Incest and folkdancing Steve jones Steve Jones 2001

Incest and folk-dancing ….

Steve jones Steve Jones 2001 Pan Pacific Bodybuilding Champion

Elephant seal

Testosterone Molecule

M-f mortality

Female anglerfish and her partners

The Y

Male

Thames at Westminster

Thames near Source

Drosophila bifurca – testis, the single sperm, and a standard of comparison

The Apocalypse according to William Blake

The city of Megiddo – the biblical Armageddon

THE ARITHMETIC OF ARMAGEDDON – 722 BC 2, 4, 8, 16, 32 …… fifty times: comes to 100, 000, (a hundred million) supposed ancestors. At a generous guess the real number of people then was 100, 000 (a hundred million). Ie not enough ancestors - which means SHARED ANCESTRY AND UNIVERSAL INBREEDING!

Present 22 individuals 18 ancestors Time

Present 22 individuals 18 ancestors 16 ancestors Time

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors Time

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors Time

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors Time

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors 3 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors 3 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors 3 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors 3 ancestors 2 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors 3 ancestors 2 ancestors

Present 22 individuals 18 ancestors 16 ancestors 14 ancestors 12 ancestors 9 ancestors 8 ancestors Time 8 ancestors 7 ancestors 5 ancestors 3 ancestors 2 ancestors 1 ancestor

Present Time

Present Time Most recent common ancestor (MRCA)

Inbreedign euro royalty Serious inbreeding among European Royals (max at 7 generations = 128 ancestors) Generations 4 5 6 7 Ift de Espana (1901 -1964) 8 12 12 12 Gottfried of Tuscany (1901 -) 8 10 15 18 Alfonso XII King of Spain (1857 -1885) 4 4 6 8 Francesco, Duke of Marchena (1861 -1923) 2 4 8 8 Maria Antonia of Austria (1669 -1692) 4 4 6 10 Louis XV King of France (1710 -1774) 4 8 12 16

Tutankhamun’s pedigree - incest

Feet of an inbred God - Tutankhamun

3000 lines of descent 4000 lines of descent Inbred – identity by descent

Charles Darwin’s cousin marriage

The Bulldog in 1817

The Bulldog in 2008

Rare surnames (Attenborough but not Smith) share a Y chromosome

Consang marriage rates ww

Finnish genetic disease

VLINCL pedigrees in Finland

Inbreeding loops in Finland

Likely world colonisation routes, and genetic distance from E Africa (shades of green)

Extent of diversity against distance to Addis Ababa – lowest in Americas

Runs of homozygosity – shared names, and shared lengths of DNA attenborough agccccttaatta

Inbreeding in Croatia

Runs of homozygosity of different lengths, island mainland

Close correlation between inbreeding as measured from pedigrees and from runs of homozygosity

Runs of homozygosity: more inbreeding in hunter-gatherers than farmers

Runs of homozygosity (green blocks) in boy with multiple medical problems. May be son of incestuous relationship

The locations of the identified IBD segments (black horizontal bars) among the genomes of the colon cancer patients and the control data sets.

Runs of homozygosity and schizophrenia: odds increase by 17% for every 1% increase in genome-wide autozygosity.

ROH in Early Onset Parkinson’s Disease; cases blue controls red. Black line – ratio.

Increase in infection rates with inbreeding

Sex and the 747 – American flight patterns

Decline in US runs of homozygosity (inbreeding) with birth date from 1900 to 2000

Jones in 1881

Jones in 1998

Fig. 1 Language locations and regional variation in phonemic diversity – bottlenecks on the way across the world. Q D Atkinson Science 2011; 332: 346 -349 Published by AAAS

Outbred and inbred slug populations Oxfordshire (left); Skye (right)