Food and Drug Interactions Khalid A AlMadani MPH

Food and Drug Interactions Khalid A. Al-Madani, MPH, DSc Consultant In Clinical Nutrition & Vice Present of Saudi Society for Food and Nutrition

Medications and Food Intake Drug Complications That Alter Food Intake

Medications and Food Intake (Conti. ) Medication That Alter Appetite

Diet-Drug Interactions and Absorption Medication Effects on Nutrient Absorption

Diet-Drug Interactions and Absorption (Conti. ) Drug-nutrient binding

Diet-Drug Interactions and Absorption (Conti. ) Altered acidity in the stomach

Diet-Drug Interactions and Absorption (Conti. ) Stomach Emptying Rate

Diet-Drug Interactions and Metabolism An increase in enzyme activity leads to a decrease in drug concentration and effect AND A decrease in enzyme activity leads to an increase in drug concentration and effect

Diet-Drug Interactions and Metabolism ( Conti. )

Diet-Drug Interactions and Metabolism ( Conti. ) A New Concern - Grapefruit n n Can cause more of a drug to be absorbed from intestine – even toxic levels May cause a drug not to work

Diet-Drug Interactions and Metabolism ( Conti. )

Diet-Drug Interactions and Metabolism ( Conti. ) Vitamin K and Warfarin Keep intake of foods containing Vitamin K constant n Vitamin K is high in spinach, kale, cauliflower, broccoli and other leafy greens n Also don’t take Vitamin K supplement n

Diet-Drug Interactions and Excretion Medication Effects on Nutrient Excretion

Diet-Drug Interactions and Excretion ( Conti. ) Dietary Effects on Medication Excretion

Diet-Drug Interactions and Toxicity

Diet-Drug Interactions and Toxicity ( Conti. ) MOA Inhibitors n n n No beer, red wine No cheddar, brie, mozzarella cheese No beef or chicken liver, cured meats, caviar or dried fish

Diet-Drug Interactions and Toxicity ( Conti. )

Conclusion Clinicians often overlook or fail to recognize diet-drug interactions, yet such interactions can raise health care costs and result in serious, and sometimes fatal, complications. With hundreds of diet-drug interactions known and more to be identified in the future, health care professionals must learn to take steps to prevent them.

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