www ctspap gr Neutrophil GelatinaseAssociated Lipocalin as emerging

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Γ. Ν. Θ. «Γ. ΠΑΠΑΝΙΚΟΛΑΟΥ» ΚΛΙΝΙΚΗ ΧΕΙΡΟΥΡΓΙΚΗΣ ΘΩΡΑΚΟΣ-ΚΑΡΔΙΑΣ-ΜΕΓΑΛΩΝ ΑΓΓΕΙΩΝ ΔΝΤΗΣ Γ. Ε. ΔΡΟΣΟΣ ΣΥΓΓΡΑΦΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ Neutrophil Gelatinase-Associated Lipocalin as emerging biomarker of acute renal failure in renal transplant patient after coronary artery bypass surgery. Ampatzidou F, Koutsogiannidis C, Ananiadou O, Liosi M, Asteri T, Drossos G. J Cardiovasc Surg (Torino). 2012 Dec; 53(6): 805 -8. Acute renal injury (AKI) is a serious complication, which increases the risk of death after cardiac surgery. Although serum Cre is typically used for diagnosis of AKI, there are disadvantages in its use as renal marker. Neutrophil gelatinase-associated lipocalin (NGAL) is a protein of the lipocalin family and is expressed by neutrophils and other epithelial cells including segments of proximal collecting tubule (PCT). We present an interesting case of renal transplant patient under long term immunosuppressive therapy. He had already renal impairment of the transplant kidney (GFR 29, 3 ml/min/1, 73 m 2). He suffered from coronary artery disease without history of myocardial infraction and underwent elective coronary artery bypass grafting (CABG). Renal function was monitored also with NAGL, in order to avoid potential renal graft failure postoperatively. IF 1. 352

Γ. Ν. Θ. «Γ. ΠΑΠΑΝΙΚΟΛΑΟΥ» ΚΛΙΝΙΚΗ ΧΕΙΡΟΥΡΓΙΚΗΣ ΘΩΡΑΚΟΣ-ΚΑΡΔΙΑΣ-ΜΕΓΑΛΩΝ ΑΓΓΕΙΩΝ ΔΝΤΗΣ Γ. Ε. ΔΡΟΣΟΣ ΣΥΓΓΡΑΦΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ Noninvasive positive pressure ventilation for post-pneumonectomy early acute respiratory distress syndrome. Koutsogiannidis C, Ampatzidou F, Ananiadou O, Karaiskos T, Drossos G. Respir Care. 2012 Sep; 57(9): 1514 -6. doi: 10. 4187/respcare. 01493. Epub 2012 Feb 17. Acute respiratory distress syndrome (ARDS) remains a lethal complication after major lung resections. The reported mortality ranges from 50% to 100%, with increased incidence and mortality rates in pneumonectomy patients. The pathogenesis of early ARDS is still not fully understood and the majority of patients will require mechanical ventilation. A review of the literature reveals that the role of noninvasive positive pressure ventilation (NPPV) in ARDS after lung resection is unclear, in contrast to its well established benefits in other types of respiratory failure. NPPV is a technique of augmenting alveolar ventilation delivered by facemask, without introducing endotracheal tube. NPPV may reduce the need for endotracheal mechanical ventilation and improve clinical outcome in patients with acute respiratory failure after lung resection, avoiding complications related to intubation. We present a case of early ARDS following left-sided pneumonectomy, where Bi-level Positive Airway Pressure ventilation prompted a successful outcome. IF 1. 52

ΣΥΓΓΡΑΦΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ Aortic root aneurysm in an adult patient with aortic coarctation: a single-stage approach. Ananiadou OG, Koutsogiannidis C, Ampatzidou F, Drossos GE. Interact Cardiovasc Thorac Surg. 2012 Sep; 15(3): 534 -6. doi: 10. 1093/icvts/ivs 235. Epub 2012 May 30. Acute renal injury (AKI) is a serious complication, which increases the risk of death after cardiac surgery. Although serum Cre is typically used for diagnosis of AKI, there are disadvantages in its use as renal marker. Neutrophil gelatinase-associated lipocalin (NGAL) is a protein of the lipocalin family and is expressed by neutrophils and other epithelial cells including segments of proximal collecting tubule (PCT). We present an interesting case of renal transplant patient under long term immunosuppressive therapy. He had already renal impairment of the transplant kidney (GFR 29, 3 ml/min/1, 73 m 2). He suffered from coronary artery disease without history of myocardial infraction and underwent elective coronary artery bypass grafting (CABG). Renal function was monitored also with NAGL, in order to avoid potential renal graft failure postoperatively. Expected IF 1. 0

ΣΥΓΓΡΑΦΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ Acute type-a dissection in a patient with severe hemophilia A Diplaris K, Karfis E, Ampatzidou F, Ananiadou O, Vakalopoulou S, Madesis A, Asteri T, Drossos G J Cardiothorac Vasc Anesth. 2012 Aug; 26(4): 660 -3. doi: 10. 1053/j. jvca. 2011. 07. 017. Epub 2011 Sep 19. Acute type A aortic dissection is a life-threatening emergency condition associated with high mortality rates. Hemophilia type A is a relatively rare coagulation disorder requiring specific management. We report the case of a man with known severe hemophilia A, who was urgently treated for acute type A dissection. Challenging patient management issues are presented and therapeutic strategies are suggested for this rare combined clinical entity.