Gastrointestinal Complications related to enteral nutrition in Critically
- Slides: 22
Gastrointestinal Complications (related to enteral nutrition) in Critically Ill Patients Liz Goddard
Introduction Early enteral nutrition is recommended GIT Complications limit the ability to deliver adequate enteral nutrition affect morbidity and mortality
Risk Factors of GIT complications Shock Poor gut perfusion Gastroparesis - medication/disease process Impaired digestive enzyme secretion Increased gut permeability Cholestasis Diarrhoea Constipation
Metabolic Abnormalities Commonly Associated With Bowel Dysfunction Hyperglycaemia - Dysmotility noted at 150 mg/d. L - Dysmotility almost linear with blood glucose Hypokalaemia - k+ < 4 mmol/L Hypomagnasaemia - Mg < 2 mmol/L Hypophosphataemia - Po 4 < 3. 5 mg/dl p. H <7. 27 - Transporter activity affected first Positive fluid balance Negative fluid balance
GIT Complications Related to route of access for EN Abdominal distension Excessive gastric residues Vomiting Diarrhoea Constipation GIT haemorrhage
GIT Complications Aspiration Vomiting Abdominal distension 1. 9% 17. 9% 13. 2% Excessive gastric residues Diarrhoea Gastrointestinal haemorrhage Constipation 4. 7% 11. 3% 0. 9% 33 -55% Overall incidence GIT complications 11. 5 -15%
Gastrointestinal complications in adults and children Adults (%) Children (%) 50 -60 10 -20 Withdrawal of the nutrition 15 2 -7 Moderate Vomits 12 18 Abdominal distension, excessive gastric residues 13 -40 6 -15 Diarrhoea 10 -20 6 -11 Constipation 5 -80 ND Gastrointestinal haemorrhage 1 -2 0. 2 -1 Necrotizing enterocolitis, small bowel necrosis, nonocclusive ischaemia ND 0. 5 Frequency ND, no data
GIT Symptoms related to Enteral Feeds GIT symptoms : diarrhoea, bloating, abdominal discomfort Treatment : Change the method of EN delivery Rate of infusion - continuous vs bolus Feed sterility - closed systems - change delivery sets 12 hourly - strict hygiene Temperature - refrigeration
Route of Enteral nutrition Nasogastric Most widely used, easy to place, safe & well tolerated More physiological Nasojejunal Enables adequate energy delivery Reduces gastric residues Less time stopped for theatre , extubation Widely used for : GORD , Cardiacs, Disordered motility Difficulties with NJ More difficult to site & keep in, Do not give: Bolus feeds, Water – risk of necrozing bowel Complications: Misplaced, Perforation NO DIFFERENCE IN COMPLICATIONS
Continuous vs Bolus More physiological but ICU is not a normal environment! Difficulties with monitoring tolerance Requires additional nursing time Continuous Less time consuming, Easier to monitor May delay gastric emptying [adult ICU] Pro’s & Cons to both Often remains preference of unit Complication rate re gastric residues and tracheal aspiration were similar
Abdominal Distension and Increased Gastric Residues Excess gastric residues is a common complication Excessive gastric volume = >50% of volume of feed given in the previous 4 h Mechanism – 2° to alteration in GIT motility Aetiology – multifactorial - underlying illness – with cerebral, gastric, peritoneal disease - hyperglycaemia - diet – consistency, temp, osmolarity, composition - drugs – sedatives, catecholamines
Abdominal Distension and Increased Gastric Residues Complications - risk of aspiration - bacterial overgrowth - enteral feeds Treatment - reduce drugs that GIT motility - prokinetic agents erythromycin metaclopramide
Vomiting Incidence of GOR in critically ill children is high Aggravating factors: Increased gastric residues Supine position presence of NG tube dysfunction of LOS Recommendations: semi-recumbent position small calibre NG tubes nasojejunal feeds
Constipation No standard definition in critically ill children Incidence 33 -50% Aetiology - immobilization - dehydration - drug administration - diet low in fibre Constipation leads to abdominal distension and affects tolerance of feed
Constipation Treatment - use a diet with fibre - decrease drugs which GIT motility (opioids, sedatives, catecholamines, muscle relaxants) - laxatives, naloxone, enemas
Diarrhoea Incidence ? ? No standard definition in children - 1 loose stool 75% patients - ≥ 3 loose stools 35% patients - ≥ 4 loose stools 20% patients - ≥ 2 loose stools for 2 days 10% patients
Diarrhoea Causes: Diverse Infections Rotavirus clostridium difficile Antibiotics Drugs enteral nutrition high osmolar feed route of feed presence of hypoalbuminaemia underlying disease (shock)
Diarrhoea Treatment - Diet with fibre - Probiotics, prebiotics No studies in children
GIT Haemorrhage Incidence 1 - 10% Overt GIT bleed 10% Clinically significant bleed 1. 0% Risk Factors Organ failure High pressure ventilation Presence of a coagulopathy Treatment ? ? Prophylactic treatment to prevent GIT bleeds Cost ? increase in nosocomial pneumonia
Summary Early EN in critically ill children is recommended GIT complications are a major cause of inadequate enteral feeds SHOCK is a major risk factor for GIT complications No consensus on definitions of excessive gastric residues, constipation and diarrhoea Increased mortality in children with GIT complications Be aware of the complications : prevent or Rx early
Diarrhoea or abdominal bloating/pain complicating enteral nutrition Confirm diarrhoea. Check stool chart, discuss with nursing staff No diarrhoea, continue current management Yes diarrhoea evident Medication involvement? Antibiotics, sorbitolcontaining medications, laxatives Positive for C difficile? Yes, treat No Does formula contain FODMAPs? Yes switch to a FODMAPs-free formula Is osmolality of formula or feeding regimen high? Yes, trial continuous or low energy density formula Potential sites of contamination (HACCP)? Yes improve handling of formula and equipment Does modifying fiber content improve symptoms? Trial fiber or fiberfree formula No Consider elemental formula or parenteral nutrition if unsuccessful Figure 1. A suggested flow chart for the management of patients with diarrhoea or other abdominal symptoms complicating enteral nutrition. FODMAPs, Fermentable, Oliogo-, Di-, Mono-saccharides, And Polols; HACCP, Hazard Analysis and Critical Control Point guideline
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