Photodynamic therapy PDT What is PDT The first
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Photodynamic therapy (PDT)
What is PDT? The first observation: bacterial colonies are killed when dyed by eozin (O. Raab, 1900). Definition (H. von Tappeiner, 1904): Cell inactivation in the presence of • photosensitizer • visible light • oxygen
The first utilisations of PDT First therapeutic experiments (H. von Tappeiner, 1905 -1911). Porphyria: consequences of impared degradation of porphyrins Enhanced accumulation of porphyrins in malignant tissues detected by fluorescence (~1960) First modern therapeutic applications Dougherty, 1968. , Roswell Park Memorial Hospital Buffalo, N. Y.
Depth of penetration of visible light in soft tissues
Typical photosensitizer families
Typical absorbance and fluorescence of porphyrins
Diagnostic application
abszorbancia, transzmittancia, relatív egységek Therapy Abszorbancia Terápiás szűrő transzmittanciája 300 400 500 600 hullámhossz, nm 700 800
Characteristic absorption spectra porphyrin chlorin bacteriochlorin
Schematic representation of PDT
Hem biosynthesis
PDT in therapy of malignancies Curative application only for small depth (initial stage) occurencies Palliative applications Adjuvant therapy after surgery Diagnostic application during surgery
Typical applications against malignancies • • • Skin cancers Urology: bladder carcinoma (prostate) Gastroenterology: Barrett esophagus Brain surgery Head and neck surgery Pulmonology
PDT in non-malignant diseases • Age related (wet) maculadegeneration • Psoriasis • To hinder restenosis after balloon angioplasty • Antibacterial applications • Cosmetic applications
Former research topics connected with PDT in the Department • Characterization of potential new photosensitisers (absorption and fluorescence spectra, triplet absorption spectrum and lifetime, quantum efficiency of singlet oxygen generation) • Effect of the microenvironment on the characteristics of photosensitisers • Measurement of diffusion of singlet molecular oxygen • Studies on the flexibilty of biological membranes.
Triplet – triplet absorption spectra of anthracene 0. 020 n-Hexán n-Heptadekán DMPC 0. 015 A 0. 010 0. 005 0. 000 390 400 410 420 (nm) 430 440
Triplet lifetime of prorphyrin in phospholipid membranes aerated conditions oxigen excluded o A 10 C 0, 03 o 20 C o 30 C A o 40 C 0, 02 26°C 35°C 45°C 55°C 0, 02 o 60 C 0, 01 0, 00 0 1 2 3 idő ( s) 4 5 0 0, 1 0, 2 0, 3 idő (ms) 0, 4 0, 5
- Humanistic therapy aims to
- Psychoanalytic vs humanistic
- Bioness integrated therapy system occupational therapy
- Pdt anwar tjen
- En 14351-1
- Rumah sungai lenggong
- Aga pdt
- Khotbah pdt gerry takaria
- Contchap
- 2 pdt
- Pdt anwar tjen
- Pdt manufacturing
- Prorphyrin
- Pdt alex
- Pdt product development
- 2 pdt
- Pdt rokotus
- Proverbios 30:18-19
- Mixer symbol pfd
- Bổ thể
- Từ ngữ thể hiện lòng nhân hậu
- Tư thế ngồi viết
- Thứ tự các dấu thăng giáng ở hóa biểu
- Thẻ vin
- Thể thơ truyền thống