Incorporation of Contracture Formation during Dermal Wound Healing
- Slides: 27
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model W. M. Boon Dr. ir. J. F. Vermolen Prof. dr. ir. C. Vuik Dr. ir. J. H. Dubbeldam D. Koppenol, MSc Challenge the future 1 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Opzet • Onderzoeksdoel • Biologisch proces • Wiskundig model • Componenten • Contractie • Resultaten • Conclusies & aanbevelingen Challenge the future 2 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Onderzoeksdoel • Wondgenezing • Vorming van nieuw weefsel • Sterkte afhankelijk van de mate van isotropie • Samentrekking van het weefsel (contractie) • Contractuur vorming • Modelleren van het volledige proces Challenge the future 3 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Gebied • Doorsnede huid • Wondgebied • 3 weken Challenge the future 4 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Biologisch proces Challenge the future 5 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Biologisch Proces t. PA PDGF Fibrine Leukocyten • Fibrine klont gevormd • Afbraak door t. PA • PDGF verspreidt via diffusie • Leukocyten arriveren • TGF-β wordt uitgescheden TGF-β • Chemoattractant • Fibroblasten arriveren • Myofibroblasten • Celdeling Fibroblasten en Myofibroblasten • Collageen productie • Contractie Collageen Contractie Challenge the future 6 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Wiskundig model Challenge the future 7 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Componenten: Cellen • Discrete schijven • Receptoren • Leukocyten • Bloedsomloop • Fibroblasten en myofibroblasten • Omliggend gebied • Celdeling • Beweging • Celdood Challenge the future 8 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Componenten: Cytokines • Diffusievergelijkingen • t. PA: Afbraak fibrine • PDGF: Aantrekking leukocyten • TGF-β: Aantrekking (myo)fibroblasten • Grid Challenge the future 9 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Componenten: Vezels • Fibrine • Collageen • Dichtheid en oriëntatie • Tensor Challenge the future 10 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Contractie • Samentrekking van het weefsel • Tijdelijke krachten • Fibroblasten en myofibroblasten • Permanente krachten • Myofibroblasten • Vorming van contractuur • Invloed op alle componenten • Discreet • Continu Challenge the future 11 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Tijdelijke krachten • Puntkracht • Kromme rond cel • Opsplitsen in lijnstukken • Meerdere puntkrachten • Formulering Challenge the future 12 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Permanente krachten • Contractuur vorming • Elementsgewijs • Timer per element Challenge the future 13 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Resultaten Challenge the future 14 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Celpopulaties Challenge the future 15 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Resultaten cellen Challenge the future 16 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Resultaten cytokines Challenge the future 17 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Resultaten cytokines Challenge the future 18 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Resultaten vezels Challenge the future 19 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Resultaten vezels Challenge the future 20 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Resultaten: Vezels Challenge the future 21 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Contractie Challenge the future 22 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Toename in tijdelijke krachten Challenge the future 23 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Conclusies en aanbevelingen Challenge the future 24 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Conclusies • Hybride model: Discrete cellen en continue concentraties • Verschillende stappen van wondgenezing • Toevoeging van contractie • Bewegend grid • Invloed op alle componenten • Vorming contractuur Challenge the future 25 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Aanbevelingen • Groter oppervlak • Tensor representatie verder benutten • Differentiatie tot myofibroblast • Model als basis Challenge the future 26 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Vragen Challenge the future 27 Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
Factors affecting wound healing ppt
Wound healing nutrition handout
Gaping earrings puncture
Types of inflammation
Primary union wound healing
Incised wound
Local factors of wound healing
Broken knuckle
Bladder neck contracture
Pauchet procedure
99 p
Volkmann's contracture
Equinus contracture
Explain ratification of a pre incorporation contract
Learnnowbiz
Asas place of incorporation
Procedure for incorporation of company
Zeta phi beta boule 2022 philadelphia
Legal status of company
Bill of rightts
Davis polk
Pre incorporation meaning
Profit prior to incorporation
Incorporation day.
Selective incorporation definition
Method of preparation of ointment
Characteristics of ophiuroidea
Functions of stem
