MEDS 371 Systems Neuroscience Pain System Dr D

MEDS 371, Systems Neuroscience Pain System Dr. D. O. Kim

dorsal horn of the spinal cord

CGRP: calcitonin gene related peptide; 5 -HT: serotonin

capsaicin VR-1: vanilloid receptor type 1

D synapse of a C-fiber (“C”) on the dendrite (“D”) of a dorsal-horn neuron. small vesicles: glutamate; large vesicles: neuropeptides. Kandel Fig. 24 -4 C

discriminative pain pathways (except face/head) anterolateral system (ALS); spinothalamic tract

spinal-cord hemisection Brown-Sequard’s syndrome section at lumbar spinal cord Purves

discriminative pain pathways: face/head trigem gang trigeminothalamic tract

trigeminal pathways somatosensory cortex trigeminothalamic tract pons medulla principal trigem. sensory nucleus trigeminal ganglion spinal trigem. tract & nucleus Haines Fig 8 -9

affect: n. the conscious subjective aspect of an emotion apart from bodily changes. [Webster’s New Collegiate Dictionary]

Two distinct aspects of the experience of pain thalamic nuclei: midline; anterior; mediodorsal modified from Purves Fig

thamaic nuclei CM: centromedian; LD: laterodorsal; LP: lateroposterior; MD: mediodorsal; VA: ventral anterior; VL: ventral lateral; VPL: ventral posterolateral; VPM: ventral posteromedial Netter

thalamus cingulate cortex hypothalamus Purves Fig. A-12

insula Purves Fig. A-10

affective pain pathways; unpleasant quality of pain

endogenous opioids: enkephalin; dynorphin; endorphin; in midbrain periaqueductal gray rost. vent. medulla spinal cord

descending control of pain pathways hypothalamus Kandel Fig 24 -11

descending control of pain pathways Purves Fig 10 -8 B

placebo effect a physiological response following the administration of an inert "remedy"

referred pain Kandel Fig. 24 -5 Purves

Methods for Rainville et al. , 1997 To immerse a hand in painfully hot water (47 °C) for 75 sec; Hypnosis: high or low unpleasantness

Activation of anterior cingulate cortex (ACC) by pain PET imaging of human brains Rainville et al 1997