Lumen Medical Technologies Inc Team Presentation NonInvasive Glucose

Lumen Medical Technologies Inc. • • • Introduction Vision System Description Test Results Problems

Introduction: Estimated Direct Costs of Treating Diabetes in British Columbia, Canadian Diabetes Association [1]

Introduction: A June 2005 online survey of Canadian Diabetes Association members revealed: [1] –

Introduction: • The current devices require blood samples. – – – Painful Inconvenient Messy

Vision: At Lumen Medical Technologies, we believe in using innovative solutions to build a

Radio Frequency Spectroscopy: • A source of electromagnetic signals - preferably a high frequency

System Description: Oscillator Receiver Transmitter BP filter Amplifier Phase/Gain comparator Amplifier ADC/LCD Driver LCD

System Description: • Digital vs. Analog – Why we chose analog: • Gain experience

Oscillator: ECS Inc. - ECS 100 AC The fundamental frequency is 10 MHz. The

Possible Solutions for the overshoot problem in the square wave • Schmitt Trigger •

Band-pass Filter: • • • Centre Freq = 30 MHz Bandwidth = 500 k.

Band-pass Filter: • Actual Response 1 d. B 30 MHz

Phase/Gain Comparator: Ideal Transfer Characteristics

LCD Driver/Display: • 0 -2 V input range • Low power consumption (500 u.

Test Solutions: • Human blood has 4 -10 mmol/L of glucose • Samples from

Test Results: • Non Linear (can use stock solutions for calibration) • Promising

Problems Encountered: • • • Wasted funds Timing issues Noise/Interference

Finances: • Total funding: $400 • Costs: $387. 41 • Balance: $12. 59

Production Cost: • • Screen/LCD Driver: $10 Gain Detection Unit: $30 Signal Generator: $2

Conclusion: • Inconclusive results • Require additional development and testing • Emerging market with

References: • [1] Canadian Diabetes Association, Diabetes Report, 2005. [online]. Available: http: //www. diabetes.

Slides: 32

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Lumen Medical Technologies Inc. Team Presentation Non-Invasive Glucose Measuring Device Members: Mehdi Abdollahi Jeff Chen Graham Laverty Deema Annyuk Connor Gillan Tony Tsai

Lumen Medical Technologies Inc. • • • Introduction Vision System Description Test Results Problems Encountered Project Finances Production Cost Conclusion Questions?

Introduction: Estimated Direct Costs of Treating Diabetes in British Columbia, Canadian Diabetes Association [1] • In British Columbia, approximately 248, 000 people are known to be living with diabetes. • The number is expected to increase to 305, 000 by 2010. • In 2004, diabetes cost B. C. ’s health care system $760 million, which is more than $2 million a day. • The complications of diabetes include heart disease and stroke, kidney disease, amputation and blindness. (There are more than 1, 000 amputations each year in B. C. )

Introduction: A June 2005 online survey of Canadian Diabetes Association members revealed: [1] – Over one in two Association members with diabetes (52%) reported that they pay personally for diabetes medications and supplies. – Almost one in two (46%) of Association members reported paying out-of-pocket expenses between $50 and $200 per month; one in four (25%) spent less than $50 a month. – Almost one in four (24%) of Association members reported there were diabetes drugs, supplies or devices that their doctor recommended, but that they could not afford to purchase and could not access through their insurance plan. – Those under age 40 with type 1 diabetes were more likely to be unable to afford medications and supplies recommended by their doctors.

Introduction: • The current devices require blood samples. – – – Painful Inconvenient Messy Risk of infection, other implications Must buy test strips (very costly – approximate $1 each) Solution? A non-invasive device

Vision: At Lumen Medical Technologies, we believe in using innovative solutions to build a device that can measure a patient’s blood sugar level without the need for any blood samples. This device can detect blood glucose concentration on skin contact.

Radio Frequency Spectroscopy: • A source of electromagnetic signals - preferably a high frequency pulse train that is rich in harmonics that generates a comb spectra is coupled via a probe pair to a sample that contains the target chemical. • The spectra of the original signal is then compared with the spectra of the signal that passed through the solution. • The signal that travels through the solution can have spectra with different energy levels than were present in the source signal. For example, some harmonic frequencies of the transmitted source signal may be returned attenuated or even amplified, probably due to certain non-linear dielectric processes occurring within the sample.