The coagulation cascade Summary of stages Components of

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The coagulation cascade Summary of stages

The coagulation cascade Summary of stages

Components of the coagulation cascade – key Activated platelet Inactivated platelet Vessel wall TF

Components of the coagulation cascade – key Activated platelet Inactivated platelet Vessel wall TF Activated coagulation factor (various colours) Inactivated coagulation factor (various colours) VWF 2 2/25/2021 Von Willebrand factor (coiled conformation) Tissue factor V W F Von Willebrand factor (stretched conformation)

The coagulation cascade Initiation Amplification Propagation Stabilisation 3 2/25/2021

The coagulation cascade Initiation Amplification Propagation Stabilisation 3 2/25/2021

Initiation V VII TF Va TF X VIIa TF TF Prothrombin (II) Xa TF

Initiation V VII TF Va TF X VIIa TF TF Prothrombin (II) Xa TF Thrombin (IIa) 4 2/25/2021

Amplification VWF Thrombin (IIa) VIII TF V W F TF 2/25/2021 XI TF VIIa

Amplification VWF Thrombin (IIa) VIII TF V W F TF 2/25/2021 XI TF VIIa IX IXa XIa VIIIa X 5 V VIIIa Prothrombin (II) Xa Va Thrombin (IIa)

Propagation Prothrombin (II) TF Fibrinogen (I) V W F TF 6 2/25/2021 Fibrin (soluble)

Propagation Prothrombin (II) TF Fibrinogen (I) V W F TF 6 2/25/2021 Fibrin (soluble) XIIIa Thrombin (IIa) XIII

Stabilisation Fibrin (soluble) TF V W F TF 7 2/25/2021 Fibrin (insoluble)

Stabilisation Fibrin (soluble) TF V W F TF 7 2/25/2021 Fibrin (insoluble)

Initiation

Initiation

Initiation – 1 TF TF TF 9 2/25/2021

Initiation – 1 TF TF TF 9 2/25/2021

Initiation – 2 VII TF TF VIIa TF TF TF 10 2/25/2021

Initiation – 2 VII TF TF VIIa TF TF TF 10 2/25/2021

Multi-component enzyme complex ENZYME SUBSTRATE Ca 2+ CO-FACTOR Activated platelet surface 11 2/25/2021

Multi-component enzyme complex ENZYME SUBSTRATE Ca 2+ CO-FACTOR Activated platelet surface 11 2/25/2021

Initiation – 3 V VII TF Va TF X VIIa TF TF Xa TF

Initiation – 3 V VII TF Va TF X VIIa TF TF Xa TF 12 2/25/2021

Initiation – 4 V VII TF Va TF X VIIa TF TF Prothrombin (II)

Initiation – 4 V VII TF Va TF X VIIa TF TF Prothrombin (II) Xa TF Thrombin (IIa) 13 2/25/2021

Amplification

Amplification

Amplification – 1 VWF VIII TF TF 15 2/25/2021 VIIIa Thrombin (IIa)

Amplification – 1 VWF VIII TF TF 15 2/25/2021 VIIIa Thrombin (IIa)

Amplification – 2 VWF VIII TF VIIIa V W F TF 16 2/25/2021 TF

Amplification – 2 VWF VIII TF VIIIa V W F TF 16 2/25/2021 TF VIIa Thrombin (IIa)

Amplification – 3 VWF Thrombin (IIa) VIII TF VIIIa V W F TF 17

Amplification – 3 VWF Thrombin (IIa) VIII TF VIIIa V W F TF 17 2/25/2021 XI TF VIIa IX IXa XIa

Amplification – 4 VWF Thrombin (IIa) VIII TF V W F TF 2/25/2021 XI

Amplification – 4 VWF Thrombin (IIa) VIII TF V W F TF 2/25/2021 XI TF VIIa IX IXa XIa VIIIa X 18 V VIIIa Xa Va

Amplification – 5 VWF Thrombin (IIa) VIII TF V W F TF 2/25/2021 XI

Amplification – 5 VWF Thrombin (IIa) VIII TF V W F TF 2/25/2021 XI TF VIIa IX IXa XIa VIIIa X 19 V VIIIa Prothrombin (II) Xa Va Thrombin (IIa)

Propagation

Propagation

Propagation – 1 Prothrombin (II) TF Fibrinogen (I) V W F TF 21 2/25/2021

Propagation – 1 Prothrombin (II) TF Fibrinogen (I) V W F TF 21 2/25/2021 Fibrin (soluble) Thrombin (IIa)

Propagation – 2 Prothrombin (II) TF Fibrinogen (I) V W F TF 22 2/25/2021

Propagation – 2 Prothrombin (II) TF Fibrinogen (I) V W F TF 22 2/25/2021 Fibrin (soluble) XIIIa Thrombin (IIa) XIII

Stabilisation

Stabilisation

Stabilisation – 1 Fibrin (soluble) TF V W F TF 24 2/25/2021 Fibrin (insoluble)

Stabilisation – 1 Fibrin (soluble) TF V W F TF 24 2/25/2021 Fibrin (insoluble)

Stabilisation – 2 Fibrin (soluble) TF V W F TF 25 2/25/2021 Fibrin (insoluble)

Stabilisation – 2 Fibrin (soluble) TF V W F TF 25 2/25/2021 Fibrin (insoluble)

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