Epithelial tissue Dr Anna L Kiss Department of

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Epithelial tissue Dr. Anna L. Kiss Department of Anatomy, Histology and Embryology Semmelweis University

Epithelial tissue Dr. Anna L. Kiss Department of Anatomy, Histology and Embryology Semmelweis University Budapest 2017

Tissues Clusters of cell having a. ) the same morphology, b. ) the same

Tissues Clusters of cell having a. ) the same morphology, b. ) the same function, c. ) same origin 4 basic tissue: - epithelial tissue - connective and supportive tissue - muscle tissue - nervous tissue

Epithelial tissue - polygonal, tightly attached cells - small amount of intercellular matrix -

Epithelial tissue - polygonal, tightly attached cells - small amount of intercellular matrix - junctions - membrana basalis -functions: isolation, protection vs. transport: surface covering polarized transport: secretion: glandular epithelium absorption: absorptive epithelium sensory, pigment epithelium -origin: all the 3 germ layers (ecto-, meso-, endoderm)

Epithelial tissue • surface covering • glandular • sensory • absorptive • pigment

Epithelial tissue • surface covering • glandular • sensory • absorptive • pigment

Surface covering epithelium: highly polarized cells Hemidesmosomes

Surface covering epithelium: highly polarized cells Hemidesmosomes

Surface covering epithelium simple: squamous cuboidal columnar pseudostratified

Surface covering epithelium simple: squamous cuboidal columnar pseudostratified

Simple squamous epithelium - endothel - kidney (Bowman capsule) - serous membranes (mesothelium) -

Simple squamous epithelium - endothel - kidney (Bowman capsule) - serous membranes (mesothelium) - lung (alveoli) - transport, diffusion or filtration (basement membrane !) - can be fenestrated

vessels - endothel

vessels - endothel

Simple cuboidal epithelium - kidney tubules - ducts of glands - active transport!

Simple cuboidal epithelium - kidney tubules - ducts of glands - active transport!

Simple columnar epithelium - uterus - stomach, intestine - special types (cilia, microvili, stereocilia

Simple columnar epithelium - uterus - stomach, intestine - special types (cilia, microvili, stereocilia on the apical membrane) - transport, absorption

Pseudostratified columnar epithelium Respiratory system: cilia protection

Pseudostratified columnar epithelium Respiratory system: cilia protection

Surface covering epithelium stratified epithelium: 1. ) squamous keratinized non-keratinized 2. ) cuboidal 3.

Surface covering epithelium stratified epithelium: 1. ) squamous keratinized non-keratinized 2. ) cuboidal 3. ) columnar ? urothelium (transient epithelium)

Stratified squamous epithelium - non-keratinized esophagus vagina - keratinized skin -minimal transport minimális, protection,

Stratified squamous epithelium - non-keratinized esophagus vagina - keratinized skin -minimal transport minimális, protection, isolation - the basal cells are dividing, the upper cells are dying

Stratified non-keratinized epithelium str. planocellulare str. polygonale, spinosum str. basale, cylindricum, germinativum

Stratified non-keratinized epithelium str. planocellulare str. polygonale, spinosum str. basale, cylindricum, germinativum

Stratified keratinized epithelium str. planocellulare: • str. granulosum • str. lucidum • str. corneum

Stratified keratinized epithelium str. planocellulare: • str. granulosum • str. lucidum • str. corneum thick keratine layer: isolation, protection

Stratified keratinized epithelium Str. lucidum Str. granulosum Str. spinosum Str. basale Str. corneum

Stratified keratinized epithelium Str. lucidum Str. granulosum Str. spinosum Str. basale Str. corneum

Transient epithelium (urothelium) -Urinary system (urether, urinary bladder, urethra) - simple or stratified? -

Transient epithelium (urothelium) -Urinary system (urether, urinary bladder, urethra) - simple or stratified? - EM: pseudostratified? STRATIFIED!!!

Glandular tissue - Specialized cells: secretion Endokrin- or exocrin glands

Glandular tissue - Specialized cells: secretion Endokrin- or exocrin glands

Exocrine glands Unicellular glands: – Endoepithelial: goblet cells – exoepithelial

Exocrine glands Unicellular glands: – Endoepithelial: goblet cells – exoepithelial

Secretory granules Golgi RER

Secretory granules Golgi RER

WGA Lectin immunohistochemistry

WGA Lectin immunohistochemistry

Exocrine glands simple compound tubular alveolar Tubulo-alveolar

Exocrine glands simple compound tubular alveolar Tubulo-alveolar

Exocrine glands -Secretory pathway - merocrine: continuous exocytosis (most of the glands) - apocrine:

Exocrine glands -Secretory pathway - merocrine: continuous exocytosis (most of the glands) - apocrine: modified sweat gland, mammary gland - holocrine: (the whole cell becomes secretum) sebaceous gland

Merocrine secretion

Merocrine secretion

Apocrine secretion

Apocrine secretion

Holocrine secretion

Holocrine secretion

Secretory pathways

Secretory pathways

Exocrine glands chemical composition of the secretum: a. ) serouos: protein strong basophyl staining

Exocrine glands chemical composition of the secretum: a. ) serouos: protein strong basophyl staining well developed r. ER

Exocrine glands b. ) mucus glands: carbohydrate well developed Golgi apparate

Exocrine glands b. ) mucus glands: carbohydrate well developed Golgi apparate

Exocrine glands c. ) mixed Gianuzzi demilune

Exocrine glands c. ) mixed Gianuzzi demilune

Salivary glands: duct system

Salivary glands: duct system

Intralobular: intercalated+striated ducts

Intralobular: intercalated+striated ducts

Felhasznált irodalom Röhlich Pál: Szövettan. Budapest, 1999 A szövettani képek a Humánmorfológiai és Fejlődésbiológiai

Felhasznált irodalom Röhlich Pál: Szövettan. Budapest, 1999 A szövettani képek a Humánmorfológiai és Fejlődésbiológiai Intézet gyűjteményéből származnak. Carola R, Harley JP, Noback CR: Human Anatomy & Physiology, Mc. Graw-Hill Inc. , USA, 1990 Wikipedia