PROCELLs Transdermal Cosmeceuticals p II SKIN Oct 23

PROCELL’s Transdermal Cosmeceuticals : p. II SKIN™ Oct. 23. 2014

● Brand Competitiveness of p. II-SKIN™ Fusion with innovative biotechnology § Innovativeness of Pro. Cell’s platform technology § Uniqueness and high performance of cosmeceutical active ingredients Pro. Cell’s top notch technology 1 § Worldwide IP application and registration § Global Partner : co-development of cosmeceutical active ingredients and PCT application 2 § Publication in peer-reviewed top scientific journals § Collaboration with global cosmetic giants and partnership with domestic - based cosmetic companies § Efficient transdermal delivery of active ingredients § Production of highly purified materials § Maximizing efficacy through skin cell activation § Efficacy and safety validated § Diverse application of active ingredients to cosmetics § Product safety is verified by certified clinical test institution 3 4 Collaboration with outstanding Global partners § Development of unique and highperformance active ingredients § Top quality and safety-guaranteed active ingredients Self supply of cosmeceutical active ingredients

Pro. Cell’s Platform Technology : MITT Basic Technology (MITT) Cargo (active ingredients) ▷ Antibodies ▷ Recombinant Proteins ▷ Peptides ▷ si. RNA or DNA ▷ Low MW chemicals ▷ Nanoparticles MTD Macromolecule Transduction Domain MITT Macromolecule Intracellular Transduction Technology

Skin and Skin Cell Permeable MTD Delivery of MTD-conjugated FITC into artificial skins Delivery of MTD-conjugated FITC into skin cells 3 Keratinocyte Melanocyte Fibroblast Cells

● p. II SKIN™ The novel platform for Cosmetics Anti-aging Anti-wrinkle Skin penetrating MTDs Whitening Growth Factors Skin-lifting Elasticity Moisturization Skin nourishment ● p. II-SKIN Pure to Skin si. RNAs Premium to Skin Precious to Skin § Paraben free § Mineral oil free Functional Peptides Natural Materials

Pro. Cell’s Platform Technology - MITT for Transdermal Delivery- MTD enhances skin permeability of cosmeceutical ingredients 1 st action ü MTD efficiently delivers active ingredients into stratum corneum and dermis 2 nd action ü MTD maximizes efficacy of active ingredients by intercellular or intracellular delivery

MTD-EGF Effect on Dermal Fibroblast Proliferation Cell proliferation (% of control) 200. 00 NHDF (Human) 150. 00 control 100. 00 50. 00 200. 00 Cell proliferation (% of control) Human Dermal Fibroblast (NHDF) 0 0. 01 0. 1 1 Procell MTD-EGFs (ng/m. L) 10 0. 1 ng/m. L Mouse Fibroblast (NIH 3 T 3) 150. 00 100. 00 1. 0 ng/m. L 50. 00 0 0. 01 0. 1 1 Procell MTD-EGFs (ng/m. L) 10 NIH 3 T(Mouse)

permeation rate (% of donor protein conc. ) Skin Permeability of MTD-EGF 0. 3% 0. 40 0. 20 0. 00 -0. 20 6 h 24 h GF MTD-GF 1 -0. 40 -0. 60 -0. 80 0. 01% -1. 00 -1. 20 EGF MTD-EGF Skin permeability of MTD-conjugated EGF is 30 times more than that of EGF after 24 hour treatment on artificial skin. 4

MTD-FGF 2 Effect on Dermal Fibroblast Proliferation Human Dermal Fibroblast (NHDF) Cell Proliferation (% of control) 150. 0 control 125. 0 100. 0 0. 8 ng/m. L 75. 0 50. 0 0 0. 1 1 10 100 Procell MTD-FGF 2 (ng/m. L) 3. 0 ng/m. L

Skin Permeability of MTD-FGF 2 0. 60 Permeation rate (% od donor protein conc. ) 1 h 24 h 0. 5% 0. 50 0. 40 0. 25% 0. 30 0. 20 0. 186 0. 163 0. 10 0. 00 FGF 2 MTD-FGF 2 MTD-GF 2 Skin permeability of MTD-conjugated FGF is 2 times more than that of FGF after 24 hour treatment on cadaver skin. 4

MTD-FGF 2 Effect on Dermal Fibroblast Proliferation Human Dermal Fibroblast (NHDF) § Cell migration by MTD-FGF 2 125. 0 100. 0 75. 0 150 50. 0 0 0. 1 1 10 100 Procell MTD-FGF 2 (ng/m. L) control 1 ng/m. L 3. 0 ng/m. L Cell proliferation was stimulated in human dermal fibroblast after 72 hrs treatment of MTD-FGFs. Number of Migrating Cells/Fields (% of control) Cell Proliferation (% of control) 5 ng/m. L control 150. 0 125 100 75 50 control MTD-FGF 2 treatment greatly enhanced the migration of HUVEC cell compared to control.

MTD-VEGF Effect on HUVEC Cell Proliferation and Migration 180 § Cell migration by MTD-VEGF HUVEC cell 25 ng/m. L control 140 120 100 80 175 control 0 3 ng 3 6 ng 6 12 ng 12 25 ng 25 Pcocell MTD-VEGF (ng/m. L) Number of Migrating Cells/Fields (% of control) Cell Proliferation (% of control) 160 150 125 100 75 50 control 5 ng/m. L 25 ng/m. L Increased cell proliferation of HUVEC cells was observed after 72 hrs treatment of MTD-VEGF. control MTD-VEGF treatment greatly enhanced the migration of HUVEC cell compared to control.

Skin Permeability & Collagen synthesis Efficacy of acetylpentapeptide-MTD § Cadaver skin permeability of acetylpentapeptide-MTD 14. 2 20 120. 0 Collagen synthesis (% of control) Human Cadaver Skin Flux rate (%) § In vitro collagen synthesis efficacy of acetylpentapeptide-MTD 15 10 5 0 Acetyl pentapeptide (AP) Into. Skin. Cell-AP® MTD-AP 115. 0 Conc. : 10 ppm Cell-line : NHDF 110. 0 105. 0 100. 0 95. 0 90. 0 control AP MTD-AP

p. II SKIN™ Solutions Products functions Regenerative Antiwrinkle Cream Anti-wrinkle Characteristics Advanced skin permeability of growth factors and peptides effective for skin elasticity : MEGF. MFGF, MVEGF, P 2 Skin-AP, P 2 Skin-AH Exceptional efficacy of anti-wrinkle and skin elasticity, compared to any other brand’s products New concept whitening ingredient by the collaboration with Institut Curie Bright Whitening Serum Whitening IP co-application and registration in International Cosmetic Ingredient Dictionary(ICID) New concept whitening serum strengthened with anti -wrinkle and skin elasticity Multi-factors Double Action High-performance - skin regeneration anti-aging anti-wrinkle whitening Development of high-performance ampule containing highly purified and concentrated ingredients Outstanding efficacy of anti-wrinkle and elasticity via customized ampule application Strengthened skin regeneration and elasticity with the simultaneous use of anti-wrinkle cream 5

The main ingredients of p. II-SKIN™ solutions ● Skin penetrating MTDs Skin penetration Intracellular delivery Pro. Cell patented MTDs M 085, M 1067, M 2173 A etc. Growth Factors Anti-aging/wrinkle Hair regrowth EGF, FGF-2, KFG, VEGF, IGF-1, SCF, PDGD etc. Functional proteins Hormones Anti-oxidation Slimming SOD, Irisin, FGF 21 etc. Functional Peptides Anti-wrinkle Whitening Acetyl & Amidated Di, Tri, Penta-peptides Natural Materials Moisturization Skin nourishment Plant extracts Natural origin proteins

PROCELL Anti-wrinkle Cream PROCELL Regenerative Anti-wrinkle Cream contains Pro. Cell’s platform technology-applied human growth factors such as EGF, FGF, and VEGF designed for efficient transdermal delivery and high-performance peptides for anti-wrinkle, and efficient delivery of these active ingredients into skin fibroblast cells helps skin regeneration and lifting. Pro. Cell Regenerative Anti-wrinkle Cream Anti-wrinkle cream developed using innovative human growth factors including EGF, FGF, VEGF effective for anti-wrinkle and cell regeneration Application Anti-wrinkle, skin cell regeneration, and anti-aging • MTD-applied skin permeable human growth factors Main Ingredients - MTD-EGF, MTD-FGF, MTD-VEGF, and other growth factors • MTD-applied skin permeable cell regenerative peptides - MTD-conjugated peptides • EGF(Epidermal Growth Factor): interacts with skin cell receptors and boosts proliferation of dermal fibroblast cells, and has function of skin regeneration, anti-aging, and anti-wrinkle Pro. Cell Regenerative Anti-wrinkle Cream - Boosting the proliferation of dermal fibroblast cells – anti-wrinkle effect - Enhanced skin elasticity through increased collagen synthesis - Reduction in transepidermal water loss(TEWL) * Skin irritation and cytotoxicity test completed Characteristics • FGF(Fibroblast Growth Factors) and VEGF(Vascular Endothelial Growth Factor) induce proliferation and differentiation of dermal fibroblast cells, and endotherial cells in blood vessel. Both factors enhance the synthesis of collagen and elastin, finally elevating skin elasticity. • Nonapeptide-29 Pentapeptide-4 and Nonapeptide-29 Hexapeptide 8: Pro. Cell’s patented peptides highly effective for collagen synthesis and skin lifting. 6

PROCELL Skin Regenerative Ampule p. II SKIN Multi-factors Double Action System is developed by the aid of Pro. Cell’s innovative platform technology designed for efficient transdermal delivery of bioactive ingredients, and p. II SKIN’s unique and optimized combination ratio of skin permeable growth factors helps effective skin regeneration and lifting. p. II SKIN Multi-factors Double Action contains highly purified and concentrated skin-permeable human growth factors effective for anti-aging and anti-wrinkle. Also, p. II SKIN Multi-factors Double Action helps skin regeneration via prompt and efficient delivery of human growth factors into skin Application • Anti-wrinkle, collagen synthesis, and improved skin elasticity • Whitening and moisturization • MTD-applied skin permeable human growth factors - MTD-EGF, MTD-FGF 2, MTD-VEGF Main Ingredients • MTD-applied skin permeable cell regenerative peptides - MTD-Acetylpentapeptide, MTD-Acetylhexapeptide • Niacinamide, Adenosine, Tranexamic acid • Ampule - Concentration of growth factors, based on their optimized combination ratio, and exceptional skin elasticity and regeneration - Anti-wrinkle and lifting effects on sagging skins - Whitening via anti-oxidants and whitening ingredients p. II SKIN Multi-factors Double Action - Boosting skin elasticity and regeneration - Anti-wrinkle and lifting effects on sagging skins - Whitening via anti-oxidants and whitening ingredients * Skin irritation and cytotoxicity test completed Characteristics • Regenerative Anti-wrinkle Cream - Improved skin elasticity and regeneration, after application of Ampule on deeply lined and sagging skins - Skin protection by reduction of Transepidermal Water Loss - Improved skin elasticity through collagen synthesis

PROCELL Whitening Serum Whitening serum was developed by the application of Pro. Cell’s innovation platform technology to Institut Curie’s new concept whitening ingredient. Its main functions are inhibition of melanin translocation and melanogenesis, and consequent reduction in melanin pigmentation Pro. Cell Bright Whitening Serum Pro. Cell Whitening Cream Serum Fresh Main ingredient of PROCELL WHITENING SERUM Was developed by the application of Pro. Cell’s Innovative platform technology to Curie’s new Concept whitening ingredient. Application Whitening, Anti-oxidant, and moisturizing • Co-development material with Institut Curie, France Main Ingredients - MTD-Kif 13 A • MTD-applied skin permeable human growth factors - MTD-EGF, MTD-FGF, MTD-VEGF • Inhibitory effect of melanin translocation • Melanogenesis inhibition PROCELL whitening Serum • Reduction in melanin pigmentation through the - Inhibitory effect of melanin translocation - Melanogenesis inhibition - Reduction in melanin pigmentation through the deoxidation and inhibition of melanin synthesis - Boosting collagen synthesis Skin irritation and cytotoxicity test completed Vol. : 30 m. L deoxidation and removal of produced melanin Characteristics • Boosting collagen synthesis • Strengthened moisturizing effect • Skin anti-aging effect using Omega ingredient rich in vegetable oil and lycopene 8

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