Environmental Disinfection A Review of Hydrogen Peroxide Vapor
- Slides: 43
Environmental Disinfection ~ A Review of Hydrogen Peroxide Vapor Technology Lessons from a Community Hospital Nancy Iversen, RN, CIC Director, Patient Safety & Infection Control Billings Clinic niversen@billingsclinic. org 406 -657 -4823
§ Not-for-profit, community owned and governed § Multi-specialty Physician Group Practice § 3, 750 employees § 260 employed physicians representing 50 specialties § 285 -bed hospital, 90 -bed LTCF § 7 regional branch clinic locations § Multi-state management affiliations and support services § Member of Mayo Clinic Care Network
Learner Objectives 1. Describe two unique characteristics, changing epidemiology, and environmental persistence of Clostridium difficile bacteria 2. Discuss two strategies that prevent the transmission of healthcare -associated Clostridium difficile and other pathogens 3. Describe the current environmental disinfection strategies and application of hydrogen peroxide vapor ~ BIOQUELL 4. Discuss advantages and disadvantages of hydrogen peroxide vapor disinfection technology Health Care, Education and Research
Examples of The Unseen What You Learn Will Creep You Out! The Dust Mite Photo courtesy of Janet Stout, Ph. D, Special Pathogens Lab Health Care, Education and Research
About Unseen Dust Mites • A typical mattress may have anywhere from 100, 000 to 10 million mites inside. • 10% of the weight of a two-year old pillow can be composed of dead mites and their droppings. Photo courtesy of Janet Stout, Ph. D, Special Pathogens Lab Health Care, Education and Research
Background • Environmental contamination contributes to transmission of healthcare-associated pathogens 1 • There is increased risk of acquisition of multidrug-resistant organisms in rooms where the previous occupant was colonized or infected with the organism 2, 3, 1. Weber D et el. Am J Infect Control 2010; 38: 25 -33 2. Drees M et al. Clin Infect Dis 2008; 46: 678 -85 3. Datta M et al. Arch Intern Med 2011; 171: 491 -494 4. Nseir S et al. Clin Microbiol Infect 2010; Nov 4
Background • Standard methods of cleaning and disinfecting surfaces in hospitalized patient’s rooms are sub-optimal 1, 2 • Novel technologies used to decontaminate patient rooms include 3, 4 – Hydrogen Peroxide Vapor (Bio. Quell) – Ultraviolet Light (UV-C Radiation) 1. Boyce JM et al. Infect Control Hosp Epidemiol 2010; 31: 99 -101 2. Carling PC. J Hosp Infect 2008; 68: 273 -274 3. Nerandzic MM et al. BMC Infect Dis 2010; 10: 197 4. Boyce JM et al. Infect Control Hosp Epidemiol 2008; 29: 723 -729 5. Havill NL. Infect Control Hosp Epidemiol 2012; 33(5): 000 -000
Contaminated Surfaces Can Contribute to transmission • Contaminated environmental surfaces can contribute to transmission of pathogens – By serving as a source from which healthcare workers contaminate their hands or gloves • Contaminated medical equipment that comes into direct contact with the patient can serve as a source of transmission Boyce JM et al. Infection Control Hosp Epidemiology 1997; 28: 1142 Bhalla A et al. Infection Control Hosp Epidemiology 2004; 25: 164 Hayden MK et al. Infection Control Hosp Epidemiology 2008; 29: 149 Passaretti CL, Clin Infect Dis; 2013; 56(1): 27 -35
Survival of Pathogens in the Environment Pathogens that survive well in the environment include: § Clostridium difficile § MRSA § VRE § Acinetobacter § Norovirus Hota B. , et al. Clin Infect Dis 2004; 39: 1182 Kramer A. , et al. BMC Infect Dis 2006; 6: 130
CDI Epidemiology / Issues • Rates Increasing world wide and in US – Outpacing MRSA Healthcare-associated Infections • Common epidemic C. difficile strain continues to be reported from hospitals in expanding list of states • More severe disease with – higher mortality – 6. 9% (30 days), 16. 7% at one year – higher readmissions – higher rates of colectomy in the elderly continues • Point-source outbreaks well described • Environment plays a role in transmission to other patients – Environmental survival of C. difficile spores is 5 months
Problem / Opportunity Clostridium difficile Infection (CDI) 2007 – December 31, 2014 Cost: $7179 / case (Scott, DR, Direct Medical Costs of HAI in US Hospitals, CDC, March 2009) Published incidence rate: 3. 8 -9. 5 cases per 10, 000 patient days (SHEA / IDSA Practice Guideline 2010).
Vancomycin Resistant Enterococcus (VRE) 1997 – March 31, 2011 2010 VRE Outbreak Investigation 6 new HA VRE cases June 2010 – October 2010 (no HAI VRE cases Jan – June ’ 10) • 3 HA colonizations (transmissions) • 3 HA infections PFGE Typing conducted suggested cross-transmission
Billings Clinic Hospital Study (August 2010) Phase 1: Baseline Environmental Cleaning Evaluation Study Design: Cleaned & empty room identified Terminal cleaning after 2 patient cycles Rooms marked with fluorescent marker DAZO, (Ecolab) Room evaluated • Marked 120 high-touch surfaces in 10 Patient Rooms IPS IPM ICC ATU ICC SSU ED (2 rooms, N & S) (1 room) (1 room) (2 rooms)
Study Results High Touch Surfaces Cleaning Study – Hospital Baseline ~ August 2010 High Touch Surfaces cleaned 61% (73/120) High Touch Surfaces not cleaned 39% (47/120) Ongoing Performance ~ January - December 2013 High Touch Surfaces cleaned 93. 2% (2116/2270) High Touch Surfaces not cleaned 6. 8% (154/2270) Health Care, Education and Research
Footboard Control Panel After Cleaning ~ Fluorescent marks remain
Computer Keyboard After Cleaning ~ Fluorescent marks remain
High Touch Environmental Surfaces Cleaning Verification January – April 15, 2014 98. 0% (1505/1536) Currently, DAZO fluorescent marking system is being used for EVS training and patient room disinfection verification. Process improvement ongoing.
High Touch Environmental Surfaces Cleaning Verification
Comparison of Disinfection Technology Hydrogen Peroxide Vapor (BIOQUELL) Efficacy § § Complete surface sterilization ensuring total elimination of pathogens EPA-registered room sterilant UV-C Radiation (Tru-D) § § Inactivates Validation Methodology Sporicical Compatibility Literature Support § § Inactivates bacteria, virus’, fungi C. difficile (20 minutes), VRE, Norovirus, MRSA, Acinetobacter (60 minutes), other Gram negs. § No verification of complete surface sterilization ~ 2 - 4 log kill (no higher than 4) Not EPA registered Log reduction of bacteria, virus’, fungi Yes. Inactivation of 6 -log Geobacillus stearothermophilus biological indicator (same method used to validate steam sterilizers) No. Biological Indicators not used to verify efficacy. Reference published studies to verify efficacy Yes ~ Kills C. difficile in 20 minutes No. 4 log reduction C. difficile in 50 minutes Safe for porous (fabrics, curtains) and nonporous materials & electronics Safe for porous (fabrics, curtains) and non-porous materials & electronics Substantial peer-reviewed, published scientific papers, abstracts Little scientific evidence. Limited application in HC
Comparison of Disinfection Technology Hydrogen Peroxide Vapor (BIOQUELL) UV-C Radiation (Tru-D) Purchase Price / Lease Option $56 k (lease to own option available) Includes Training $125 k Ongoing Operational Expense $20 k Hydrogen peroxide Tape $5 k Bulbs Data Tracking System Included Yes No Education & Training Provided On-site Support Additional Uses Safe in REI / IVF Laboratories Does not produce off-gassing ~ will not harm embryos Odor Light hydrogen peroxide odor Lingering odor ~ electrical fire
Bacterial Growth Before & after Decontamination ~ HPV vs. UV-C 68 Number of positive samples 70 N = 75 33 5 HPV vs. UVC (p <0. 0001) Havill NL, Moore BA, Boyce JM, Infect Control Hosp Epidemiol 2012; 33(5): 000 -000
Bacterial Growth After Decontamination 5 Surfaces using HPV vs. UV-C Number of positive samples Shadowed 12 10 Non-shadowed 5 4 2 2 0 1 1 1 HPV: Shadowed vs. non-shadowed (p =1) UVC: Shadowed vs. non-shadowed (p <0. 0001) Cultures with no growth before decontamination excluded Havill NL, Moore BA, Boyce JM, Hosp Infect Control Epidemiol 2012; 33(5): 000 -000
Log reductions C. difficile Log Reductions Achieved 3. 0 2. 5 2. 2 1. 7 1. 8 Havill NL, Moore BA, Boyce JM, Infect Control Hosp Epidemiol. 2012; 33(5): 000 -000
Hydrogen Peroxide Vapor (Bioquell) Process Evaluation Period Feb. 2011 • Room cleaned of visible soil • Ventilation & doorways sealed • Generator creates HPV from 35% Hydrogen Peroxide • Aeration unit catalytically converts HPV to oxygen and water vapor • Computer allows for process control and auto shut off
Bio. Quell Q-10 Room Sterilization System Hydrogen Peroxide Vapor (HPV)
Biological Indicator ~ Test Organism Geobacillus stearothermophilus • Purchase HPV 106 BI’s from outside lab • Run quarterly testing to verify efficacy • Expose 4 -5 HPV BI discs to 10 grams Hydrogen Peroxide • Incubate at 55 -600 C for 7 days • Chemical indicator pilot Ongoing verification of 106 log reduction
BIOQUELL Unit ~ Vent Sealing Device One to three units per room
Bio. Quell Unit in Use ~ ICU Room 2117 10 min. set-up; 90 min. cycle time; 5 min. tear down
Bio. Quell Trial ~ ICU Room 2117 10 min. set-up; 90 min. cycle time; 5 min. tear down (ICC Room ~ 4466 = 2 hrs, 40 min. / ICU 2114 = 75 min. )
Consumables (tape) from one room
UV-C Process • Room cleaned of visible soil • UVC device placed in the center of the room • Door closed • UVC (254 nm range) delivers 22, 000 u. W sec/cm 2 • Hand held device controls settings monitors the process
Tru-D Unit Setup ~ ICC Room 4465 5 min. set-up; 90 min. cycle time; 10 min. tear down
Tru-D Unit In-Use ~ ICU Room 2121 12 min. set-up; 54 min. cycle time; 10 min. tear down
Conclusions • HPV and UV-C significantly reduce bacterial contamination in patient rooms • HPV is significantly more effective than UV-C for the eradication of bacteria, including spores • UV-C is significantly less effective in shadowed areas from the device
Recommendation • Acquire Bio. Quell Q-10 Unit (HPV) technology for terminal room disinfection • Adopt objective measurement for cleaning & disinfection processes (e. g. fluorescent marker, ATP) – CDC recommendation, CMS requirement • Priority Applications ~ Terminal Disinfection – – – C. difficile rooms VRE rooms IVF Laboratory Equipment Disinfection ~ create Bio. Quell Room Norovirus Unused supplies in isolation rooms
Current Applications • Priority Applications ~ Terminal Disinfection – Clostridium difficile rooms (20 minute kill time) – VRE rooms – Norovirus – Emerging Multi-drug Resistant Organisms (MDRO) • ESBL, CRE • Acinetobacter (BIOQUELL kill time 60 minutes) • Other Resistant Gram-negative bacteria – IVF Laboratory in Surgery Center – Disinfection of Equipment / Unused Supplies • Unused medical supplies in isolation rooms Otter JA, Infect Control Hosp Epidemiol May 2013, Vol. 34, No. 5. ü 7 -9% contamination VRE/MDRO, None of the items were contaminated after HPV (p<. 02) Annual cost of supplies discarded at hospital discharge was $387, 055. – Currently run cycles in equipment storage rooms, gait belts.
BIOQUELL Cost Per Patient Room • • $56. 00 per 500 ml bottle of peroxide 2 – 500 ml bottles per room 1 tech at $17. 00/hour plus benefits Average time per room start to finish 3. 5 hours (set up 30 minutes) • Total cost per room = $185. 00 • Updated 2014 : $220. 00 new larger rooms – Room size ranges 40 -172 m 3 Health Care, Education and Research
BIOQUELL ~ 1 Year Cost Internally Managed Program • 281 patient rooms • 281 rooms at $185 per room • $51, 985. 00 • $5, 000 Annual P. M. and training • Total Annual Cost: $56, 985. 00 BIOQUELL Managed Program • $13, 500/month or • Total Annual Cost: $162, 000 Projected 2014 cost (larger rooms) § 25 rooms / month ~ 300 / year § $220. 00 per room + $5, 000 annual P. M. § Total Annual Cost: $71, 000 Health Care, Education and Research
BIOQUELL Use Summary • Began November 1, 2011 • 793 applications – – 75% C. difficile rooms 20% cycle cleans 4% other MDRO’s ~ VRE, Norovirus, ESBL 1% other (IVF, equipment rooms) • Average cycle time 3. 5 - 4 hours, 30 min. set-up • Perform initial terminal clean with bleach disinfectant • Run BI’s quarterly, evaluating CI’s (12 rooms)
Lessons Learned Advantages Disadvantages § Efficacy § Customer service decline § Efficacy validated § Recent breakdowns § Retain EVS personnel § Longer room turnover § Missed decontaminations § § Decontamination Specialists Substantial salary increase § § Staff acceptance high § § Gait belts Equipment storage areas § High census, velocity Breakdowns
Learner Objectives 1. Describe two unique characteristics, changing epidemiology, and environmental persistance of Clostridium difficile bacteria 2. Discuss two strategies that prevent the transmission of healthcare -associated Clostridium difficile and other pathogens 3. Describe the current environmental disinfection strategies and application of hydrogen peroxide vapor ~ BIOQUELL 4. Discuss advantages and disadvantages of hydrogen peroxide vapor disinfection technology Health Care, Education and Research
Questions?
Hand Hygiene Study Inter-rater Reliability Study November 2013 – February 28, 2014 Unit Results ATU 56% (51/91) ED 71% (85/119) FBC/LDRP 73% (19/26) ICC 66% (59/89) ICU 71% (49/69) IPM 74% (185/250) IPS 63% (95/150) NICU 76% (25/33) SSU 75% (53/71) Aspen 81% (44/54) TCU 33% (22/67) Dialysis 69% (20/29) Radiology 45% (5/11) Surgery Center 58% (11/19) Overall Performance 67% (712/1058)
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