Exploring Mendelian Genetics Chapter 11 3 Transmission of
- Slides: 63
Exploring Mendelian Genetics Chapter 11 -3
Transmission of characteristics from parents to offspring is called: A. Heredity B. Genetics C. Genes D. Homozygous
The science that studies HOW those characteristics are passed down from one generation to the next is called: A. Heredity B. Genetics C. Genes D. Homozygous
Mendel theorized that there must be ___ “factors” that control each trait. A. 1 B. 2 C. 3 D. 4
Different gene choices for a trait are called: A. Genes B. Homozygous C. Heterozygous D. Alleles
What is the term given when a trait is controlled by two contrasting alleles?
What is the term given when a trait is controlled by two identical alleles?
When a DOMINANT allele is paired with a recessive allele, the DOMINANT trait will mask the recessive trait. This is known as the Principal of ________? A. Traits B. Segregation C. Dominance
GENES are more complicated than Mendel thought ENVIRONMENT influences the ______________. expression of genes “Nature vs Nurture” = ____________ provide the plan Genes ______ for development, but how plan unfolds also depends on _______conditions. environmental _______
GENES are more complicated than Mendel thought Some traits have choices ______ MORE than 2 allele _____ MULTIPLE ALLELE TRAIT = __________ EX: blood type B ___ O A ___ Allele choices ___
GENES are more complicated than MENDEL thought Some traits are determined by MORE THAN ONE GENE ______________ POLYGENIC TRAIT = _________ EX: human height. intelligence, skin & eye color
GENES are more complicated than MENDEL thought Traits determined by ______ MORE than ONE gene have _________ many “______” in-between phenotypes There aren’t just SMART people and DUMB people…. there is a ________ whole range of intelligences in-between
GENES are more complicated than MENDEL thought KINDS OF DOMINANCE __________ COMPLETE DOMINANCE INCOMPLETE DOMINANCE __________ CO-DOMINANCE __________
COMPLETE DOMINANCE Dominant allele _______ masks _____ the ______ recessive one PATTERN ? Recessive allele ______ returns in a _____ratio in the 3: 1 ____ F 2 generation
INCOMPLETE DOMINANCE DON’T SEE expected _____ 3: 1 ratio in F 2 generation Heterozygous organisms with one _______ dominant and one recessive allele show a _____ BLENDED in-between trait
CO-DOMINANCE BOTH traits are expressed at _______ SAME TIME (___________) in heterozygote NO BLENDING ROAN A ____HORSE has _______ BOTH RED hair and _____ WHITE hair side by side
CO-DOMINANCE Both traits are expressed together (NO BLENDING) in heterozygote Persons with an A allele AND a B allele have blood type AB
REMEMBER Membrane proteins with _______ sugars attached that help cells recognize self = _______ GLYCOPROTEINS
BLOOD TYPES have more than 2 allele choices MULTIPLE ALLELE TRAIT = _____________ The pattern of sugars that is attached is determined by genes Allele choices are: A B O _____
BLOOD TYPES An A allele tells the cell to put “A” glycoproteins on its surface
BLOOD TYPES A B allele tells the cell to put a different “B” glycoprotein on its surface
BLOOD TYPES An O allele tells the cell NOT to put anything on the surface
A and B are CO-DOMINANT A cell with BOTH an A and a B allele has BOTH “A” and “B” glycoproteins on its surface
BLOOD TYPES & ALLELES GENOTYPE AA AO BB BO OO AB PHENOTYPE (BLOOD TYPE) A A B B O AB
DONOR BLOOD A and AB see A as “like me” B and O see A as Different! IMMUNE SYSTEM ATTACKS!
DONOR BLOOD B and AB see B as “like me” A and O see B as Different! IMMUNE SYSTEM ATTACKS!
DONOR BLOOD O can donate to ____ EVERY BLOOD TYPE = ___________ UNIVERSAL DONOR Nothing on surface to recognize as “NOT SELF” YOU DON’T HAVE ANYTHING I DON’T HAVE!
DONOR BLOOD Only AB sees AB as “like me” A, B, and O see AB as Different! IMMUNE SYSTEM ATTACKS!
AB can only GIVE to AB BUT. . . AB can RECEIVE FROM ______ EVERY BLOOD TYPE = ____________ UNIVERSAL RECIPIENT
BLOOD TYPE FREQUENCY IN USA A B AB O 42% 10% 4% 44%
ABO SYSTEM is NOT THE ONLY ONE + Rh Rh
OTHER BLOOD TYPES __________ IF: NO PROBLEMS Rh+ MOM is _____ & BABY is _____ Rh+ MOM is _____ Rh+ & BABY is ____ Rh-
PROBLEM IF: Can be a ______ Mom is _____ Rh- Baby is _____ Rh+ 1 st baby OK but few baby cells entering mom’s bloodstream put mom’s immune system on alert for + cells. Next + baby, mom’s immune system can attack baby as it is growing Mom given shot after 1 st birth prevents this
DIHYBRID CROSSES (2 traits)
Mendel also asked the question? Does the gene that determines if a seed is round or wrinkled have anything to do with the gene for seed shape? Must a seed that is yellow also be round?
MAKING A CROSS with TWO gene traits __________= DIHYBRID CROSS __________ A Punnett square for a DIHYBRID CROSS looks like this:
Figure 11 -10 Independent Assortment in Peas Section 11 -3 Go to Section:
LET’S MAKE A DIHYBRID CROSS HOMOZYGOUS YELLOW ROUND RRYY HOMOZYGOUS GREEN WRINKLED rryy 1. Figure ______ are out what _________ parent alleles 2. Choose ____correct_____ Punnett square _____ size 3. Put ______ in possible____________ parent gametes 4. Fill ______ in boxes with ___________ offspring combinations 5. Determine ______of_______& probabilities phenotypes ______ genotypes
LAW OF INDEPENDENT ASSORTMENT _____________ the factors are distributed to gametes independently of other factors
PRACTICE MAKING GAMETES WHAT ARE THE POSSIBLE GAMETES THIS PARENT CAN MAKE? HOMOZYGOUS ROUND YELLOW RRYY Each gamete should get one of each kind of gene R Y RY ____________ RY _______
PRACTICE MAKING GAMETES WHAT ARE THE POSSIBLE GAMETES THIS PARENT CAN MAKE? HOMOZYGOUS WRINKLED GREEN rryy Each gamete should get one of each kind of gene r y ry ____________ ry _______
PRACTICE MAKING GAMETES WHAT ARE THE POSSIBLE GAMETES THIS PARENT CAN MAKE? HETEROZYGOUS ROUND YELLOW Rr. Yy Each gamete should get one of each kind of gene R Y r y r. Y ____________ Ry _______
ry ry RY Rr. Yy Rr. Yy genotype 100% of offspring = _______ ROUND YELLOW phenotype ____________
MAKE ANOTHER CROSS HETEROZYGOUS ROUND YELLOW Rr. Yy X HETEROZYGOUS ROUND YELLOW Rr. Yy
POSSIBLE PARENT GAMETES? RY ry r. Y Ry
RY Ry r. Y ry RRYY RRYy Rr. YY Rr. Yy ____ 9 Round & Yellow Ry RRYy RRyy Rr. Yy Rryy 3 Round & ____ green r. Y Rr. Yy rr. YY rr. Yy 3 Wrinkled ____ & yellow rryy 1 wrinkled ____ & green RY ry Rr. Yy Rryy rr. Yy heterozygous dihybrid cross is a Sign of a ___________ 9: 3: 3: 1 ratio in offspring.
____ 9 ______ dominant TRAIT 1 ; ______ dominant TRAIT 2 3 ______ dominant TRAIT 1; _______ recessive ____ TRAIT 2 recessive TRAIT 1; _______ dominant 3 ______ TRAIT 2 1 ______ recessive TRAIT 1; _______ recessive 9: 3: 3: 1 _____ratio is a clue that it’s a ______________cross HETEROZYGOUS TWO gene
PRACTICE MAKING GAMETES for DIHYBRID CROSSES
What are the possible gametes? RRTT pure round & pure tall = _____ R T ______ RT What gametes can it produce?
Tt. RR Heterozygous Tall = _____ & pure round What are the possible gametes? ____ T R ____ t R ______ TR What gametes can it produce?
What are the possible gametes? Ttrr = _____ Hybrid tall & pure wrinkled ____ T r ____ t r ______ Tr What gametes can it produce?
What are the possible gametes? t. Rr =T _____ Heterozygous tall & hybrid round ____ T R ____ t r _____ t R ______ Tr What gametes can it produce?
HUMAN GENETICS 1. Human Genetics • Genes on chromosomes #1 -22 = AUTOSOMAL • Genes on sex chromosomes = SEX-LINKED
2. Human Genome Project • Completed in 2003 • International scientific project • Identified over 90% of our genes • HUGE science advancement
3. Sex Linked Genes • Sex-linked genes on Xchromosome are “X-linked genes” • Sex-linked genes on Ychromosome are “Y-linked genes” • X chr. much LARGER than Y chr. , so it carries more genes.
4. Sex-linked Disorders 1. Colorblindness = cannot distinguish certain colors (redgreen most common) • recessive X-linked • males more likely to be colorblind
WHY? • males only need 1 recessive X to be colorblind • females must have 2 recessive X to be colorblind
2. Hemophilia = disorder where blood does not clot • recessive X-linked • men more likely to have hemophilia
5. Detecting Human Genetic Disorders 1. Pedigree = diagram showing how a trait is inherited over several generations
Normal Male with condition Male CARRIER for condition
Normal Female with condition Female CARRIER for condition
Carrier = Person has 1 copy of a recessive allele • Does not show trait
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