Pediatric Procedural Sedation Jana Stockwell MD FAAP Childrens
- Slides: 58
Pediatric Procedural Sedation Jana Stockwell, MD, FAAP Children’s Sedation Services Children’s Healthcare of Atlanta Emory University School of Medicine 1
Why Not Sedate? • “I’m gonna be so fast they won’t even feel it. ” • “They’re just crying because they’re being held down. ” • “Children don’t feel pain” • “Children don’t remember pain” 2
Why Sedate? • • Efficacy Satisfaction Quality of study Do unto others… – Same injury, adults sedated more 3
Goals • Guard safety & welfare of child • Minimize physical discomfort & pain • Control anxiety, maximize potential for amnesia • Control behavior & movement to complete procedure • Return patient to state safe for discharge 4
CHOA @ Egleston Program • CCM & ED physicians • Dedicated radiology & H/O sedation nurses • 4 locations • 2 -3 docs/day • >3, 000 sedations/year 5
Overview • Definitions • Choose wisely – Pick your patient – Pick your drugs – Pick your “no’s” – Pick your battles • On the horizon 6
Definitions • 1992 AAP (Peds 1992; 898: 110) – Conscious Sedation – Deep Sedation • 1998 ACEP (Ann Emer Med 1998; 31: 663) – Procedural Analgesia & Sedation • 2006 AAP & AAPD (Peds 2006; 118: 2587 -2602) – Minimal = anxiolysis – Moderate = conscious – Deep – General anesthesia 7
Joint Commission 2000 • Level 1: Minimal – Respond normally to verbal commands – Cognitive function and coordination impaired 8
Joint Commission 2000 • Level 2: Moderate sedation / analgesia – Respond to verbal or gentle tactile stimuli – No intervention to maintain airway – Adequate spontaneous ventilation 9
Joint Commission 2000 • Level 3: Deep sedation / analgesia – Respond purposefully following repeated or painful stimulation – Ability to maintain ventilatory function may be impaired 10
Never Land • Level ~3. 5 Dissociative Sedation – Cataleptic state – Maintain protective reflexes – Retain spontaneous respirations 11
Joint Commission 2000 • Level 4: Anesthesia – Not arousable, even with painful stimuli – Independent ventilatory function often impaired 12
Remember, it’s a… 13
Providers • • “Licensed independent practitioner” Know drugs and antidotes Ability to monitor Capable of rescue Re-assess immediately before sedation Immediately available Not doing the procedure 14
(Appropriate) Patients • Painful Procedures – – – Bone marrow Bx, BMA Wound debridement Renal Bx Abscess I&D Fracture reduction Cardioversion • Movement an issue – – – Suture difficult area Radiographic images Auditory brain response LP Casting 15
Inappropriate Patients • Airway issues – Small, tight jaw – Airway obstruction • Respiratory issues • “Super quick” – Lacerations to be fixed with Dermabond Primum non nocere 16
Airway concerns Down’s Syndrome • Macroglossia • Small mouth • Small trachea • Atlanto-axial instability 17
Airway concerns Pierre-Robin Sequence Beckwith-Wiedemann Syndrome 18
Other concerns • Pneumonia, asthma, BPD, tracheomalacia, OSA, tachypnea • CCHD, CHF, hypotension • Central apnea, seizures • GERD, hepatic disease • Renal disease, dehydration, abnormal electrolytes • Sepsis 19
Patient Assessment • American Society Anesthesiology (ASA) class • Allergies • NPO status • Health evaluation 20
ASA classes • ASA 1: Healthy • ASA 2: Controlled dz of 1 system; <1 yo & healthy • ASA 3: 1 major system, poorly controlled • ASA 4: ≥ 1 severe dz, end-stage, constant threat to life • ASA 5: Moribund, imminent death 21
Allergies • Medications allergies – Previous anesthesia events? • Food allergies (egg, soy) • Tape, skin prep, etc 22
NPO duration & adverse events • Agrawal (2003) – 1, 014 sedations – 8. 1% in fasted, 6. 9% unfasted • Roback (2004) – 2, 085 sedations – No correlation by fasting time • Treston - 334 echos <6 mos (ketamine) – Fewer events if fasted <3 hours • Ingebo (1997)– 285 gastroscopies – No correlation of gastric volumes by times 23
NPO Status “…because the absolute risk of aspiration during procedural sedation is not yet known, guidelines for fasting periods before elective sedation should generally follow those used for elective general anesthesia. ” Pediatrics 2006; 118: 2587 24
NPO status (ASA) • • Solids, formula - 6 hours Clear liquids - 2 hours Breast milk - 4 hours Can take sip with meds 25
Preparation • Informed consent • Health evaluation – ROS – History (sedations? ) – Medications (including herbals) – Weight – VS, sat – Exam (airway, lungs, CV state, LOC) 26
Preparation • Additional person • “SOAPME” – Suction – Oxygen – Airways (BVM, oral, LMA, ETT) – Pharmacy (meds) – Monitors – Equipment (defibrillator, airway supplies, etc) 27
Reversal Agents • Naloxone – Competitively binds all 3 opiate receptors – IV, IM, SC, SL, ETT – 0. 1 mg/kg • Flumazenil – Can terminate paradoxical reactions – 0. 02 mg/kg – Lowers seizure threshold 28
Documentation & Monitoring • • • Time out Time-based record: Q 5 minutes SPO 2 & ETCO 2 HR BP LOC O 2 given Medications Interventions 29
Recovery and Discharge • • Continuous HR & sats until alert 1 person dedicated to patient Aldrete post-anesthetic score Post-sedation evaluation – Baseline cardiopulmonary status (VS) – Drinking – Level of consciousness – Locomotion / sitting • Written & verbal instructions 30
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Git ‘er done • • • Hypnotics Sedatives Ketamine Etomidate Propofol Nitrous oxide 32
Midazolam (Versed) • Anxiolysis • Dose– 0. 05 -0. 1 mg/kg IV, onset min – 0. 5 -1 mg/kg PO, onset 20 -30 min – 0. 3 -0. 4 mg/kg IN, onset 5 -15 min • Amnesia 92% - 98% • Paradoxical reactions • 1. 4% emergence / atypical reaction • onset at 14 min • relieved with flumazenil 33
Hypnotics • • Chloral hydrate Pentobarbital Methohexital Etomidate 34
Chloral hydrate • • • “Mickey Finn” 50 -80 mg/kg PO Onset approximately 15 minutes Duration 1 -2 hours Total max dose of 120 mg/kg or 1 g total for infants and 2 g total for children 35
Chloral hydrate • • • Amnesia? Gas Hyperactivity Deaths after discharge Carcinogen 36
Barbiturates • • Depress RAS No analgesia May be hyperesthetic Amnesia 37
Pentobarbital (Nembutal) • • • 1 -3 mg/kg IV, up to total of 6 mg/kg Sleep onset 1 -2 minutes Duration 30 -60 minutes Hypoxia, hypotension May give IM 4 -6 mg/kg Rage reaction – 1. 6% 38
Methohexital (Brevital) • 1 -3 mg/kg IV – Not painful – Additional doses at 0. 5 mg/kg – Drip 3 mg/kg/hr • Sleep onset 1 -2 min • Duration 10 -20 min – IM, PR ~90 minutes • 25 mg/kg PR • 5 -10 mg/kg IM 39
Methohexital • IV – Myoclonus 10% – Hiccups 10% • Rectal – 95% success – 6% apnea / desaturation – 3% hiccups Pediatrics 2000; 105(5): 1110 -4 40
Etomidate • Ultrashort-acting non-barbiturate imidazole hypnotic • 0. 2 -0. 3 mg/kg (<10 yrs), 0. 2 -0. 6 >10 yrs • Give over 30 -60 sec • Onset 30 sec • Duration 5 -10 min • Negligible hemodynamic effects • Amnesia 80% 41
Etomidate • • Myoclonus up to 30% Pain at injection site No analgesia Adrenal suppression – Blocks the normal stress-induced increase in adrenal cortisol production for 4 -8 hours • Increases EEG activation 42
Pentobarbital vs. Etomidate Adverse Event Pentobarb N = 396 Etomidate N = 444 Relative Risk (95% CI), p 18 (4. 5%) 6 (0. 9%) 1. 03 (1. 01, 1. 05) Desaturation 4 0 p=0. 03 Inadequate sedation 3 2 NS Apnea 2 1 NS Allergy/cough/secretions 4 0 NS Prolonged sedation 3 1 NS Stridor 1 0 NS Emesis 0 1 NS Too Deep 1 0 NS “not ideal” 11 1 p<0. 003 144 (139, 150) 34 (32, 36) Any Event* (p=. 005) Recovery time (min) 43
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Ketamine • Dissociative state – Related to PCP – Disconnects limbic system – Brainstem RAS not affected • • Analgesia – Sedation – Amnesia Does not impair laryngeal reflexes Bronchodilation inotropy, BP, SVR 45
Ketamine • • 1 -2 mg/kg IV, drip 1 -2 mg/kg/hr 3 -7 mg/kg IM Onset 1 min (nystagmus) Duration 15 min to 1 hour 46
Ketamine • Secretions – Consider glycopyrrolate (Robinul) • Vomiting • Emergence 12% • Contraindications – ICP, glaucoma, open globe – <3 months of age – History of psychosis, porphyria 47
Propofol • • • Sedative-hypnotic 1 -3 mg/kg bolus over ~2 min 5 mg/kg/hr Infants need higher dose Sedative – Profound relaxation – Anti-emetic – Antiepileptic properties Fidget Yawn Out 48
Propofol • • Alkaline -- STINGS Contraindicated - egg or soy allergy Hypotension Rare bradycardia, acidosis leading to sudden death • No analgesia • Green urine 49
Propofol in kids • Guenther (p. 783) – 291 outpatients – Median dose 3. 5 mg/kg – 4% jaw thrust – 1% BVM – 1 bradycardia to 57 • Bassett (p. 773) – 393 patients – Median dose 2. 7 mg/kg – 3% jaw thrust – 8% prolonged BP ↓ – 0. 8% BVM – 5% hypoxia Ann Emerg Med 2003; 42: 783 & 773 50
Nitrous Oxide (NO 2) • • Sedative & analgesic Fi. O 2 0. 25 -1. 0 50% nitrous maximum In combo with ANY other sedation or narcotic = deep sedation • Need scavenger equipment • 10– 15% vomiting 51
Dexmedetomidine • α 2 -adrenergic receptor agonist – Sedative & analgesic effects • Non-invasive procedures in 48 kids – 15 after failing CH and/or midazolam • Dosage: – 0. 5 -1. 0 mcg/kg over 5 -10 min – Infusion 0. 5 -1. 0 mcg/kg/hr • Recovery (w/o other med) 69 ± 34 min • Minimal cardio-respiratory effect PCCM 2005; 6: 435 -9 52
Adverse events • • • >30, 000 ped sedations (26 hospitals) All providers, non-OR 50% propofol Docs: 28% ER, 28% ICU, 19% anesth. 0 deaths, 1 arrest, 1 aspiration Per 10, 000 sedations: – 24 apnea – 2 airway consult – 10 intubation – 27 oral airway – 7 admitted – 64 BVM Peds 2006; 118: 1087 53
Reducing errors • • • Fewer than 3 medications Experience Double check dosages Expect adverse events Ready to rescue! 54
“Just say no” • • • Music Video Quiet room Darken if possible Parents present 55
Goals – Sedation outside the OR • Guard safety & welfare of child • Minimize physical discomfort & pain • Control anxiety, maximize potential for amnesia • Control behavior & movement to complete procedure • Return patient to state safe for discharge 56
Meetings • Pediatric Sedation Outside the Operating Room – Boston – September 15 -16, 2007 • 2 nd International Multidisciplinary Conference on Pediatric Sedation – Savannah, GA – March, 2008 Society for Pediatric Sedation 57
Questions? 58
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