Personalized Medicine Prof Dr Fridoon Jawad Ahmad King

Personalized Medicine Prof. Dr. Fridoon Jawad Ahmad King Edward Medical University

A Few Decades Ago Traditional Medicine Western Medicine Personalized Medicine

Currently Traditional Medicine Western Medicine Personalized Medicine

In a Few Decades Traditional Medicine Western Medicine Personalized Medicine

Why Personalized Medicine Not only we are different physically. We are also different biochemically.

Three Categories of Human Diseases • Genetically Determined • Determined by both Genetic and Environmental Factors • Environmentally Determined

Genetically Determined Genetically determined diseases are hereditary and are passed on from one generation to next. For example hemophilia, cystic fibrosis some types of cancers and probably the one most people here would have heard of thalassemia.

Determined by both Genetic and Environmental Factors Many common human diseases are “multifactorial” which have two components Genetic factor + Environmental Factor Diabetes and hypertension classical examples of this category Envoirnmental factors can change gene expression

Environmentally Determined Such diseases are caused by environmental agent such as an allergen or a pathogen. If look carefully even diseases considered caused by purely environmental influences may also have a genetic component e. g. asthma & susceptibility to certain microbial infections.

The Common Denominator GENETIC Implies the sequence DNA of patient Know thy sequence Likelihood

The Detection

Where Are My Min. IONs

Min. IONs to the Rescue

The principle

Full Genome Sequencing

The PCR Amplification Cycle 1 cycle = 3 steps

Animation

Knowing the Recipe Book Enough?

Do Have Live With Our Genes? Clustered Regularly Interspaced Short Palindromic Repeats

The Cellular Approach

Stem Cells 1) Stem cells are unspecialized cells that renew themselves. 2) Under certain physiologic or experimental conditions, Stem cells can be induced to become cells with special functions. 1) Embryonic 2) Adult 3) Customized

Customized Stem Cells

i. PSCs Expression of 4 genes in some cells can transform them into pluripotent stem cells. Cord Blood Stem Cells

Put Your Future In The Bank Which Bank? No tissue banking facilities in Pakistan. Why the Banks? Blood cancers Tissue replacement & engineering

Organ Engineering

Biomedical Sciences @ KEMU

Biomedical Sciences @ KEMU Ghazala Butt and Mehmood Chodhry

Biomedical Sciences @ KEMU Mustahsan Basheer and Mehmood Chodhry

Future is Now In just the last two years, the FDA approved four cancer drugs for use in patients whose tumours have specific genetic characteristics that are identified by a companion diagnostic test. Last year, FDA approved a new therapy for use in certain cystic fibrosis patients with a specific genetic mutation.

Three-dimensional (3 D) printing 2013, three-dimensional (3 D) printing was used to create a bio-resorbable tracheal splint for treating a critically-ill infant