Neurotransmission Introduction to neurotransmitters channels and transporters Michael

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Neurotransmission: Introduction to neurotransmitters, channels, and transporters Michael P. Blanton Professor, Department of Pharmacology

Neurotransmission: Introduction to neurotransmitters, channels, and transporters Michael P. Blanton Professor, Department of Pharmacology and Neuroscience Chapters 4 and 6 in Neuroscience 5 th Edition text (Purves et al. )

GABAA Receptor – chloride conducting ligand gated ion channel target for general anesthetics, benzodiazepines,

GABAA Receptor – chloride conducting ligand gated ion channel target for general anesthetics, benzodiazepines, barbiturates, alcohol, etc

Synaptic Transmission -Ion Channels -ligand-gated ion channels -voltage-gated ion channels -ion channels gated by

Synaptic Transmission -Ion Channels -ligand-gated ion channels -voltage-gated ion channels -ion channels gated by p. H, heat, etc -Transporters -active transporters -ion exchangers - co-transporters

Neurotransmitters

Neurotransmitters

Synaptic Transmission -Ion Channels -ligand-gated ion channels -voltage-gated ion channels -ion channels gated by

Synaptic Transmission -Ion Channels -ligand-gated ion channels -voltage-gated ion channels -ion channels gated by p. H, heat, etc -Transporters -active transporters -ion exchangers - co-transporters

PN 04 BA 1. JPG The Patch Clamp Method

PN 04 BA 1. JPG The Patch Clamp Method

PN 04 BA 2. JPG The Patch Clamp Method

PN 04 BA 2. JPG The Patch Clamp Method

PN 04011. JPG Measurements of Ionic Currents Flowing through Single N+ Channels

PN 04011. JPG Measurements of Ionic Currents Flowing through Single N+ Channels

PN 04012. JPG Measurements of Ionic Currents Flowing through Single N+ Channels

PN 04012. JPG Measurements of Ionic Currents Flowing through Single N+ Channels

PN 04021. JPG Measurements of Ionic Currents Flowing through Single K+ Channels

PN 04021. JPG Measurements of Ionic Currents Flowing through Single K+ Channels

PN 04022. JPG Measurements of Ionic Currents Flowing through Single K+ Channels

PN 04022. JPG Measurements of Ionic Currents Flowing through Single K+ Channels

PN 04030. JPG Functional States of Voltage-Gated Na+ and K+ Channels

PN 04030. JPG Functional States of Voltage-Gated Na+ and K+ Channels

PN 04040. JPG Types of Voltage-Gated Ion Channels

PN 04040. JPG Types of Voltage-Gated Ion Channels

PN 04051. JPG Diverse Properties of K+ Channels

PN 04051. JPG Diverse Properties of K+ Channels

PN 04052. JPG Diverse Properties of K+ Channels

PN 04052. JPG Diverse Properties of K+ Channels

Structure of Kcs. A- a simple bacterial potassium channel

Structure of Kcs. A- a simple bacterial potassium channel

Structure of a voltage-gated sodium channel (Payandeh et al. 2011 Nature 475) Pathway to

Structure of a voltage-gated sodium channel (Payandeh et al. 2011 Nature 475) Pathway to binding sites for CNS drugs- local anesthetics (lidocaine) and anticonvulsant drugs (phenytoin and carbamazepine)

3 -D Structure of a human GABAAR: Ligand Gated Ion Channel

3 -D Structure of a human GABAAR: Ligand Gated Ion Channel

Structure of the AMPA Receptor: Ligand Gated Ion Channel

Structure of the AMPA Receptor: Ligand Gated Ion Channel

Postsynaptic responses mediated by NMDA receptors

Postsynaptic responses mediated by NMDA receptors

Transporters: ATPase pumps; Ion Exchangers, Co-transporters Structure of Dopamine/Na+ Cotransporter (DAT) complexed with the

Transporters: ATPase pumps; Ion Exchangers, Co-transporters Structure of Dopamine/Na+ Cotransporter (DAT) complexed with the Tricyclic Antidepressant (TCA) Nortriptyline Penmatsa et al (2013) Nature 503

PN 04102. JPG Ionic Movements Due to the Na+/K+ Pump

PN 04102. JPG Ionic Movements Due to the Na+/K+ Pump

Structure of a mammalian Na, K-ATPase Kanai et al. (2013) Nature 502

Structure of a mammalian Na, K-ATPase Kanai et al. (2013) Nature 502

Study Guide: -no structures! 1. Voltage-Gated Ion Channels- what are the properties of these

Study Guide: -no structures! 1. Voltage-Gated Ion Channels- what are the properties of these channels that contribute to synaptic transmission (ionselectivity; voltage-sensing, etc), what are the functional states. 2. Ligand-Gated Ion Channels- what are the properties of these channels that contribute to synaptic transmission (neurotransmitter selectivity; ion-selectivity; subunit composition, etc. ) that contribute to synaptic transmission. 3. Transporters- what are the different types of transporters and how do they each contribute to synaptic transmission.

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NEUROTRANSMITTERS NEUROTRANSMITTERS VIDEOS NEUROTRANSMITTERS 100 substances are knownNEUROTRANSMITTERS NEUROTRANSMITTERS VIDEOS NEUROTRANSMITTERS 100 substances are known
Das Gehirn SS 2009 Neurotransmission Neurotransmission Elektrische ChemischeDas Gehirn SS 2009 Neurotransmission Neurotransmission Elektrische Chemische
Steps of neurotransmission Steps of cholinergic neurotransmission TransductionSteps of neurotransmission Steps of cholinergic neurotransmission Transduction
Neurons Neurotransmitters and Neurotransmission Unit 2 Structure andNeurons Neurotransmitters and Neurotransmission Unit 2 Structure and
SPMT SELFPROPELLED MODULAR TRANSPORTERS SelfPropelled Modular Transporters SPMTsSPMT SELFPROPELLED MODULAR TRANSPORTERS SelfPropelled Modular Transporters SPMTs
OVERVIEW Neurotransmission Neurotransmitters Endocrine System Hormones Feedback SystemsOVERVIEW Neurotransmission Neurotransmitters Endocrine System Hormones Feedback Systems
NEUROTRANSMISSION Psych 11 Kabotoff What are neurotransmitters chemicalsNEUROTRANSMISSION Psych 11 Kabotoff What are neurotransmitters chemicals
NEUROTRANSMITTERS BY TIMOTHY AMEEFO INTRODUCTION Neurotransmitters are chemicalsNEUROTRANSMITTERS BY TIMOTHY AMEEFO INTRODUCTION Neurotransmitters are chemicals
Neurotransmitters An introduction Definition of Neurotransmitters Chemicals locatedNeurotransmitters An introduction Definition of Neurotransmitters Chemicals located
facetoface channels telephone channels internet channels tied andfacetoface channels telephone channels internet channels tied and
Gated Channels Cell Communication Ion channels Ion channelsGated Channels Cell Communication Ion channels Ion channels
Electronic Channels Direct versus Indirect Channels Direct ChannelsElectronic Channels Direct versus Indirect Channels Direct Channels
Gated Channels Cell Communication Ion channels Ion channelsGated Channels Cell Communication Ion channels Ion channels
Gated Channels Cell Communication Ion channels Ion channelsGated Channels Cell Communication Ion channels Ion channels
CHEMICAL MESSENGERS NEUROTRANSMITTERS VOCABS Neurotransmitters chemical messengers thatCHEMICAL MESSENGERS NEUROTRANSMITTERS VOCABS Neurotransmitters chemical messengers that
Cellular Processes Diffusion channels and transporters Cellular MembranesCellular Processes Diffusion channels and transporters Cellular Membranes
Ion Channels and Transporters in Renal Tubules GheunHoIon Channels and Transporters in Renal Tubules GheunHo
Cellular Processes Diffusion channels and transporters Cellular MembranesCellular Processes Diffusion channels and transporters Cellular Membranes
Ion Homeostasis Channels and Transporters An Update onIon Homeostasis Channels and Transporters An Update on
Ion Channels Active Transporters The proteins that createdIon Channels Active Transporters The proteins that created
Sodium Channels and Nonselective Cation Channels An IntroductionSodium Channels and Nonselective Cation Channels An Introduction
Dr Close CHANNELS DISTRIBUTION Introduction to Channels 1Dr Close CHANNELS DISTRIBUTION Introduction to Channels 1
An Introduction to Neurotransmission William Wisden Dept ofAn Introduction to Neurotransmission William Wisden Dept of