Cardiac Muscle Physiology Faisal Mohammed MD Ph D

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Cardiac Muscle Physiology Faisal Mohammed, MD, Ph. D 1

Cardiac Muscle Physiology Faisal Mohammed, MD, Ph. D 1

Objectives: By The end of this lecture students should be able to: n Distinguish

Objectives: By The end of this lecture students should be able to: n Distinguish the cardiac muscle cell microstructure n Describe cardiac muscle action potential n Point out the functional importance of the action potential n Outline the intracellular calcium homeostasis 2

Wall of the heart Cardiac Muscle Cells

Wall of the heart Cardiac Muscle Cells

Cardiac Muscle Vs Skeletal Muscle v Syncytium structure v Gap Junction (electrical coupling) low

Cardiac Muscle Vs Skeletal Muscle v Syncytium structure v Gap Junction (electrical coupling) low resistance area v Poorly developed Sarcoplasmic reticulum (SR) v Transverse (T)Tubule more frequent in cardiac muscler v Rich in mitochondria v Low in nuclei 8

Permeability Changes and Ionic Fluxes During an Action Potential (skeletal Muscle) 9

Permeability Changes and Ionic Fluxes During an Action Potential (skeletal Muscle) 9

1 0 2 3 4

1 0 2 3 4

The Action Potential in Skeletal and Cardiac Muscle Figure 20. 15

The Action Potential in Skeletal and Cardiac Muscle Figure 20. 15

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Functional importance of Cardiac action potential n The decrease in conductance (permeability) of potassium

Functional importance of Cardiac action potential n The decrease in conductance (permeability) of potassium at phase 0 and 1 of the cardiac action potential contributes to the maintenance of depolarization in phase 2 (plateau) n The long absolute refractory period prevent the occurrence of tetanus (maintained contraction without a period of relaxation) in the cardiac muscle. n Skeletal muscle action potential is short that allows tetanus to occur

(inactivation gate) h Gate (activation gate) m Gate Activation gates open when the membrane

(inactivation gate) h Gate (activation gate) m Gate Activation gates open when the membrane potential becomes less negative and the inactivation gates close when the potential becomes less negative. The activation gate is fast but the inactivation is slow responding

The importance of calcium influx through the slow voltage gated calcium channels 19

The importance of calcium influx through the slow voltage gated calcium channels 19

Mechanism of Cardiac Muscle Excitation, Contraction & Relaxation

Mechanism of Cardiac Muscle Excitation, Contraction & Relaxation

Intracellular Calcium Homeostasis… 1 21

Intracellular Calcium Homeostasis… 1 21

Intracellular Calcium Homeostasis… 1 22

Intracellular Calcium Homeostasis… 1 22

Intracellular Calcium Homeostasis… 2 23

Intracellular Calcium Homeostasis… 2 23

Cardiac Muscle action potential Vs. Skeletal Muscle Ø Phase 0 –Depolarization phase (Na+ influx)

Cardiac Muscle action potential Vs. Skeletal Muscle Ø Phase 0 –Depolarization phase (Na+ influx) Ø Phase 1 partial repolarization (Not in skeletal) Ø Phase 2 Plateau (~ depolarization not in skeletal) slow calcium channels Ø Phase 3 fast repolarization phase (K+ repolarization() Ø Phase 4 resting membrane potential 24

Thank You 25

Thank You 25

Cardiac Muscle Physiology Faisal Mohammed MD Ph DCardiac Muscle Physiology Faisal Mohammed MD Ph D
Cardiac Muscle Physiology Faisal Mohammed MD Ph DCardiac Muscle Physiology Faisal Mohammed MD Ph D
Cardiac Muscle Physiology Faisal Mohammed MD Ph DCardiac Muscle Physiology Faisal Mohammed MD Ph D
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