 -27 Ovarian Cancer 21

DIFFERENTIAL DIAGNOSIS 2003 -10 -27 Ovarian Cancer 22

DIFFERENTIAL DIAGNOSIS 2003 -10 -27 Ovarian Cancer 23

DIFFERENTIAL DIAGNOSIS 2003 -10 -27 Ovarian Cancer 24

DIFFERENTIAL DIAGNOSIS 2003 -10 -27 Ovarian Cancer 25

TORSION of the PEDICLE Complications of Ovarian Tumors This is the commonest complication and may occur with any tumor except those with adhesions. The thin-walled veins of the pedicle are obstructed first while the arterial supply continues. As a result there is hemorrhage into the tumor and into the peritoneum, and if not treated gangrene will occur. Very rarely the pedicle atrophies and the tumor obtains a new blood supply through its adhesions to surrounding viscera (parasitic tumor). 2003 -10 -27 Ovarian Cancer 26

TORSION of the PEDICLE 2003 -10 -27 Ovarian Cancer 27

TORSION of the PEDICLE Clinical Features Subacute The patient complains of recurrent abdominal pain which passes off as the pedicle untwists. There is a rise in pulse and temperature during the bleeding; and over a period anemia develops. 2003 -10 -27 Ovarian Cancer 28

TORSION of the PEDICLE Clinical Features Acute The signs and symptoms are those of an acute abdominal condition. The problem becomes one of differential diagnosis to exclude those conditions in which laparotomy is not needed and laparoscopy may be useful. Pain tends to be intense and continuous. 2003 -10 -27 Ovarian Cancer 29

TORSION of the PEDICLE Clinical Features Differential Diagnosis ‘Surgical Conditions’ (i. e. those conditions commonly seen and dealt with by a general surgeon. ) Acute appendicitis Meckel’s diverticulitis Obstruction of bowel Diverticulitis 2003 -10 -27 Ovarian Cancer 30

TORSION of the PEDICLE Ruptured Cyst This may occur alone or in conjunction with torsion. Rupture is not particularly upsetting to the patient unless the contents are irritant. 2003 -10 -27 Ovarian Cancer 31

TORSION of the PEDICLE 2003 -10 -27 Ovarian Cancer 32

TORSION of the PEDICLE 2003 -10 -27 Ovarian Cancer 33

RUPTURE OF OVARIAN CYST 2003 -10 -27 Ovarian Cancer 34

RUPTURE OF OVARIAN CYST 2003 -10 -27 Ovarian Cancer 35

RUPTURE OF OVARIAN CYST PSEUDOMYXOMA PERITONEI This rare condition occasionally but not inevitably follows mthe rupture of a mucinous cystadenoma. The epithelial cells implant on the peritoneum and continue to secrete a gelatinous pseudomucin which is not absorbed, or secretion is faster than absorption. The abdominal cavity is eventually filled with the jelly, while the secreting cells spread over the parietal and visceral peritoneum. 2003 -10 -27 Ovarian Cancer 36

RUPTURE OF OVARIAN CYST HYDROTHORAX Hydrothorax may accompany ascites due to any cause, or may occur as an accompaniment of a lung tumor. The so-called Meigs’ syndrome describes the specific condition of ascites and hydrothorax in conjunction with benign ovarian fibroma. 2003 -10 -27 Ovarian Cancer 37

Features suggestive of malignancy 1. Age. If the patient is over 50 the chance of malignancy is over 50% as opposed to less than 15% in premenopausal women. Tumors in childhood are usually malignant. 2. Rapid growth. 3. Ascites. 2003 -10 -27 Ovarian Cancer 38

Features suggestive of malignancy 4. Solid tumours, especially when bilateral. 5. Multilocular cysts with solid areas. (At least 10% of cysts are malignant). 6. Pain. Pressure pain can occur with any tumor; but referred pain suggests malignant involvement of nerve roots. 7. Tumor markers, such as CA 125, may be measured in the blood, but a normal level does not exclude malignancy. 2003 -10 -27 Ovarian Cancer 39

OVARIAN TUMOURS Histological Classification Most tumors arise from the ovarian stroma and germinal epithelium. The embryonic coelom from which that epithelium develops also gives rise to the Mullerian duct from which develop the structures of the genital tract, and it is this common origin which explains the great variety of epithelial patterns which are met with. 2003 -10 -27 Ovarian Cancer 40

OVARIAN TUMOURS PRIMARY EPITHELIAL TUMOR 1. Mucinous cystadenoma or cystadencarcinoma (of. Cervical epithelium). 2. Serous cystadenoma or cystadenocarcinoma (of. tubal epithelium). 3. Endometrioma or Endometrioid carcinoma (of. Endometrium). 4. Clear cell carcinoma. 5. Brenner tumour. 2003 -10 -27 Ovarian Cancer 41

OVARIAN TUMOURS STROMATOUS TUMOURS GERM CELL TUMOURS – – – – . Fibroma or sarcoma. . Dysgerminoma. . Teratoma. . Gonadoblastoma. . Yolk sac tumour. . Carcinoid. Thyroid tumour Choriocarcinoma 2003 -10 -27 Ovarian Cancer 42

OVARIAN TUMOURS HORMONE-PRODUCING TUMORS Estrogen-producing: Granulosa cell tumour. – Thecoma. – Androgen-prodicing: Sertoli-Leydig cell tumour (Arrhenoblastoma). – Hilar cell tumour. – Lipoid cell tumour. – 2003 -10 -27 Ovarian Cancer 43

OVARIAN TUMOURS krukenberg tumour There is one well-known secondary tumour of the ovary, the krukenberg tumour, a secondary of a stomach carcinoma. 2003 -10 -27 Ovarian Cancer 44

OVARIAN TUMOURS --MUCINOUS CYSTADENOMA Definition A unilocular or multilocular cyst of ovary lined by tall columnar epithelium resembling that of the cervix or large intestine. It is usually large and may reach immense proportions, occupying the whole peritoneal cavity and compressing other organs. It may occur at any age. 2003 -10 -27 Ovarian Cancer 45

OVARIAN TUMOURS --MUCINOUS CYSTADENOMA 2003 -10 -27 Ovarian Cancer 46

OVARIAN TUMOURS --MUCINOUS CYSTADENOMA signs and symptoms The signs and symptoms are those generally associated with any nonfunctioning ovarian tumor. Rupture may occur and seeding of the epithelium on the peritoneal surface may cause pseudomyxoma peritonei. 2003 -10 -27 Ovarian Cancer 47

OVARIAN TUMORS --MUCINOUS CYSTADENOCARCINOMA Definition This is only a third as common as the serous variety. Malignancy in a mucinous cyst is characterised by the formation of areas of solid carcinoma in the wall. The cells are columnar, show mitoses and tend to form glandular structures. 2003 -10 -27 Ovarian Cancer 48

OVARIAN TUMORS --SEROUS CYSTADENOMA Definition A unilocular or multilocular cyst lined by epithelium similar to the fallopian tube. They are the most common benign epithelial tumors and form 20% of all ovarian neoplasm. In 10% of cases they are bilateral. It is uncommon to find them large than a fetal head. 2003 -10 -27 Ovarian Cancer 49

OVARIAN TUMORS --SEROUS CYSTADENOMA 2003 -10 -27 Ovarian Cancer 50

OVARIAN TUMORS --SEROUS CYSTADENOCARCINOMA Definition This is by far the commonest primary carcinoma, accounting for 60% of all cases, and in over half the cases it is bilateral. The cysts are always of papillary type and the epithelium burrowing through the capsule produces papillary processes on the serous surface. Extension of the growth to the pelvis and adjacent organs fixes the tumor. Ascites is always present. 2003 -10 -27 Ovarian Cancer 51

CARCINOMA OF THE OVARY Endometrioid Carcinoma of the Ovary It is now recognized that carcinoma of the ovary may be of endometrial type, sometimes arising in endometrioma. Attacks of pain, unusual with ovarian cancer, are common. Sometimes there is uterine bleeding in post-menopausal cases. 2003 -10 -27 Ovarian Cancer 52

CARCINOMA OF THE OVARY Endometrioid Carcinoma of the Ovary Usually the lesion is cystic and chocolate brown in color. If such a cyst ruptures spontaneously, malignancy should be suspected. The histology varies as in uterine carcinoma. It may be a welldifferentiated adenocarcinoma, an adenoacanthoma, mucinous adenocarcinoma or clear-celled carcinoma. 2003 -10 -27 Ovarian Cancer 53

CARCINOMA OF THE OVARY Clear Cell Carcinoma It is doubtful if this exists as a distinct entity. Clear cells may be seen in almost any variety of ovarian carcinoma, but occasionally a carcinoma, usually solid, consists almost entirely of polygonal cells with clear cytoplasm. It behaves in the same way as any other solid carcinoma and has the same prognosis. 2003 -10 -27 Ovarian Cancer 54

CARCINOMA OF THE OVARY Secondary Carcinoma of the Ovary The ovary may be the site of secondary deposits from growths arising in other parts of the genital tract. These are usually overshadowed by the clinical manifestations of the primary growth. 2003 -10 -27 Ovarian Cancer 55

CARCINOMA OF THE OVARY Secondary Carcinoma of the Ovary Ovarian metastases from extragenital tumors are not uncommon. The commonest sites of primary growth are breast, stomach and large intestine. 2003 -10 -27 Ovarian Cancer 56

CARCINOMA OF THE OVARY FIBROMA This is composed of fibrous tissue and resembles fibromata found elsewhere. It is most common in the elderly and accounts for 4 -5% of all ovarian neoplasm. The fibroma is believed by many to be a thecoma which has undergone fibrous transformation. It is sometimes associated with Meig’s syndrome. 2003 -10 -27 Ovarian Cancer 57

CARCINOMA OF THE OVARY GERM CELL TUMOURS There are four main types of gern cell tumour: . Dysgerminoma; –. Tumours of tissues found in the embryo or adult ---- the teratomata; –. Tumours of dysgenetic gonads ---- commonly a gonadoblastoma; –. Tumours of extra-embryonic tissues such as choriocarcinoma or yolk sac tumour. – 2003 -10 -27 Ovarian Cancer 58

CARCINOMA OF THE OVARY Dysgerminoma This is the only solid ovarian tumor of characteristic appearance. Usually ovoid with a smooth capsule, it is of rubbery consistency and greyish colour. It is commonest in younger age groups, under 30 years as a rule, and is often bilateral. Sometimes it is found in cases of intersex. 2003 -10 -27 Ovarian Cancer 59

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CARCINOMA OF THE OVARY Yolk sac tumor This is a rare tumor found in children and young adults. It has a variable histological structure and is highly malignant. The main interest lies in the fact that it produces alphafetoprotein and the blood levels can be used as a diagnostic test and as a means of monitoring response to treatment. 2003 -10 -27 Ovarian Cancer 62

CARCINOMA OF THE OVARY 2003 -10 -27 Ovarian Cancer 63

CARCINOMA OF THE OVARY Estrogen-producing Tumors These belong to the granulosatheca cell group and are found at all ages. They account for 3% of all solid tumors of the ovary. 2003 -10 -27 Ovarian Cancer 64

CARCINOMA OF THE OVARY Estrogen-producing Tumors In childhood there is accelerated skeletal growth and appearance of sex hair. 5% occur in children precocious puberty. 60% occur in child-bearing years irregular menstruation. 30% occur in post-menopausal women post -menopausal bleeding. 2003 -10 -27 Ovarian Cancer 65

CARCINOMA OF THE OVARY ANDOROGEN-PRODUCING TUMOURS Three distinct types of masculinising ovarian tumor are recognised: a) Sertoli. Leydig cell tumor (Arrhenoblastoma), b) Hilar cell tumor, c) Lipoid cell tumor. All three cause amenorrhoea. 2003 -10 -27 Ovarian Cancer 66

Spread of Ovarian Cancer Direct The first spread is directly into neighbouring structures – peritoneum, uterus, bladder, bowel and omentum. 2003 -10 -27 Ovarian Cancer 67

Spread of Ovarian Cancer Lymphatics Ovarian drainage is to the para-aortic glands, but sometimes to the pelvic and even inguinal groups. Cells seeded on to the peritoneum are drained via the lymphatic channels on the underside of the diaphragm into the subpleural glands and thence to the pleura. 2003 -10 -27 Ovarian Cancer 68

Spread of Ovarian Cancer Blood stream Blood spread is usually late, to the liver and lungs. 2003 -10 -27 Ovarian Cancer 69

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SURGICAL PROCEDURES IN OVARIAN CANCER General Principle 1. To classify the growth according to its extent of spread (staging) as accurately as possible. 2. To remove as much cancerous tissue as possible (‘surgical debulking’; ’cytoreductive treatment’). 2003 -10 -27 Ovarian Cancer 72

SURGICAL TREATMENT OF OVARIAN TUMMOURS General Rule Benign ovarian over 10 cm in diameter must be removed, but clinical and ultrasonically diagnosed cysts under 10 cm (the size of a lemon) in women under 35 years may be reviewed in a few months if there is no suspicion of malignancy. A follicular or luteral cyst may resolve spontaneously. 2003 -10 -27 Ovarian Cancer 73

SURGICAL TREATMENT OF OVARIAN TUMMOURS 2003 -10 -27 Ovarian Cancer 74

SURGICAL TREATMENT OF OVARIAN TUMMOURS 2003 -10 -27 Ovarian Cancer 75

SURGICAL TREATMENT OF OVARIAN TUMMOURS 2003 -10 -27 Ovarian Cancer 76

TREATMENT OF OVARIAN CANCER General Principle Much attention is being directed towards the treatment of epithelial ovarian cancer which is now the most frequent cause of death from gynecological malignancy. The principles of treatment are: 2003 -10 -27 Ovarian Cancer 77

TREATMENT OF OVARIAN CANCER General Principle Ovarian carcinoma is staged surgically, so laparotomy is an essential part of management for most patients. Surgical removal of as much malignant tissue as possible, even if this should call for resection of structures outside the normal field of the gynecologist. 2003 -10 -27 Ovarian Cancer 78

TREATMENT OF OVARIAN CANCER General Principle Follow-up with intensive chemotherapy, using various combinations of antineoplastic drugs. Taxanes, probably combined with platinum compounds, are an appropriate first choice. A ‘second look’ laparotomy or laparoscopy operation (SLO), to determine the actual effectiveness of the chemotherapy and to decide whether it should be stopped does not affect prognosis, so should only be performed with informed consent in clinical trials. 2003 -10 -27 Ovarian Cancer 79

SURGICAL PROCEDURES IN OVARIAN CANCER Incision A vertical incision which can be extended is essential to allow a full inspection. Reduction of a cyst by tapping and extraction through a suprapubic incision is not acceptable practice. 2003 -10 -27 Ovarian Cancer 80

SURGICAL PROCEDURES IN OVARIAN CANCER Cytology Before handling the tumour, take specimens of ascitic fluid or peritoneal saline washings for cytological examination, and a cytology smear from the underside of the diaphragm. 2003 -10 -27 Ovarian Cancer 81

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