MidIR laser imaging for molecular recognition in security

Infra. Sign Revealing the Invisible for a Safer World Mid-IR laser imaging for Molecular

MIRIS – Mid-IR Imaging Spectroscopy Diffuse Reflection Trace Molecules Or Molecular Modifications Laser Camera

§ Security ØTrace HAZMATS & Narcotics § Medical ØFood Safety - Biocontamination Sensor ØPharma

Security 5 Lasers, Optics & Photonics, Oct 7 -9, 2013

SPo. T - Sensitive Picture of Traces 12” 6 Hand-held, battery operated, 9”x 7”x

R AN 9. 25 um Explosive/Binder AN 7. 38 um 9. 5 um HMTD

3 QCLs 9. 5 mm 7. 38 mm DFB FP DFB 7 9. 25

SPo. T raw image results of AN trace on polyethylene Incident beams Absorption R

Validation • First explosive trace imaging system sold for use by US Navy •

Safety & Medical Industrial Plant Safety/TICs 11 Medical Imaging Food Safety Pharmaceutical QC/QA Lasers,

Fundamental Biomolecular Vibrations Proteins Overlap Sugars 12 Fatty Acids Lasers, Optics & Photonics, Oct

Hyperspectral Imaging of Serum Protein ROC Curve Sensitivity PD of 99% Specificity PFA of

Acknowledgements q Pathology Department UCSF q Professor Tarik Tihan, UCSF q Manu Prasanna q

Slides: 14

Download presentation

Mid-IR laser imaging for molecular recognition in security and medical applications Anadi Mukherjee Infra. Sign Fremont, CA Lasers, Optics & Photonics, Oct 7 -9, 2013 Infra. Sign

Infra. Sign Revealing the Invisible for a Safer World Mid-IR laser imaging for Molecular Recognition Security Ø HAZMATs Ø Food Safety Medical Ø Tagless Pathology Ø Pharma QC/QA Hand-held, battery operated system www. infrasign. com 2 Lasers, Optics & Photonics, Oct 7 -9, 2013 Infra. Sign

MIRIS – Mid-IR Imaging Spectroscopy Diffuse Reflection Trace Molecules Or Molecular Modifications Laser Camera Strong fundamental Vibrations (MIR) vs. Weak Overtone (NIR) or Raman l 2 l 3 l 4 Hyperspectral Imaging 3 Lasers, Optics & Photonics, Oct 7 -9, 2013 l 1

§ Security ØTrace HAZMATS & Narcotics § Medical ØFood Safety - Biocontamination Sensor ØPharma - Real-time in-line Quantitative QC/QA ØLaser Pathology - Antibody-free Diagnosis üBody Fluids üTissues – Cancer Biomarkers ØIn-vivo diagnosis/surgery, New Microarrays 4 Lasers, Optics & Photonics, Oct 7 -9, 2013 Infra. Sign

Security 5 Lasers, Optics & Photonics, Oct 7 -9, 2013

SPo. T - Sensitive Picture of Traces 12” 6 Hand-held, battery operated, 9”x 7”x 4”, < 4 lbs Lasers, Optics & Photonics, Oct 7 -9, 2013

R AN 9. 25 um Explosive/Binder AN 7. 38 um 9. 5 um HMTD TNT Urea Nitrate TNT Sugar Urea Nitrate Sugar 8 Lasers, Optics & Photonics, Oct 7 -9, 2013

3 QCLs 9. 5 mm 7. 38 mm DFB FP DFB 7 9. 25 mm

SPo. T raw image results of AN trace on polyethylene Incident beams Absorption R Very thin (cloudy) film of AN on polyethylene film 9 9. 25 um 9. 5 um 6” 7. 38 um 9. 25 um 9. 5 um 7. 38 um Lasers, Optics & Photonics, Oct 7 -9, 2013

Validation • First explosive trace imaging system sold for use by US Navy • Customer quote: “(SPo. T) continues to function well despite the traveling it has done. The hardware has proven to be remarkably robust. ” 10 Lasers, Optics & Photonics, Oct 7 -9, 2013

Safety & Medical Industrial Plant Safety/TICs 11 Medical Imaging Food Safety Pharmaceutical QC/QA Lasers, Optics & Photonics, Oct 7 -9, 2013

Fundamental Biomolecular Vibrations Proteins Overlap Sugars 12 Fatty Acids Lasers, Optics & Photonics, Oct 7 -9, 2013 Infra. Sign

Hyperspectral Imaging of Serum Protein ROC Curve Sensitivity PD of 99% Specificity PFA of 10 -2 (PD of 99%) Anadi Mukherjee et al “Spectroscopic imaging of serum proteins using quantum cascade lasers”, Journal of Biomedical Optics 18(3), 036011 (March 2013). 77 ug/cm 2

Acknowledgements q Pathology Department UCSF q Professor Tarik Tihan, UCSF q Manu Prasanna q Block Engineering – Petros Kotidis q Adtech Optics – Mariano Troccoli q Thor. Labs – John Bruno q Steve Barnett q Quentin Bylund q Biswaroop Mukherjee Thanks 14 Lasers, Optics & Photonics, Oct 7 -9, 2013