Respiratory System 1 Respiration Ventilation Movement of air

Respiratory System 1

Respiration • Ventilation: Movement of air into and out of lungs • External respiration: Gas exchange between air in lungs and blood • Transport of oxygen and carbon dioxide in the blood • Internal respiration: Gas exchange between the blood and tissues • Cellular Respiration: The use of O 2 to produce ATP via Glycolysis, TCA cycle, & ETS 2

Respiratory System Functions • Gas exchange: Oxygen enters blood and carbon dioxide leaves • Regulation of blood p. H: Altered by changing blood carbon dioxide levels Carbonic acid Buffer system • Sound production: Movement of air past vocal folds makes sound and speech • Olfaction: Smell occurs when airborne molecules drawn into nasal cavity • Thermoregulation: Heating and cooling of body • Protection: Against microorganisms by preventing entry and removing them 3

Respiratory System Divisions • Upper tract – Nose, pharynx and associated structures • Lower tract – Larynx, trachea, bronchi, lungs 4

Nasal Cavity and Pharynx 5

Nose and Pharynx • Nose – External nose – Nasal cavity • Functions – – – Passageway for air Cleans the air Humidifies, warms air Smell Along with paranasal sinuses are resonating chambers for speech • Pharynx – Common opening for digestive and respiratory systems – Three regions • Nasopharynx • Oropharynx • Laryngopharynx 6

Larynx • Functions – Maintain an open passageway for air movement – Epiglottis and vestibular folds prevent swallowed material from moving into larynx – Vocal folds are primary source of sound production 7

Vocal Folds 8

Trachea Insert Fig 23. 5 all but b • Windpipe • Divides to form – Primary bronchi – Carina: Cough reflex 9

Tracheobronchial Tree • Non-Acinus -Conducting zone – Trachea to terminal bronchioles which is ciliated for removal of debris, mucus lined – Passageway for air movement controlled by smooth muscle at end of terminal bronchioles – Cartilage holds tube system open and smooth muscle controls tube diameter • Acinus Portion - Respiratory zone – Respiratory bronchioles to alveoli – Site for gas exchange Area the size of a football field 10

Tracheobronchial Tree 11

Bronchioles and Alveoli 12

Alveolus and Respiratory Membrane 13

Lungs • Two lungs: Principal organs of respiration – Right lung: Three lobes – Left lung: Two lobes • Divisions – Lobes, bronchopulmonary segments, lobules 14

Thoracic Walls Muscles of Respiration 15

Thoracic Volume 16

Pleura • Pleural fluid produced by pleural membranes – Acts as lubricant – Helps hold parietal and visceral pleural membranes together 17

Ventilation • Movement of air into and out of lungs via negative pressure pump mechanism • Air moves from area of higher pressure outside the lung to area of lower pressure created in the thorax and lungs by diaphram • Pressure is inversely related to volume in that as pressure goes down lung volume goes up 18

Alveolar Pressure Changes 19

Changing Alveolar Volume • Lung recoil – Causes alveoli to collapse resulting from • Elastic recoil and surface tension : Pneumothorax – Surfactant: Reduces tendency of lungs to collapse • Pleural pressure – Negative pressure can cause alveoli to expand – Pneumothorax is an opening between pleural cavity and air that causes a loss of pleural pressure 20

Normal Breathing Cycle 21

Compliance • Measure of the ease with which lungs and thorax expand – The greater the compliance, the easier it is for a change in pressure to cause expansion – A lower-than-normal compliance means the lungs and thorax are harder to expand • Conditions that decrease compliance – Pulmonary fibrosis – Pulmonary edema – Respiratory distress syndrome 22

Pulmonary Volumes • Tidal volume – Volume of air inspired or expired during a normal inspiration or expiration • Inspiratory reserve volume – Amount of air inspired forcefully after inspiration of normal tidal volume • Expiratory reserve volume – Amount of air forcefully expired after expiration of normal tidal volume • Residual volume – Volume of air remaining in respiratory passages and lungs after the most forceful expiration 23

Pulmonary Capacities • Inspiratory capacity – Tidal volume plus inspiratory reserve volume • Functional residual capacity – Expiratory reserve volume plus the residual volume • Vital capacity – Sum of inspiratory reserve volume, tidal volume, and expiratory reserve volume • Total lung capacity – Sum of inspiratory and expiratory reserve volumes plus the tidal volume and residual volume 24

Spirometer and Lung Volumes/Capacities 25

Minute and Alveolar Ventilation • Minute ventilation: Total amount of air moved into and out of respiratory system per minute • Respiratory rate or frequency: Number of breaths taken per minute • Anatomic dead space: Part of respiratory system where gas exchange does not take place • Alveolar ventilation: How much air per minute enters the parts of the respiratory system in which gas exchange takes place 26

Physical Principles of Gas Exchange • Partial pressure – The pressure exerted by each type of gas in a mixture – Dalton’s law – Water vapor pressure • Diffusion of gases through liquids – Concentration of a gas in a liquid is determined by its partial pressure and its solubility coefficient – Henry’s law 27

Physical Principles of Gas Exchange • Diffusion of gases through the respiratory membrane – Depends on membrane’s thickness, the diffusion coefficient of gas, surface areas of membrane, partial pressure of gases in alveoli and blood • Relationship between ventilation and pulmonary capillary flow – Increased ventilation or increased pulmonary capillary blood flow increases gas exchange – Physiologic shunt is deoxygenated blood returning from lungs 28

Oxygen and Carbon Dioxide Diffusion Gradients • Oxygen – Moves from alveoli into blood. Blood is almost completely saturated with oxygen when it leaves the capillary – P 02 in blood decreases because of mixing with deoxygenated blood – Oxygen moves from tissue capillaries into the tissues • Carbon dioxide – Moves from tissues into tissue capillaries – Moves from pulmonary capillaries into the alveoli 29

Changes in Partial Pressures 30

Hemoglobin and Oxygen Transport • Oxygen is transported by hemoglobin (98. 5%) and is dissolved in plasma (1. 5%) • Oxygen-hemoglobin dissociation curve shows that hemoglobin is almost completely saturated when P 02 is 80 mm Hg or above. At lower partial pressures, the hemoglobin releases oxygen. • A shift of the curve to the left because of an increase in p. H, a decrease in carbon dioxide, or a decrease in temperature results in an increase in the ability of hemoglobin to hold oxygen 31

Hemoglobin and Oxygen Transport • A shift of the curve to the right because of a decrease in p. H, an increase in carbon dioxide, or an increase in temperature results in a decrease in the ability of hemoglobin to hold oxygen • The substance 2. 3 -bisphoglycerate increases the ability of hemoglobin to release oxygen • Fetal hemoglobin has a higher affinity for oxygen than does maternal 32

Oxygen-Hemoglobin Dissociation Curve at Rest 33

Oxygen-Hemoglobin Dissociation Curve during Exercise 34

Shifting the Curve 35

Transport of Carbon Dioxide • Carbon dioxide is transported as bicarbonate ions (70%) in combination with blood proteins (23%) and in solution with plasma (7%) • Hemoglobin that has released oxygen binds more readily to carbon dioxide than hemoglobin that has oxygen bound to it (Haldane effect) • In tissue capillaries, carbon dioxide combines with water inside RBCs to form carbonic acid which dissociates to form bicarbonate ions and hydrogen ions 36

Transport of Carbon Dioxide • In lung capillaries, bicarbonate ions and hydrogen ions move into RBCs and chloride ions move out. Bicarbonate ions combine with hydrogen ions to form carbonic acid. The carbonic acid is converted to carbon dioxide and water. The carbon dioxide diffuses out of the RBCs. • Increased plasma carbon dioxide lowers blood p. H. The respiratory system regulates blood p. H by regulating plasma carbon dioxide levels 37

Carbon Dioxide Transport and Chloride Movement 38

Respiratory Areas in Brainstem • Medullary respiratory center – Dorsal groups stimulate the diaphragm – Ventral groups stimulate the intercostal and abdominal muscles • Pontine (pneumotaxic) respiratory group – Involved with switching between inspiration and expiration 39

Respiratory Structures in Brainstem 40

Rhythmic Ventilation • Starting inspiration – Medullary respiratory center neurons are continuously active – Center receives stimulation from receptors and simulation from parts of brain concerned with voluntary respiratory movements and emotion – Combined input from all sources causes action potentials to stimulate respiratory muscles • Increasing inspiration – More and more neurons are activated • Stopping inspiration – Neurons stimulating also responsible for stopping inspiration and receive input from pontine group and stretch receptors in lungs. Inhibitory neurons activated and relaxation of respiratory muscles results in expiration. 41

Modification of Ventilation • Chemical control • Cerebral and limbic system – Respiration can be voluntarily controlled and modified by emotions – Carbon dioxide is major regulator • Increase or decrease in p. H can stimulate chemosensitive area, causing a greater rate and depth of respiration – Oxygen levels in blood affect respiration when a 50% or greater decrease from normal levels exists 42

Modifying Respiration 43

Regulation of Blood p. H and Gases 44

Herring-Breuer Reflex • Limits the degree of inspiration and prevents overinflation of the lungs – Infants • Reflex plays a role in regulating basic rhythm of breathing and preventing overinflation of lungs – Adults • Reflex important only when tidal volume large as in exercise 45

Ventilation in Exercise • Ventilation increases abruptly – At onset of exercise – Movement of limbs has strong influence – Learned component • Ventilation increases gradually – After immediate increase, gradual increase occurs (4 -6 minutes) – Anaerobic threshold is highest level of exercise without causing significant change in blood p. H • If exceeded, lactic acid produced by skeletal muscles 46

Effects of Aging • Vital capacity and maximum minute ventilation decrease • Residual volume and dead space increase • Ability to remove mucus from respiratory passageways decreases • Gas exchange across respiratory membrane is reduced 47