Muscular System Muscle Tissues n Skeletal Muscle n
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Muscular System
Muscle Tissues n Skeletal Muscle n Smooth Muscle n Cardiac Muscle
Skeletal Muscle n n n Usually attached to bones Under conscious control Striated
Smooth Muscle n n n Walls of most viscera, blood vessels, and skin Not under conscious control Not striated
Cardiac Muscle n n n Wall of heart Not under conscious control Striated
Structure of a Skeletal Muscle n n n n Organ of the muscular system Skeletal muscle tissue Nervous tissue Blood Connective tissues Fascia Tendon aponeuroses
Structure of a Skeletal Muscle
Structure of a Skeletal Muscle n n n n n Epimysium Perimysium Fascicle Endomysium Muscle Fascicles Muscle fibers Myofibrils Thick and thin filaments
Skeletal Muscle Fiber n n n Sarcolemma Sacroplasm Sarcoplasmic reticulum Transverse tubule Traid ¡ ¡ n n Cisterna of sarcoplasmic reticulum Transverse tubule Myofibril Actin filaments Myosin filaments sarcomere
Sarcomere n n n I band A band H zone Z line M line
Myofilaments n Thick filaments ¡ ¡ n Composed of myosin Cross-bridges Thin filaments ¡ ¡ Composed of actin Associated with troponin and tropomyosin
Neuromuscular Junction n n n Site where axon and muscle fiber communicate Motor neuron Motor end plate Synaptic cleft Synaptic vesicles Neurotransmitters
Motor Unit n n Single motor neuron All muscle fibers controlled by motor neuron
Stimulus for Contraction n n Acetylcholine (ACh) Nerve impulse causes release of ACh from synaptic vesicles Binds to ACh receptors on motor end plate Generates a muscle impulse Muscle impulse eventually reaches sarcoplasmic reticulum
Excitation Contraction Coupling n n n Muscle impulses cause sarcoplasmic retuculum to release calcium ions into cytosol Calcium binds to troponin to change its shape Position of tropomyosin is altered Binding sites on actin exposed Actin and myosin bind
Sliding Filament Theory n n n When sarcromeres shorten, thick and thin filaments slide past one another H zones and I bands get narrower Z lines move closer together
Cross-Bridge Cycling n n n n Actin and myosin cross-bridge bind Myosin cross-bridge pulls actin ADP and phosphate released from myosin New ATP binds to myosin Linkage between actin and myosin crossbridge break ATP splits Myosin cross-bridge goes back to original position
Relaxation n n Acetylcholinesterase- breaks down Ach Muscle impulse stops Calcium moves back into sarcoplasmic reticulum Myosin and actin binding prevented
Energy Sources for Contraction n 1)Creatine phosphate ¡ n Creatine phosphate stores energy that quickly converts ADP to ATP 2) Cellular respiration
Oxygen Supply & Cellular Respiration n Anaerobic Phase ¡ ¡ n Glycolysis Produces little ATP Aerobic Phase ¡ ¡ Citric acid cycle Electron transport chain Produces most ATP Myoglobin stores extra oxygen
Oxygen Debt n Oxygen debt- amount of oxygen needed by liver to convert lactic acid to glucose n n Oxygen not available Glycolysis continues Pyruvic acid converted to lactic acid Liver converts lactic acid to glucose
Muscle Fatigue n n Inability to contract Commonly caused from ¡ ¡ ¡ n Decreased blood flow Ion imbalances Accumulation of lactic acid Cramp- sustained, involuntary contraction
Heat Production n By product of cellular respiration Muscle cells are major source of body heat Blood transport heat throughout body
Muscular Responses n Threshold Stimulus- minimal strength required to cause contraction n Recording a muscle contraction ¡ Twitch ¡ Latent period ¡ Period of contraction ¡ Period of relaxation ¡ Refractory period ¡ All-or-none response
Summation n (a) Process by which individual twitches combine n (b) Produces sustained contractions n (c) Can lead to tetanic contractions
Recruitment of Motor Units n n n Recruitment- increase in the number of motor units activated Whole muscle composed of many motor units As intensity of stimulation increases, recruitment of motor units continues until all motor units are activated
Sustained Contractions n n Smaller motor units recruited first Larger motor units recruited later Produces smooth movements Muscle tone- continuous state of partial contraction
Types of Contractions n n Isotonic- muscle contracts and changes length Concentric- shortening contraction Eccentric- lengthening contraction Isometric- muscle contracts but does not change length
Fast & Slow Twitch Muscle Fibers n Slow-Twitch fibers (type I) ¡ ¡ ¡ Always oxidative Resistant to fatigue Red fibers Most myoglobin Good blood supply n Fast-Twitch glycolytic fibers (type IIa) ¡ ¡ ¡ n White fibers (less myoglobin) Poorer blood supply Susceptible to fatigue Fast-Twitch fatigue-resistant fibers (type IIb) ¡ ¡ Intermediate fibers Oxidative Intermediate amount of myoglobin Pink to red in color
Smooth Muscle Fibers n Compared to skeletal muscle fibers ¡ ¡ ¡ ¡ Shorter Single nucleus Elongated with tapering ends Myofilaments randomly organized No striations Lack transverse tubules Sarcoplasmic reticula not well developed
Types of Smooth Muscle n Visceral Smooth Muscle ¡ ¡ ¡ n Single-unit smooth muscle Sheets of muscle fibers Fibers held together by gap junctions Exhibit rhythmicity Exhibit peristalsis Walls of most hollow organs Multiunit Smooth Muscle ¡ ¡ ¡ Fibers function separately Irises of eye Walls of blood vessels
Smooth Muscle Contraction n Resembles skeletal muscle contraction ¡ ¡ ¡ n Interaction between actin and myosin Both use calcium and APT Both depend on impulses Different from skeletal muscle contraction ¡ ¡ ¡ Smooth muscle lacks troponin Smooth muscle depents on calmodulin Two neurotransmitters affect smooth muscle n ¡ ¡ Acetlycholine and norepinephrine Hormones affect smooth muscle Stretching can trigger smooth muscle contraction Smooth muscle slower to contract and relax Smooth muscle more resistant to fatigue
Cardiac Muscle n n n Only in the heart Muscle fibers joined together by intercalated discs Fibers branch Network of fibers contracts as a unit Self-exciting and rhythmic Longer refractory period than skeletal muscle
Skeletal Muscle Actions n n n Origin- immovable end Insertion- movable end Prime mover (agonist) – primarily responsible for movement (deltoid) Synergists – assist prime mover Antagonist – resist prime mover’s action and cause movement in the opposite direction
Major Skeletal Muscles
Major Skeletal Muscles
Muscles of Facial Expression
Muscles of Mastication
Muscles of Facial Expression & Mastication
Muscles that Move: Head & Vertebral Column
Muscles that Move: Pectoral Girdle
Muscles that Move the Arm
Deep Muscles of the Back & Neck
Muscles of the Shoulder & Back
Muscles of: Anterior Chest & Abdominal Wall
Muscles that Move the Forearm
Muscles that Move the Head
Muscles of the Shoulder & Arm
Cross Section of the Arm
Muscles of the Shoulder & Arm
Muscles of the Arm & Forearm
Muscles of the Arm & Forearm
Cross Section of the Forearm
Muscles of the Abdominal Wall
Muscles of the Abdominal Wall
Muscles of the Pelvic Outlet
Muscles of Pelvic Outlets & Urogenital Diaphragm
Muscles that Move the Thigh
Muscles that Move the Leg
Muscles that Move the Foot
Muscles of the Thigh & Leg
Muscles of the Thigh & Leg
Muscles of the Thigh & Leg
Cross Section of the Thigh
Muscles of the Leg
Muscles of the Leg
Muscles of the Leg
Cross Section of the Leg
Life-Span Changes n n Myoglobin, ATP, and creatine phosphate decline By age 80, half of muscle mass has atrophied Adipose cells and connective tissues replace muscle tissue Exercise helps to maintain muscle mass and function
Clinical Application n Myasthenia Gravis ¡ ¡ ¡ Autoimmune disorder Receptors for acetylcholine on muscle cells are attacked Weak and easily fatigued muscles result Difficulty swallowing and chewing Ventilator needed if respiratory muscles are affected Treatments include: n n Drugs that boost acetylcholine Removing thymus gland Immunosuppressant drugs antibodies
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