Maturation of Agranulocytic Series Maturation of Monocytic and
- Slides: 25
Maturation of Agranulocytic Series Maturation of Monocytic and Lyphocytic Series 학습목표 1. 단구의 성숙과정 2. 림프구의 성숙과정 3. 단구와 림프구의 생성과 순환 4. T-림프구와 B림프구의 특성과 기능
단구과립의 성분 미세한 azure 과립이 세포질에 깔려있다. 1) Transport protein transferrin, transcobalamin 2) Nonspecific inflammatory agents(염증물질) lysozyme, endogenous pyrogens (interleukin-1) 3) Tissue activator(지혈인자) coagulation factor(V, VII, IX, X), tissue thromboplastin, plasminogen activator, complement(1 to 5) 4) Specific/humoral agents(조혈물질) CSF for CFU-GEMM, T, B cells, epithelial cells, erythropoietin 5) Storage(저장물질) iron, vitamin B 12 6) self-/non-self-recognition/defense agents(방어물질) interferon, tumor inhibitory factors such as tissue necrosis factor(TNF).
림프구계의 성숙 Pluripotential stem cell → Lymphoid stem cell → Thymus dependent → pre. Tcell →T lymphoblast → T Prolymphocyte → T cell Pluripotential stem cell → Lymphoid stem cell → Bursa equivalent → pre-B cell → B lymphoblast → B Prolymphocyte → B cell → Plasma cell
1) 림프아구(Lymphoblast) • 크기 : 10~20㎛ • 핵(nucleus) : 원형 또는 난형, 염색질 섬세, nucleoli 1~2개. • 세포질(cytoplasm) : scanty, basophilc stain(deep blue), 과립 없다. 2) 전림프구(Prolymphocyte) • 크기 : 9~18㎛, 원형 또는 난형, 염색질 농축, nucleoli 0~1개. • 세포질(cytoplasm) : more, vacuoles none or many, 과립 없다.
3) Large lymphocyte(Mature lymphocyte) • 크기 : 7~18㎛, 원형 또는 난형, nucleoli 없음. • Cytoplasm : Plentiful, vacuoles non or many, azure granules가 있을 수 있다. 4) Small lymphocyte(Old lymphocyte) • 크기 : 7~15㎛, 일반적으로 원형, chromatin coarse, nucleoli none. • Cytoplasm : Usually scanty, vacuoles none or many, 과립은 없다. Blue color
림프구의 분포 설명 Tissue T cells(%) B cells(%) 55~ 75(80%) 15~ 30(20%) Bone marrow < 25 > 75 Lymph > 75 < 25 Lymph node 75 25 Spleen 50 50 > 75 < 25 Blood Thymus
. T 림프구 및 B림프구의 특성 1) T-림프구 • T-림프구는 흉선 유래 세포. • Surface membrane of antigen markers:CD 2, CD 3, CD 7을 공통으로 가지고 있다. • Helper/inducer T cell은 CD 4 • Suppressor/cytotoxic T cell은 CD 8 • Delayed-type(반응성 T-cell) Killer T-cell • T-lymphoblast nucleus of antigen marker: Tdt(terminal deoxynucleotide transferase)
2) B-림프구 • B-림프구는 Bursa equivalent(Bursa of Fabricius)로 골 수 유래세포. • Surface membrane of antigen markers:CD 10, DR, CD 19, CD 20, CD 22가 있다. • B-lymphoblast nucleus of antigen marker: Tdt(Terminal deoxynucleotidyl transferase ) - 성숙된 림프구에서 발현되지 않으나 pre-B cell ALL질 환에서 발현된다 • Bursa of Fabricius:조류에 있는 총배설강의 상피성 발육체로서, 퇴축이전에는 체액성면역과 관련된 림프 구를 형성하는 조직(골수)이다.
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