Coagulation Made Easy Alice Ma M D University
![Coagulation Made Easy Alice Ma, M. D. University of North Carolina-Chapel Hill Division of Coagulation Made Easy Alice Ma, M. D. University of North Carolina-Chapel Hill Division of](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-1.jpg)
![Coagulation Made Easy The PTT Pathway The PT Pathway Rather than thinking about the Coagulation Made Easy The PTT Pathway The PT Pathway Rather than thinking about the](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-2.jpg)
![Coagulation Made Easy The PTT Pathway The PT Pathway X The PT and the Coagulation Made Easy The PTT Pathway The PT Pathway X The PT and the](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-3.jpg)
![Coagulation Made Easy The PTT Pathway The PT Pathway V X Factor V is Coagulation Made Easy The PTT Pathway The PT Pathway V X Factor V is](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-4.jpg)
![Coagulation Made Easy The PTT Pathway The PT Pathway V X Prothrombin Thrombin Factor Coagulation Made Easy The PTT Pathway The PT Pathway V X Prothrombin Thrombin Factor](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-5.jpg)
![Coagulation Made Easy The PTT Pathway The PT Pathway V Thrombin, among other things, Coagulation Made Easy The PTT Pathway The PT Pathway V Thrombin, among other things,](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-6.jpg)
![The Common Pathway = Small Bills V+X II = prothrombin I = fibrinogen You The Common Pathway = Small Bills V+X II = prothrombin I = fibrinogen You](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-7.jpg)
![Coagulation Made Easy: The PT PT has one less letter than PTT, and PT Coagulation Made Easy: The PT PT has one less letter than PTT, and PT](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-8.jpg)
![Coagulation Made Easy: The a. PTT The PTT Pathway XII The PTT pathway has Coagulation Made Easy: The a. PTT The PTT Pathway XII The PTT pathway has](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-9.jpg)
![Coagulation Made Easy: The a. PTT The PTT Pathway T Well, just remember that Coagulation Made Easy: The a. PTT The PTT Pathway T Well, just remember that](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-10.jpg)
![Coagulation Made Easy: The a. PTT The PTT Pathway Twelve Eleven Nine Eight Ten Coagulation Made Easy: The a. PTT The PTT Pathway Twelve Eleven Nine Eight Ten](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-11.jpg)
![Coagulation Made Easy: PT and PTT Both Prolonged The PTT Pathway The PT Pathway Coagulation Made Easy: PT and PTT Both Prolonged The PTT Pathway The PT Pathway](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-12.jpg)
![Coagulation Made Easy: Only PT Prolonged 7 Deficiency of Factor VII will prolong the Coagulation Made Easy: Only PT Prolonged 7 Deficiency of Factor VII will prolong the](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-13.jpg)
![Coagulation Made Easy: Only PTT Prolonged Twelve Eleven Nine Eight Ten Deficiencies of Factors Coagulation Made Easy: Only PTT Prolonged Twelve Eleven Nine Eight Ten Deficiencies of Factors](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-14.jpg)
![What Matters Clinically XII XI IX VIII VII X V Thrombin Fibrinogen Fibrin • What Matters Clinically XII XI IX VIII VII X V Thrombin Fibrinogen Fibrin •](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-15.jpg)
![Coagulation Made Easy: The Mixing Study • Useful to differentiate etiologies of prolonged clotting Coagulation Made Easy: The Mixing Study • Useful to differentiate etiologies of prolonged clotting](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-16.jpg)
- Slides: 16
![Coagulation Made Easy Alice Ma M D University of North CarolinaChapel Hill Division of Coagulation Made Easy Alice Ma, M. D. University of North Carolina-Chapel Hill Division of](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-1.jpg)
Coagulation Made Easy Alice Ma, M. D. University of North Carolina-Chapel Hill Division of Hematology
![Coagulation Made Easy The PTT Pathway The PT Pathway Rather than thinking about the Coagulation Made Easy The PTT Pathway The PT Pathway Rather than thinking about the](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-2.jpg)
Coagulation Made Easy The PTT Pathway The PT Pathway Rather than thinking about the intrinsic and the extrinsic pathways, think about the PTT and the PT pathways.
![Coagulation Made Easy The PTT Pathway The PT Pathway X The PT and the Coagulation Made Easy The PTT Pathway The PT Pathway X The PT and the](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-3.jpg)
Coagulation Made Easy The PTT Pathway The PT Pathway X The PT and the PTT pathway meet at Factor X, because “X” marks the spot.
![Coagulation Made Easy The PTT Pathway The PT Pathway V X Factor V is Coagulation Made Easy The PTT Pathway The PT Pathway V X Factor V is](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-4.jpg)
Coagulation Made Easy The PTT Pathway The PT Pathway V X Factor V is a cofactor for Factor X, and you can remember this because V fits into the notch of the X.
![Coagulation Made Easy The PTT Pathway The PT Pathway V X Prothrombin Thrombin Factor Coagulation Made Easy The PTT Pathway The PT Pathway V X Prothrombin Thrombin Factor](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-5.jpg)
Coagulation Made Easy The PTT Pathway The PT Pathway V X Prothrombin Thrombin Factor Xa converts prothrombin (Factor II) into thrombin, the most important enzyme on the planet.
![Coagulation Made Easy The PTT Pathway The PT Pathway V Thrombin among other things Coagulation Made Easy The PTT Pathway The PT Pathway V Thrombin, among other things,](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-6.jpg)
Coagulation Made Easy The PTT Pathway The PT Pathway V Thrombin, among other things, converts the soluble molecule fibrinogen into a solid fibrin clot. X Prothrombin Thrombin Fibrinogen Fibrin
![The Common Pathway Small Bills VX II prothrombin I fibrinogen You The Common Pathway = Small Bills V+X II = prothrombin I = fibrinogen You](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-7.jpg)
The Common Pathway = Small Bills V+X II = prothrombin I = fibrinogen You can remember the factors in the common pathway by remembering the bills in your wallet smaller than a $20. Don’t forget the $2 bill!
![Coagulation Made Easy The PT PT has one less letter than PTT and PT Coagulation Made Easy: The PT PT has one less letter than PTT, and PT](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-8.jpg)
Coagulation Made Easy: The PT PT has one less letter than PTT, and PT values are shorter than PTT values, because the pathway is shorter. It means that the PT pathway is also shorter. This means that there’s fewer steps to remember, and this is lucky, so the lucky PT pathway uses lucky Factor 7 to activate Factor X. Prothrombin The PT Pathway 7 V X Thrombin Fibrinogen Fibrin
![Coagulation Made Easy The a PTT The PTT Pathway XII The PTT pathway has Coagulation Made Easy: The a. PTT The PTT Pathway XII The PTT pathway has](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-9.jpg)
Coagulation Made Easy: The a. PTT The PTT Pathway XII The PTT pathway has all those hideous roman numerals. . . XI How are we going to remember them? Hmmmmm. . . IX VIII Prothrombin V X Thrombin Fibrinogen Fibrin
![Coagulation Made Easy The a PTT The PTT Pathway T Well just remember that Coagulation Made Easy: The a. PTT The PTT Pathway T Well, just remember that](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-10.jpg)
Coagulation Made Easy: The a. PTT The PTT Pathway T Well, just remember that the PTT is a basic TENET of hematology. E N E Prothrombin TENET stands for. . . T V X Thrombin Fibrinogen Fibrin
![Coagulation Made Easy The a PTT The PTT Pathway Twelve Eleven Nine Eight Ten Coagulation Made Easy: The a. PTT The PTT Pathway Twelve Eleven Nine Eight Ten](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-11.jpg)
Coagulation Made Easy: The a. PTT The PTT Pathway Twelve Eleven Nine Eight Ten Prothrombin V X Thrombin Fibrinogen Fibrin
![Coagulation Made Easy PT and PTT Both Prolonged The PTT Pathway The PT Pathway Coagulation Made Easy: PT and PTT Both Prolonged The PTT Pathway The PT Pathway](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-12.jpg)
Coagulation Made Easy: PT and PTT Both Prolonged The PTT Pathway The PT Pathway V X Prothrombin (II) Fibrinogen These factors are in the common pathway.
![Coagulation Made Easy Only PT Prolonged 7 Deficiency of Factor VII will prolong the Coagulation Made Easy: Only PT Prolonged 7 Deficiency of Factor VII will prolong the](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-13.jpg)
Coagulation Made Easy: Only PT Prolonged 7 Deficiency of Factor VII will prolong the PT but not the PTT.
![Coagulation Made Easy Only PTT Prolonged Twelve Eleven Nine Eight Ten Deficiencies of Factors Coagulation Made Easy: Only PTT Prolonged Twelve Eleven Nine Eight Ten Deficiencies of Factors](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-14.jpg)
Coagulation Made Easy: Only PTT Prolonged Twelve Eleven Nine Eight Ten Deficiencies of Factors 12, 11, 9, and 8 will prolong the PTT and not the PT. Remember that Factor 10 is in the common pathway, and affects BOTH the PT and the PTT.
![What Matters Clinically XII XI IX VIII VII X V Thrombin Fibrinogen Fibrin What Matters Clinically XII XI IX VIII VII X V Thrombin Fibrinogen Fibrin •](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-15.jpg)
What Matters Clinically XII XI IX VIII VII X V Thrombin Fibrinogen Fibrin • Deficiencies of Factor XI, IX, VIII, VII. X, V, prothrombin, and fibrinogen are clinically significant. • Inhibitors of these factors are clinically significant for bleeding. • Deficiency of Factor XII, and the presence of the lupus anticoagulant are not.
![Coagulation Made Easy The Mixing Study Useful to differentiate etiologies of prolonged clotting Coagulation Made Easy: The Mixing Study • Useful to differentiate etiologies of prolonged clotting](https://slidetodoc.com/presentation_image_h/2c295636da3796a54feeb06994648fae/image-16.jpg)
Coagulation Made Easy: The Mixing Study • Useful to differentiate etiologies of prolonged clotting in a coagulation assay. • Patient’s plasma is mixed 50/50 with normal plasma. Coagulation assay is repeated. • If “substantial” correction is noted after mix, suspect clotting factor deficiency, because you replaced deficient factors in the patient plasma with normal factors from the normal plasma. • If no or not full correction is seen, suspect an inhibitor, because you added the inhibitor (think of this as an anticoagulant) in the patient plasma which inhibits clotting in the normal plasma.
Coagulation made easy
Inductive reasoning vs deductive reasoning geometry
Inductive vs deductive reasoning
Example of a deductive argument
Surgical diathermy machine working principle
Disseminated intravascular coagulation pathophysiology
Capillary method of clotting time
Coagulation profile test
Nécrose de coagulation anapath
Ecchumosis
Clotting factors names
Gelatinisation
Maillard reaction eggs
Coagulation profile test
Separation of serum
Lines of zahn gross
Loading or coagulation