Diclofnac Sold under the trade name Voltaren is

Diclofénac Sold under the trade name Voltaren, is a non steroidal uninflammatory drug used to treat pain and inflammatory diseases 12 13 11 14 15 9 10 8 3 7 6 4 5 2 1

H 12, 14 t d t t d H 2 OH

DQF-COSY H 12, 14 H 13 A C B D H 13 H 12, 14 D B 4/7? C A

H 12, 14 H 2 H 7 H 5 H 6 H 4 H 13 H 12, 14 ROESY H 13 DH 4 D-H 2 H 4 -H 2 H 6 B H 5 C 4/7? H 7 A

H 12, 14 NOESY H 2 H 12, 14 H 7 H 5 H 6 H 4 H 13 H 12, 14 H 13 H 4 H 6 H 5 H 13 H 6 H 4 H 2 -H 4 H 7 H 5 H 7

1 H-13 C H 2 HSQC C 2 H 12, 14 C 7 C 5 C 13 C 6 C 12, 14 C 4 H 13 H 4 H 6 H 5 H 7

1 H-13 C HMBC H 12, 14 H 13 H 4 H 6 C 2 -H 4 H 2 C 4 -H 2 C 8 -H 2 C 1 -H 2 H 5 H 7

1 H-13 C H 12, 14 H 13 HSQC H 4 1 H-13 C H 6 C 13 -H 13 C 12, 14 -H 12, 14 1 J C 6 -H 4 C 6 -H 6 C 4 -H 4 C 4 -H 6 C 8 -H 4 C 8 -H 6 cross peak C 10 -H 12, 14 HMBC H 5 H 7 C 7 -H 5 C 7 -H 7 C 5 -H 5 C 5 -H 7 C 3 -H 5 C 3 -H 7

H 12, 14 H 13 H 4 H 6 H 5 1 J=145 Hz for low pass filter 1 H-13 C HMBC Optimized for a long range constant of 6 Hz 1 J=170 Hz for low pass filter 1 H-13 C HMBC Cross peak between C 11, 15 -H 13 still missing Optimized for a long range constant of 4 Hz

Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation. 13 4 11 3 5 10 12 9 6 8 7 2 1

OH H 4, 6/H 5, 7 ? H 11, 12 H 13

H 2 O H 11, 12 DMSO H 13 H 2 H 9 H 10

DQF-COSY H 2 H 11, 12 H 13 H 10 H 9 H 2 H 9 H 10 H 13 H 11, 12

TOCSY H 2 H 11, 12 H 13 H 10 H 9 H 2 H 9 H 10 H 13 H 11, 12

NOESY H 11, 12 H 13 H 10 H 9 H 2 H 9 H 10 H 13

NOESY H 4, 6 H 11, 12 H 13 H 10 H 9 H 2 H 5, 7

ROESY

ROESY NOESY

H 4, 6 H 5, 7 1 H-13 C HSQC C 4, 6 -H 4, 6 C 5, 7 -H 5, 7 H 13 H 2 H 9 H 11, 12 H 10 C 13 -H 13 C 11, 12 -H 11, 12 C 10 -H 10 C 2 -H 2 C 9 -H 9

1 H-13 C H 2 HSQC 1 H-13 C H 9 HMBC H 10 H 13 H 11, 12 C 13 -H 13 C 13 -H 2 C 11, 12 -H 9 C 11, 12 -H 10 C 11, 12 -H 11, 12 C 10 -H 10 C 10 -H 9 C 2 -H 2 C 10 -H 11, 12 C 9 -H 9 C 2 -H 13 C 9 -H 11, 12

1 H-13 C HMBC H 9 H 2 H 10 H 13 C 4, 6 -H 2 C 5, 7 -H 9 H 4, 6 H 5, 7 C 3 -H 2 C 3 -H 13 C 8 -H 9 H 4, 6 H 5, 7 C 9 -H 5, 7 C 2 -H 4, 6 C 4 -H 6/C 6 -H 4 C 4 -H 4/C 6 -H 6 C 5 -H 7/C 7 -H 5 C 5 -H 5/C 7 -H 7 C 1 -H 2 C 8 -H 4, 6 C 3 -H 5, 7 C 1 -H 13

Furosemide sold under the brand name Lasix among others, is a medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It may also be used for the treatment of high blood pressure. 14 11 10 4 9 13 3 5 12 2 6 8 7 1

H 10 s dd s s dd dd

H 13 H 14 H 1 dd s H 11 H 10 dd dd s s H 12 • 13 -14 1, 6 -2, 0 • 12 -14 0, 6 -1, 0 • 12 -13 3, 2 -3, 8

C H 13 B DQF-COSY A H 13 H 14 H 12 H 11 • 13 -14 1, 6 -2, 0 • 12 -14 0, 6 -1, 0 • 12 -13 3, 2 -3, 8 H 7 H 9 H 10 H 12 H 13 H 14 C H 13 B AH 12 Long range H 10 -H 12 H 10

ROESY H 1 H 7 H 10 H 14 H 13 H 12

1 H-13 C H 10 HSQC C 10 H 7 C 12 C 13 C 4 C 7 C 14 H 1 H 4 H 13 H 12

~ ~ C 2=128. 5+9. 9+0. 4 -11. 5 -0. 1=127. 2 C 3=128. 5+6. 2 -2+1+4. 8=137. 5 C 4=128. 5+0. 4 -15. 6 -0. 1+0. 1=113. 3 C 5=128. 5+22. 6+1. 3 -3. 7=150. 3 C 6=128. 5+2. 4 -15. 6 -1. 9+0. 1=113. 5 C 7=128. 5+1. 6 -2. 0+1. 3+1=130. 4

1 H-13 C H 7 H 14 HSQC H 4 C 6 -H 4 C 12 -H 14 1 H-13 C HMBC H 10 H 13 H 12 109. 7 C 12 -H 12 C 12 -H 10 C 13 -H 13 C 4 -H 4 126. 8 C 2 -H 7 2 J H 7 -C 2 C 2 -H 4 C 7 -H 7 C 3 -H 4 C 14 -H 14 152. 8 C 5 -H 7 C 8 -H 7 C 11 -H 14 126. 8 136. 3 EXP CALC C 2 126. 8 127. 2 C 3 136. 3 137. 5 C 4 113. 8 113. 3 C 5 152. 8 150. 3 C 6 109. 7 113. 5 C 7 133. 7 130. 4 C 11 -H 10