Photodynamic Therapy Phototherapy The first who used the

Photodynamic Therapy

Phototherapy The first who used the light: Egyptians, Indians, Chinese and Grecee 1815. Carvin 1822. Sniadecki 1903. D. N. Finsen: Nobel Prize

Photochemotherapy Indians: Psoralea corylifolia Egyptians: Ammi majus

PDT history 1900. Oscar Raab 1905. H. von Tappeiner take in the PDT

Hematoporphyrin 1841. Sherer 1867. Thudicum 1871. Hoppe- Seyler

Hematoporphyrin 1924. Policard Auler and Banzer Figge and co workers: photodiagnosis

Why do some photosensitiziers localize selectively in tumors? Tumors have a larger interstital volume than normal tissues Tumors often contain a larger fraction of macrophages than normal tissues Tumors have a leaky microvasculature Tumors have poor lymphatic drainage The extracellular ph is low in tumors Tumors contain a relatively large amount of newly synthesized collagen Tumor tissue contains many receptors for lipoproteins

PDT treatment Use photosensitizing solution Irradiate Collect in cancer Selective tumour collapse

Porfirin

PDT mechanism Energy transport reactive oxygen

PDT mechanism Electron passing free radical

PDT mechanism photosensitizing Activation with light Introduce photosensitizing into the cell release reactive oxygen end free radical tissue necrosis or apoptozis

Other tumour therapy Surgery disadvantage: - can’t remove total the cancer - matastasis Radio- and chemotherapy disadvantage: - to hight degree damage - resistance

Photodynamic Therapy Advantage - selective destruction - not develop resistance Disadvantage - only use surface cancer - cell of small size

Other field of application - Arteriosclerosis - Germ, virus inanctivation - Gum inflammation - Blood sterilization - Water purification

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