Nanomanufacturing Med Tech Research at UMass Lowell Mass

Nanomanufacturing & Med. Tech Research at UMass Lowell Mass. MEDIC April 10, 2007

Nanomanufacturing Programs at UMass Lowell • NSF NSEC Center for High-Rate Nanomanufacturing. 9/04: $12. 4 MM UMass Lowell , Northeastern and UNH • Nanomanufacturing Center of Excellence 12/04: John Adams Innovation Institute $5 MM to UMass Lowell. • New Nano/Bio/Manufacturing Building 4/07 Gov. Patrick commits $25 MM Cash + $16 MM Bond for

Commercialization of Nanotechnology: Nanomanufacturing is a Vital Component New Fabrics Flexible Electronics, Sensors, Implants Nano Capsule for Drug Delivery Biosensors (radiation, cancer, anthrax, insulin. . . ) Nano Manufacturing Research Drugs by Design New Reinforced Materials

The Path to Commercialization Nanoscience Scientific discovery, basic theory, test hypotheses Nanomanufacturing Science Process science (models, discovery of process methods, reliability theory, enabling tools) Fundamental science focused on manufacturing NSF NSEC Center for High Rate Nanomanufacturing • • Materials suppliers Process equipment manufacturers On-line measurement equipment Products (bio, electronic, automotive, chemical, aerospace…) Product Prototypes, Scalable processes Specific product process development, “prototype” products Nanomanufacturing Center of Excellence Process Scale up Short production runs, debug scale up Production

Nanomanufacturing at CHN Manipulation of billions of atoms and nanoparticles Biosensors Templates High rate High volume Reliability Memory devices Informed public and workforce Environmentally benign processes CH N

CHN Vision: Guided Self Assembly Nanomanufacturing Through High-rate/High-volume Templates for Guided Self-Assembly of Nanoelements Will provide the tools to manufacture a wide range of nanoscale products

Nanopatterned Surfaces Nanotemplates as tooling surface in high rate process microinjection molding machine Injection Molder Biosensors (radiation, cancer, anthrax, etc. ) + Ig. G

NCOE Vision: Capitalize on Polymer Advantages • Lightweight • Flexible • Biologically compatible • Easily adapted for high rate processes

Electrospun Nanofibers Dr. Mead, Plastics Engineering Inner core Selectively permeable materials • provide mechanical or • highly breathable electrical properties • impermeable to liquid water Outer core • stretchable • highly absorbent material • novel textiles • tissue scaffolding

Controlled Patterning of Nano. Fibers Dr. Chen, Mechanical Engineering Electrospinning can be used to create submicron diameter fibers with high surface area and fabrics with fine porosity Greater functionality (and information content) can be achieved through controlled patterns, rather than random mats

Layered Materials on Nanofibers Dr. Kumar, Physics Department H-PURET PAH CA Fiber 1 bilayer 5 bilayers Coated Materials include • Polyelectrolytes • Metal Oxides • Conjugated Polymers 10 bilayers Applications include • Photovoltaic Cells • Sensors • Catalysts • Water purification Continuous Ti. O 2 on Polyacrylonitrile Ti. O 2 particles on Functionalized Polyacrylonitrile

Nanomultilayer Coextrusion Drs. Barry & Mead, Plastics Engineering • Utilize coextrusion process – Two polymers of dissimilar structure and properties to be combined – Nanolayer laminates with hundreds or thousands of layers – No nanoscale dimensions on tooling – Conventional coextrusion facilities can be used except layer-multiplying elements 2 nd 1 st 3 rd 2 nd 4 th

Nanocomposites Drs. Barry , Mc. Carthy & Mead, Plastics Engineering Nanocomposites • High performance properties • Issue is repeatable dispersion in commercially viable process • Study effect of process conditions/material on dispersion • Nanoclay • Nanoparticulates (alumina, silica, carbon black) Improved • Barrier properties • Mechanical properties • Flame retardance • Thermal properties

Surface Functionalization and Characterization Dr. Whitten; Chemistry Self-assembled monolayers (SAMs), including alkanethiols adsorbed on gold surfaces • Thiophene-terminated alkanethiols have been sythesized and used to coat gold nanoparticles. • Organic vapor sensors have been fabricated from the monolayer protected gold nanoparticle films. *H. Ahn, A. Chandekar, C. Sung and J. E. Whitten, Chemistry of Materials, vol. 16, p. 3274 (2004).

Nanospherical Gold Delivery Systems Dr. Braunhut, Biology • Targeted/controlled delivery In conjunction with Triton Biosystems of Chelmsford, MA “Non-invasive product that kills cancer using localized lethal heat with negligible damage to healthy tissues”

Biodegradable Hollow Nanospheres for Self-assembly of Polymer Micelles Drug Delivery Stephen P. Mc. Carthy, Plastics Engineering, 978. 934. 3417 Self-assembly in water Optional removal of core • Core-shell structure • Shell can be crosslinked • Core can be selectively removed • Shell and/or core can be functionalized selectively

Biodegradable Hollow Nanospheres for Drug Delivery Stephen P. Mc. Carthy, Plastics Engineering, 978. 934. 3417 Atomic Force Microscopy Analysis of Nanoparticles Self-assembly in water Optional removal of core Self Assembly of Polymer Micelles Well-defined spherical nanoparticles observed • Core-shell structure • Shell can be crosslinked • Core can be selectively removed • Shell and/or core can be functionalized selectively Rh H mica R mica Transdermal Delivery of Insulin with Cationic Shell-xlinked Hollow Nanospheres in Hyperglycemic Rats Glucose tolerance test in normal rats Typical curve with expected value of cac

Biodegradable Hollow Nanospheres for Highlights of Results Drug Delivery Stephen P. Mc. Carthy, Plastics Engineering, 978. 934. 3417 Oral and transdermal delivery of insulin Encapsulation of hydrophobic and hydrophilic substances Transdermal delivery of antiinflammatory agents Encapsulation of nutrients, such as Vitamin E Antibacterial properties of cationic nanospheres

Massachusetts Medical Device Development Center (M 2 D 2) UMASS Lowell & UMass Worcester

M 2 D 2 Mission Connect the resources of the University of Massachusetts to Medical Device firms within Massachusetts Network Education M 2 D 2 Product Realization Process Business Realization Process

Medical Device Industry Critical to. What. Massachusetts’ Future was Once An Economic Engine Is Now Declining Compared to Others Source: Economy. com 4 digit NAICS code 3391 Employment: Medical Equipment & Supplies Manufacturing

With M 2 D 2 They Can Reach Across M 2 D 2 Investors Inventors Markets Products Ideas Mock-Ups Proof of Concept Business Plan Team

Product/Business Realization Process Creates 8 -11 Companies/Year 17 -24 months Screening Seed Fund Prototype (2 -4 mos) (3 -8 mos) & Animal Trials 15% 50% Unqualified Leads 300/yr Human Trials (18 -24 mos) (12 mos) 50% 75% 300 45 22 11 8 -11 Markets & Investors FDA Regulatory Submission Prototype demonstrated in Animals/Cadavers Seed funding obtained & Business Plan Competitive Selection Milestone

M 2 D 2 Helps Entrepreneurs Find Funds Seed Funding process requires 3 -8 months Depending on concept quality & funding source • • SBIR grants STTR grants John Adams Innovation Institute Angel investors

Multiple Companies Already Benefiting • Perfusion Technology UMass Lowell Incubator ( SBIR, April 2006, August 2006) Ultrasound Enabled Drug Delivery To the Brain

Multiple Companies Already Benefiting • Spire Biomedical Bedford, MA (SBIR, December 2006) Novel Dialysis Catheter

Multiple Companies Already Benefiting • Vista Scientific Andover, MA (STTR, April 2007) Nanosphere-Antibiotic Corneal Contact Lens Delivery System

Multiple Companies Already Benefiting • Vaso. Tech Worcester, MA (Fast. Track, April 2007) Biodegradable Drug Eluting Stent

Multiple Companies Already Benefiting • Boste. Q Boston, MA (STTR April 2007) Vibrotactile Tilt Feedback for Balance Rehabilitation and Elderly Fall Reduction

M 2 D 2 Steering Committee • • • • Hooks Johnston, Chair (SVP, Smith & Nephew, Retired) Daniel Baril, President & CEO, Baril Die Company John Brooks III, General Partner, Prism Venture Partners Thomas Chmura, Vice President for Economic Development, University of Massachusetts President’s Office Paul Fenton, President, Axya Medical Robert Halpin, President & CEO, MVEDC, Inc. John Konsin, Executive Vice President & General Manager, Accellent Endoscopy Peter Litman, Vice President for Business Development and Marketing, Anika Therapeutics, Inc. Stephen Mc. Carthy, Co-Director, M 2 D 2, University of Massachusetts Lowell Sheila Noone, Co-Director, M 2 D 2, University of Massachusetts Worcester Richard Packer, President & CEO, Zoll Medical Corporation Thomas Sommer, President, Mass. MEDIC Josh Tolkoff, Managing Director, Ironwood Equity Fund LP Edward C. Williams III, Partner, Brook Venture Partners

Big Things from Small Science • Continuing the tradition of manufacturing excellence in Lowell region – Education – Research – Service to industry and the community • Sustainable economic development for the US