Organ Utilisation Strategy Professor John Forsythe UK Strategy
- Slides: 47
Organ Utilisation Strategy Professor John Forsythe
UK Strategy – Taking Organ Transplantation to 2020 Targets for deceased donors and transplants Target figures to 2020
% of donors Age of UK deceased donors Age
Age of deceased donors – UK vs Spain (2015)
Discard rates for kidneys from deceased donors, 2014 % of retrieved kidneys not transplanted No. kidneys retrieved N= 2986 14754 2432 700 24% overall 19% overall Source: ONT – Spain data, OPTN - US data ANZ - Australia data, NHSBT - UK data 10% overall ¹ 2012 data
Adult DBD kidney offer decline rates EXTENDED CRITERIA Offer decline rates vary from 36% at Leeds to 77% at Leicester STANDARD CRITERIA Offer decline rates vary from 24% at Leeds to 69% at Leicester
Adult elective liver offer decline rates DCD liver Offer decline rates vary from 23% at King’s college to 78% at Newcastle DBD liver Offer decline rates vary from 17% at Birmingham to 70% at Newcastle
Pancreas offer decline rates DCD pancreas Offer decline rates vary from 19% at Guy’s to 94% at Newcastle DBD pancreas Offer decline rates vary from 39% at Guy’s to 71% at Edinburgh and Newcastle
Adult heart offer decline rates Offer decline rates vary from 67% at Papworth to 90% at Newcastle and Harefield
Median waiting time to transplant Upper 95% confidence limit Median Lower 95% confidence limit 14 months 43 months 30 months UK average
Strategy • Length of donation-transplantation process • Support to use of higher risk donor organs • Local MDT process and challenge • Better information • DCD donor assessment • Use of Fast Track/Simultaneous offering www. odt. nhs. uk/odt
DBD donation process 10. 5 hours longer
DCD donation process 8. 5 hours longer
DBD retrieval operation start times Shift in time of day from 2 -5 am to 6 -12 am
Offering and retrieval planning DBD DCD
Post meeting • Stick to referral times • Delay once only • Delay for specified time as maximum • Night-time retrieval? • Streamline donor characterization…. .
Better Information
Reasons for retrieved organs not being transplanted (2015/16) KIDNEY N=276
Reasons for retrieved organs not being transplanted (2015/16) LIVER N=168
Support for Higher Risk Donors
Donors with cod as drug overdose Drug overdose as COD includes deaths from polypharmacy, paracetamol overdose, and alcohol poisoning Slide courtesy of Sarah White, Sydney. Data from NHSBT, ANZOD and OPTN
Support • Sa. BTO advice • Aide memoire • Incidents and events • Consent
INTRODUCTION TO TRANSPLANT APP
Options of diseases to select
Example A Hepatitis C Patient with a UKELD score of 55 What will happen to 100 people like me post-registration
Reasons for decline We send monthly reports to all transplant centres detailing each offer they have received and whether they accepted or declined, with the reason for decline. We indicate whether the organ was transplanted elsewhere. These reports are used in transplant centre MDT meetings and lead to changes in practice.
Challenge • Advisory groups • Named patient allocation • Patient involvement/Consent
DCD donor assessment
DCD donor assessment Referred to SNOD attended Family approached Actual donors Organs Transplanted DBD 1679 1563 1291 783 2604 DCD 5718 3579 2131 496 1132 2014/15 Actual donors of those referred: DBD 47% DCD 9%
DCD donor assessment Review of evidence suggested: • Inconsistent practice by SNODs in handling of DCD referrals • Clinical donor criteria that never resulted in transplantation of donor organs New DCD assessment process agreed with clinical support to improve efficiency in the DCD pathway
DCD donor assessment Potential DCD donors excluded on basis of past non-donation/tx: Regular review and dialogue with clinical community to ensure viable potential donors not missed (as novel technologies come into use)
DCD donor assessment 12 months data (Dec 2015 -Nov 2016) DCD referrals 6182 Absolute contraindication? No 5019 81% Yes 1163 19% DCD exclusion? No 3469 56% Yes 1550 25% SNOD overrides 131 3600 - 58% of our referrals
DCD donor assessment 12 months data (Dec 2015 -Nov 2016) DCD referrals 6182 Absolute contraindication? No 5019 81% Yes 1163 19% No 2260 37% DCD exclusion? No 3469 56% Screening call made to transplant centres Yes 1550 25% SNOD overrides 131 3600 - 58% of our referrals Yes 1340 22% Screening centre decision Acceptable 404 - 30% Not acceptable 936 – 70%
Use of Fast Track offering
Fast Track Offering Schemes • Fast track schemes are designed to maximise the utilisation of organs available for transplantation • Simultaneous offering to speed up allocation • Offers are sent to all eligible centres via SMS, pager or fax • Centres have 45 minutes to respond to the offer via telephone – No response is assumed to be a declined offer – More than one centre accepts - organ allocated to centre highest on list or rota
Trigger points for fast track offering Kidney deemed unsuitable Kidney 5 centres declined donor/organ reasons (3 DCD) Accrued 6 hrs CIT (3 hrs DCD, 12 hrs multi-organ) Pancreas deemed unsuitable Pancreas Liver 4 centres declined donor/organ reasons (3 DCD) Pancreas removed Proposed: after 6 hrs of offering or 3 centres declined for same donor reason At or after cross-clamp the liver is declined/ not yet accepted Heart and lungs First organ offered To be removed within 90 mins At removal or already removed Organs retrieved Organs transplanted Further details can be found in the organ allocation policies available at www. odt. nhs. uk/transplantation/guidance-policies/
% fast tracked (of those donated)
Activity- transplanted N fast tracked: 458 of those fast tracked 428 21 0% 8 0% 77 34% 63% 55% 182 13 15% 37% 31 3%
Introduction of Pancreas Fast Track Scheme Number of pancreases offered 6 times or more has reduced from 23% to 13% Number of offers
Simultaneous Offering • Higher risk donors eg viral risk • Scheme and response requires agreement • Organ specific
Reasons why donation did not proceed following consent/authorisation 7% 7 families 15% families who withdraw because process too long 2015/16 data: 104 DBD families, 546 DCD families 6% 34 families
Enhanced Retrieval response?
Resource
DBD kidney offer decline rates
Summary • Donors becoming more complex and offering taking longer • Many more organs offered than are ever accepted • High offer decline rate with wide centre variation • Reasons for decline reported to centres monthly for review • Much that can be done www. odt. nhs. uk/odt
Acknowledgements Transplant unit, H&I laboratory and other hospital staff and Specialist Nurses for Organ Donation for provision of data to the UK Transplant Registry www. odt. nhs. uk RTSM, February 2017
- Professor john forsythe
- Professor john forsythe
- Sndusrmsg
- Frank forsythe
- Pressors icu
- Promotion from associate professor to professor
- Cell tissue organ organ system organism
- Cells are the building blocks of all living things
- Organ organ penyusun sistem pencernaan
- Organ and organ system
- Tractus respiratorius
- Organ penyusun sistem transportasi
- Principe du microscope polarisant
- Unsw timetable planner
- Include diagramme de cas d'utilisation
- Utilisation present perfect continuous
- Paire torsade
- Utilisation extincteurs
- Capacity utilisation definition
- Verticalisateur paraplégique
- Cas d utilisation
- Diagramme de classe héritage
- Diagramme de cas d'utilisation acteur secondaire
- Citrate utilisation test
- Utilisation des comptes 658 et 758
- Sysml cas d'utilisation
- Langage matlab
- Real estate utilisation
- Citrate utilisation test
- Ccsds pus
- Moteur universel utilisation
- Diagramme des cas d'utilisation technologie
- Cross utilisation of itc
- Pc utilisation
- Manuel utilisation gesform evolution
- Professor john wood
- John l holland
- Feedback hattie effect size
- Professor john hughes
- John stanley temple
- Terry hill framework operations strategy
- Business strategy vs corporate strategy
- Multi domestic strategy
- Chase
- Transnational strategy
- Aligning hr strategy with business strategy
- Integration responsiveness grid
- Crafting and executing strategy in strategic management