Liver Flukes Fasciola hepatica Fasciola gigantica Fascioloides magna
- Slides: 50
Liver Flukes • • • Fasciola hepatica Fasciola gigantica Fascioloides magna Dicrocoelium dendriticum Clonorchis sinensis
Habitat: live in the duct system of the liver!
Between any three liver cells there is a bile capillary (Bile Canaliculus) Flukes feed on epithelial cells, blood, and mucous caused by destruction of these cells!
Fasciola hepatica “The Sheep Liver Fluke” • Because sheep are the normal definitive host. • In places where sheep are not raised can be found in cattle. • Humans can become infected! 30 mm long
Fasciola gigantica • Equivalent of F. hepatica in Southeast Asia, Hawaii, and Africa. • Basically big species of F. hepatica. 75 mm long 30 mm long
Fascioloides magna “Giant Deer Fluke or Giant Liver Fluke” • Found in deer, moose, and elk. • Sometimes in cattle, bison, sheep, goats, llamas, and pigs. • Never found in people! 100 mm long!
Fascioloides magna “Giant Deer Fluke or Giant Liver Fluke” • Domestic ruminants are aberrant hosts. • Common parasite in N. America especially in the Gulf coast, N. W. , and Great Lakes area!
Dicrocoelium dendriticum The Lancet Fluke • Sheep, goats, deer, cattle, rabbits, and woodchucks. • Occasionally found in people. 10 mm long
Dicrocoelium dendriticum The Lancet Fluke • Cosmopolitan distribution but predominantly found in Eastern Europe.
Clonorchis sinensis “Chinese Liver Fluke or Oriental Liver Fluke” • Carnivorous animals are definitive hosts. • Dogs and cats (animals that eat fish-2 nd IH) also occurs in people. • Also found in pigs, rats and camels (? )! 8 -25 mm long
Clonorchis sinensis “Chinese Liver Fluke or Oriental Liver Fluke” • Orient – Korea – Thailand – Vietnam – Japan – China
Life Cycles! • Liver fluke of ruminants and man: Fasiola hepatica, Fasciola gigantica and Fascioloides magna!
Life Cycles of Ruminant Liver Flukes • First intermediate hosts are snails in the family Lymnaeidae (pond snails): these are aquatic and semiaquatic snails.
Liver flukes of ruminants (aquatic life cycle).
Eggs of Fasciola hepatica Eggs are 130 -150 X 63 -90 μm; golden brown, indistinct operculum, and unembryonated.
Miricidia develop in the egg (9 -10 days) in the external environment, hatch and infect snail 1 st IH
In the snail they develop sporocysts, 2 redia generations which release cercariae into the external aquatic environment! (five to seven weeks)
Cercariae encyst as metacercariae on aquatic vegetation! Grass and water cress are typical 2 nd IH
What happens in the DH
What happens in the DH • Juvenile worms penetrate the small intestine: enter the coelom and creep over the viscera until contacting the liver capsule!
What happens in the DH • Juvenile worms penetrate the small intestine: enter the coelom and creep over the viscera until contacting the liver capsule! • They then burrow into the liver parenchyma: wander about for almost two months feeding and growing.
What happens in the DH • Juvenile worms penetrate the small intestine: enter the coelom and creep over the viscera until contacting the liver capsule! • They then burrow into the liver parenchyma: wander about for almost two months feeding and growing. • Finally they enter the bile ducts: worms become sexually mature in another month and begin producing eggs. PPP- 8 -10 wk. Live for 11 years!
Fasciola hepatica “The Sheep Liver Fluke” • Distribution is cosmopolitan, and they are found primarily in agricultural animals. • In US and S. America commonly found in sheep and cattle.
Habitat Found In Flooded Pastures!
Life cycle of Dicrocoelium dendriticum The Lancet Fluke Terrestrial life cycle!
Terrestrial land snails 1 st IH Cercariae accumulate and produce mucus
Ants 2 nd IH Terrestrial land snails 1 st IH Slimeball! (500 cercariae)
“Brainworms” Attachment to subesophageal ganglion Ants 2 nd IH Terrestrial land snails 1 st IH
Up to 50, 000 worms in 1 DH! Ants 2 nd IH Terrestrial land snails 1 st IH
Life cycle of Dicrocoelium dendriticum The Lancet Fluke • Rabbits (also DHs) – Intensity infections in sheep/goats • Deer (also DHs) – Disseminate between populations • Sale/Trade of infected sheep – Establish entirely new populations
Life Cycle of Clonorchis sinensis “Chinese Liver Fluke” • Aquatic life cycle!
Clonorchis sinensis Snails 1 st IH ingest eggs Miracidium Sporocyst Rediae
Clonorchis sinensis Snails 1 st IH ingest eggs Miracidium Sporocyst Rediae Cercariae Encyst under scale or in muscle of freshwater fish 2 nd IH Metacercariae
Clonorchis sinensis Snails 1 st IH ingest eggs Miracidium Sporocyst Rediae Cercariae Encyst under scale or in muscle of freshwater fish 2 nd IH Metacercariae Adult DH Egg production 1 month 3 months total Adults live 8 years
Eggs of Clonorchis sinensis • Vase shaped, 26 -30 X 15 -17 µm long, golden brown with a distinct operculum and abopercular knob.
Commercial Fish Ponds Night soil!
What do liver flukes do to the host? • Seldom kill host; but do interfere with health of the host. • More significant to us because of agriculture. • If animals are infected, they are sick and don’t gain weight, won’t produce milk, etc. • In Gulf coast states up to 23% of meat is lost due to liver flukes!
Pathological Damage • Mechanical Damage: Worms get numerous and clog up bile ducts.
Pathological Damage • Mechanical Damage: Worms get numerous and clog up bile ducts. – Hard to digest. – If bile can’t get out it will kill liver cells (necrosis of liver cells). – Calcium deposits in bile ducts fibrosis, and lots of scar tissue eventually causing calcification of ducts, making them useless.
Fasciola hepatica Pipestem fibrosis
Fasciola hepatica
White areas show cirrhosis in infected liver!
Big Picture for Major Pathology FIBROSIS!
2 ndary Pathology • Metacercariae penetrate intestine and migrate through body cavity (they don’t have a map!) through diaphragm and enter liver from outside. • Most make it but some become lost and become ECTOPIC INFECTIONS! • If encapsulated in wrong place (eyes, brain, skin, lungs) can cause seizures!
Symptoms • Adult liver flukes feed on bile duct epithelium and suck blood, so symptoms are anemia, hypoalbuminemia, hypoproteinemia.
Bottle Jaw
Symptoms • Diarrhea, edema, and enlarged liver. • Lower abdominal pain and discomfort (can last for up to 10 yrs after treatment and no probability of getting re-infected!
- Biohelminthes
- Where are liver flukes found
- Greg leos
- Metacercaria de fasciola hepatica
- Fasciola hepatica
- Anatomi porifera
- Morfologi trematoda
- Struktur tubuh cacing hati
- Fasciola hepatica
- Fasciola hepatica egg
- Fasciola hepatica
- Dorsoventrally flattened
- Struktur porifera
- Fasciola hepatica class
- Fasciola hepatica que es
- Pradera templada mapamundi
- Porto-systemic anastomosis
- Termasuk dalam filum
- Daur hidup fasciola hepatica
- Fasciola hepatica cdc
- Bacon of friendship
- Proserkoid
- Phylum of flukes
- Grados de encefalopatia hepatica
- Anticorpi heterofili mononucleoza infectioasa
- Ciroza hepatica decompensata faza terminala
- Encefalopatia uremica
- Corticoides hepatitis alcoholica
- Tidivaneh
- Etapa final de cirrosis
- Teorias de la encefalopatia hepatica
- Veia cava retro-hepática
- Fashiola hepatica
- Enemas de lactulosa en encefalopatia hepatica
- Tipuri ciroza
- Area nuda hepar
- Briofitas dominio
- Arteria hepatica communis
- Laevolac eps per diabetici
- Recessus hepaticus
- Proher natura limpieza hepatica
- Lipodiastema
- Ciroza hepatica decompensata portal si parenchimatos
- Patron citolitico
- Glicogenoliza hepatica
- Encefalopatia hepatica clasificacion
- Vena centralis hepatis
- Ciprofloxaino
- Steatoza hepatica moderata
- Enemas de lactulosa en encefalopatia hepatica
- Arteria radialis dextra