Malignant Epithelial Tumors Fig 9 1 Histological features

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Malignant Epithelial Tumors

Malignant Epithelial Tumors

Fig. 9. 1. Histological features of differentiation of the neoplasms Behavior Benign tumor Malignant

Fig. 9. 1. Histological features of differentiation of the neoplasms Behavior Benign tumor Malignant tumor Rate of growth Progressive, slow growth Local and expansive growth Rapid growth; Expansive and invasive growth; Local invasion Expansive and cohesive masses, well demarcated, no invading adjacent normal tissues Local invasive masses, infiltrating adjacent normal tissues Metastasis Absent Present Differentiation cytological features Well differentiated-are resembling with cell of origin cell differentiation failure Few mitosis Many mitosis, some abnormal N/C Ratio=(1/4) increased N/C Ratio=(1/1) Homogenous cell shape and size Cell and nuclear anizocytosis. pleomorphism; Differentiation and anaplasia; The rate of growth; Local invasion; Metastasis

Differentiation=morphological and functional similarity of neoplastic cells with cells of origin From: Stevens A.

Differentiation=morphological and functional similarity of neoplastic cells with cells of origin From: Stevens A. J Lowe J. Pathology. Mosby 1995 Normal Fig. 9. 2. Differentiation and anaplasia: WD

normal WD MD ND Fig. 9. 3. TM are more or less differentiated, showing

normal WD MD ND Fig. 9. 3. TM are more or less differentiated, showing various degrees of differentiation ranging from well-differentiated forms (BD) to non-differentiated (ND) or anaplastic forms.

Precancerous lesion-progression to neoplasia From: Stevens A. J Lowe J. Pathology. Mosby 1995 I

Precancerous lesion-progression to neoplasia From: Stevens A. J Lowe J. Pathology. Mosby 1995 I II III Fig. 9. 4. I-Normal epithelium; II-Dysplastic epithelium (DP mild, moderate and severe); CIS – carcinoma in situ; III-Microinvasive carcinoma; Invasive carcinoma.

CIS – carcinoma in situ-skin Fig. 9. 5. CIS-cell and nuclear pleomorphysm; intact BM.

CIS – carcinoma in situ-skin Fig. 9. 5. CIS-cell and nuclear pleomorphysm; intact BM.

Cancer cell morphology From cases of the Pathology Department - U. M. F. “Gr.

Cancer cell morphology From cases of the Pathology Department - U. M. F. “Gr. T. Popa” Iasi Fig. 9. 6.

Fig. 9. 7. Fig. 9. 6 -7. Cellular and nuclear abnormalities: Cellular and nuclear

Fig. 9. 7. Fig. 9. 6 -7. Cellular and nuclear abnormalities: Cellular and nuclear pleomorphism and size; Increase of nucleo/cytoplasmic ratio; Nuclear hypercromasia; Single or multiple nucleoli; Atypical mitoses.

Scuamocellular carcinoma From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 9. 8.

Scuamocellular carcinoma From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 9. 8. Vegetative carcinoma

Fig. 9. 9. Ulcerative carcinoma

Fig. 9. 9. Ulcerative carcinoma

Scuamocellular carcinoma From cases of the Pathology Department - U. M. F. “Gr. T.

Scuamocellular carcinoma From cases of the Pathology Department - U. M. F. “Gr. T. Popa” Iasi Fig. 9. 10. Ulcerative and invasive SCC into dermis

Fig. 9. 11. Fig. 9. 10 -11. Islands of polygonal atypical cells separated by

Fig. 9. 11. Fig. 9. 10 -11. Islands of polygonal atypical cells separated by a reduced connective stroma. By differentiation the tumoral cells fill with keratin disposed as concentric lamellae (keratin pearls).

Basal cell carcinoma (ulcus rodens) From: Stevens A. J Lowe J. Pathology. Mosby 1995

Basal cell carcinoma (ulcus rodens) From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 9. 12. Ulcus rodens

Fig. 9. 13. Ulcus rodens

Fig. 9. 13. Ulcus rodens

Basocellular carcinoma From cases of the Pathology Department - U. M. F. “Gr. T.

Basocellular carcinoma From cases of the Pathology Department - U. M. F. “Gr. T. Popa” Iasi Fig. 9. 14.

Fig. 9. 15. Fig. 9. 14 -15. The tumour cells resemble with basal layer

Fig. 9. 15. Fig. 9. 14 -15. The tumour cells resemble with basal layer cells. They penetrate basement membrane and form dermal tumoral islands separated by a reduced stroma.

Well differentiated adenocarcinoma of colon From cases of the Pathology Department - U. M.

Well differentiated adenocarcinoma of colon From cases of the Pathology Department - U. M. F. “Gr. T. Popa” Iasi Fig. 9. 16.

Fig. 9. 17. Fig. 9. 14 -15. The tumor wirh origin in the glandular

Fig. 9. 17. Fig. 9. 14 -15. The tumor wirh origin in the glandular epitheliumpenetrates muscularis mucosae and infiltrates the submucosa and muscular layer. The tumor is composed from tumoral glands separated by a reduced stroma.

Local invasion From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 9. 18.

Local invasion From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 9. 18. Invasion: infiltrative feature in adjacent tissues

Invasive colonic adenocarcinoma From cases of the Pathology Department - U. M. F. “Gr.

Invasive colonic adenocarcinoma From cases of the Pathology Department - U. M. F. “Gr. T. Popa” Iasi Fig. 9. 19. Invasion: infiltrative feature in adjacent tissues

Metastastatic ways of the tumor cells From: Stevens A. J Lowe J. Pathology. Mosby

Metastastatic ways of the tumor cells From: Stevens A. J Lowe J. Pathology. Mosby 1995 1. Local spread 2. Lymphatic dissemination 3. Vascular dissemination 4. Transcelomic dissemination Fig. 9. 20.

Fig. 9. 21. Grading is based on the degree of differentiation and the rate

Fig. 9. 21. Grading is based on the degree of differentiation and the rate of growth (number of mitosis) of tumour. Histological spectrum of cancer: Well differentiated --> Poor differentiated-->Undifferentiated Staging depends on: 1. the size of the primary tumour; 2. the extent of local spread; 3. the extent of distant spread

Lymphatic dissemination: lymph node metastases From: Stevens A. J Lowe J. Pathology. Mosby 1995

Lymphatic dissemination: lymph node metastases From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 9. 22.

Fig. 9. 23. Lymph node metastasis of adenocarcinoma: The tumoral cells invade lymph node

Fig. 9. 23. Lymph node metastasis of adenocarcinoma: The tumoral cells invade lymph node and form tumoral glands limited by an atypical epithelium. From cases of the Pathology Department - U. M. F. “Gr. T. Popa” Iasi

Fig. 9. 24. Blood dissemination Visceral metastases

Fig. 9. 24. Blood dissemination Visceral metastases

Fig. 9. 25.

Fig. 9. 25.

Malignant Bone tumors Malignant vs Benign Tumors RapidMalignant Bone tumors Malignant vs Benign Tumors Rapid
Conclustion Fig 8 Fig 5 Fig 6 FigConclustion Fig 8 Fig 5 Fig 6 Fig
Malignant Catarrhal Fever Malignant Catarrh Malignant Head CatarrhMalignant Catarrhal Fever Malignant Catarrh Malignant Head Catarrh
MALIGNANT CATARRHAL FEVER Synonyms Malignant Catarrhal fever MalignantMALIGNANT CATARRHAL FEVER Synonyms Malignant Catarrhal fever Malignant
Malignant Hyperthermia What is Malignant Hyperthermia Malignant hyperthermiaMalignant Hyperthermia What is Malignant Hyperthermia Malignant hyperthermia
MALIGNANT OVARIAN TUMOURS Prof Osman Donia Malignant epithelialMALIGNANT OVARIAN TUMOURS Prof Osman Donia Malignant epithelial
MALIGNANT BONE TUMORS Pazourek L Ondrek Osteosarcoma MalignantMALIGNANT BONE TUMORS Pazourek L Ondrek Osteosarcoma Malignant
Malignant Epithelial Tumors carcinoma Carcinomas are the commonestMalignant Epithelial Tumors carcinoma Carcinomas are the commonest
Benign and malignant epithelial tumors Done by DrBenign and malignant epithelial tumors Done by Dr
Epithelial Tissue Foldable POGIL Epithelial Epithelial Tissue POGILEpithelial Tissue Foldable POGIL Epithelial Epithelial Tissue POGIL
Epithelial Cells form Epithelial Tissue Structure Epithelial CellsEpithelial Cells form Epithelial Tissue Structure Epithelial Cells
Tumors Tumors Adenoma Benign Carcinomas malignant Others qTumors Tumors Adenoma Benign Carcinomas malignant Others q
REPRODUCTIV E SYSTEMMALE HISTOLOGICAL STRUCTURE HISTOLOGICAL STRUCTURE OFREPRODUCTIV E SYSTEMMALE HISTOLOGICAL STRUCTURE HISTOLOGICAL STRUCTURE OF
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Odontogenic tumors Markta Hermanov Odontogenic tumors n TumorsOdontogenic tumors Markta Hermanov Odontogenic tumors n Tumors
Intracranial Tumors Brain Tumors l Primary brain tumorsIntracranial Tumors Brain Tumors l Primary brain tumors
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