Resveratrol accelerates erythroid maturation by activation of Fox

Resveratrol accelerates erythroid maturation by activation of Fox. O 3 and ameliorates anemia in beta-thalassemic mice by Sara Santos Franco, Luigia De Falco, Saghi Ghaffari, Carlo Brugnara, David A. Sinclair, Alessandro Matte’, Achille Iolascon, Narla Mohandas, Mariarita Bertoldi, Xiuli An, Angela Siciliano, Pauline Rimmelé, Maria Domenica Cappellini, Shaday Michan, Elisa Zoratti, Janin Anne, and Lucia De Franceschi haematol Volume 99(2): 267 -275 February 4, 2014 © 2014 by Ferrata Storti Foundation

Low-dose resveratrol hamper s cell growth and affects the pattern of erythroid maturation in normal erythropoiesis. Sara Santos Franco et al. Haematologica 2014; 99: 267 -275 © 2014 by Ferrata Storti Foundation

Low-dose resveratrol induces early erythroid maturation, activates FOx. O 3 a and inhibits Akt pathway (A) (Upper panel). Sara Santos Franco et al. Haematologica 2014; 99: 267 -275 © 2014 by Ferrata Storti Foundation

β-thalassemic erythropoiesis is affected by low-dose resveratrol, which induces early erythroid maturation. Sara Santos Franco et al. Haematologica 2014; 99: 267 -275 © 2014 by Ferrata Storti Foundation

β-thalassemic sorted CFU-E from cells cultured with low dose resveratrol results in the upregulation and activation of Fox. O 3 a and inhibition of Akt. Sara Santos Franco et al. Haematologica 2014; 99: 267 -275 © 2014 by Ferrata Storti Foundation

Effect of resveratrol on hematologic parameters and red cell index in β thalassemic (hbb 3 th/+) mice. Sara Santos Franco et al. Haematologica 2014; 99: 267 -275 © 2014 by Ferrata Storti Foundation

In vivo supplementation with resveratrol ameliorates β-thalassemic ineffective erythropoiesis, up-regulates Foxo 3 and peroxiredoxin-2 (Prdx 2). Sara Santos Franco et al. Haematologica 2014; 99: 267 -275 © 2014 by Ferrata Storti Foundation

In vivo supplementation with resveratrol ameliorates red cell morphology, increases red cell lifespan and reduces red cell membrane oxidative damage in β-thalassemic mice. Sara Santos Franco et al. Haematologica 2014; 99: 267 -275 © 2014 by Ferrata Storti Foundation