FK Technology of Wet Grinding Pharma and Cosmetics
- Slides: 30
FK Technology of Wet Grinding Pharma and Cosmetics 25. - 28. October 2003 Hans Brogli 1 Pharma/Cosmetics
Contents FK u Definition Grinding, Wet Grinding u Characterisation u Modula Grinding Aggregates u Annular Gap Mill Co. Ball-Mill u Applications u Summary 2 Pharma/Cosmetics
Grinding FK We differentiate between: Wet Grinding Dry Grinding u Dispersing 3 Pharma/Cosmetics
Wet Grinding FK Grinding u Crushing of solid matters, crystals or fibres in small parts in a fluid, e. g. active substances, colour pigments 4 Pharma/Cosmetics
Wet Grinding FK Dispersing u destroying of agglomerates, wetting and homogeneous dispersing in a fluid, e. g. toothpaste, lipstick Emulsifying u merging of two not mixable fluids (oil, water) under the effect of shear forces, turbulences and an emulsifier e. g. ointments, body cream 5 Pharma/Cosmetics
Characterisation u Effect of mechanical forces Different products are milled on our mills by impact, pressure, shear forces, cutting or friction u Resistability - hard-elastic, fibrous fruit flesh, coconut flesh, aloe vera plants - hardness of crystalline parts up to mohs hardness 9. 5 6 Pharma/Cosmetics FK
Wet Grinding FK Continuous Mills u Perforated Disc Mills u Toothed Colloid Mill u Corundum Stone Mill u In-Line Homogenizer u Annular Gap Mill Co. Ball-Mill 7 Pharma/Cosmetics
Modula FK “Modula“ The new dimension 8 Pharma/Cosmetics
Grinding Aggregates Mills M/ML, M/MZ, M/MK Open Execution, Outlet open u Feeding with hopper and feeding screw u Feeding with pump In-line Execution Closed Execution, Outlet pipeline u Inlet connected to a tank u Feeding with pump 9 Pharma/Cosmetics FK
Perforated Disc Mill 10 Pharma/Cosmetics FK
Perforated Disc Mill M/ML Crushing, Pre-grinding u Size up to 100 mm u Fineness approx 1 mm The desired fineness is adjusted by the size of the holes in the perforated discs Hole dia. 1. 5 to 20 mm or slotted discs 11 Pharma/Cosmetics FK
Toothed Colloid Mill M/MZ 12 Pharma/Cosmetics FK
Toothed Colloid Mill M/MZ Fine Grinding u Starting size depending on product up to 5 mm u Fineness approx 100 µ The desired fineness is adjustable with u Toothing, coarse, normal, crosswise u Grinding gap infinitely adjustable (gap between rotor and stator) 13 Pharma/Cosmetics FK
Corundum Stone Mill M/MK 14 Pharma/Cosmetics FK
Corundum Stone Mill Finest Grinding u Fineness 30 - 50 µ The desired fineness is adjustable with u Different graining of grinding discs grain 20 to 120 u Grinding gap infinitely adjustable (gap between rotor- and stator disc) 15 Pharma/Cosmetics FK
Modula 16 FK Pharma/Cosmetics
Modula 17 FK Pharma/Cosmetics
Modula - Range 18 FK Type Toothed Colloid Mill Tool Diameter [mm] Drive Capacity [k. W] Throughput [kg/h] M/MZ-80 80 5. 5 100 - 1000 M/MZ-130 15 500 - 5000 M/MZ-150 22 1000 - 10000 M/MZ-190 45 2000 - 20000 M/MZ-250 75 3000 - 40000 Type Corundum Stone Mill Tool Diameter [mm] Drive Capacity [k. W] Throughput [kg/h] M/MK-95 95 5. 5 20 - 200 M/MK-160 11 60 - 800 M/MK-180 11 150 - 1500 M/MK-250 22 300 - 3000 M/MK-300 45 400 - 4000 Type Perforated Disc Mill Tool Diameter [mm] Drive Capacity [k. W] Throughput [kg/h] M/ML-150 5. 5 200 - 2000 Pharma/Cosmetics
Modula M/DIL u Dispersing, crushing of agglomerates u Emulsifying u Exchangeable rotor-, stator elements, different toothing 19 Pharma/Cosmetics FK
Modula M/DIL 20 Pharma/Cosmetics FK
M/DIL - Range FK Type Dis. Ho. Inline Tool Diameter [mm] Drive Capacity [k. W] Throughput based on: Water [l/h] M/DIL-100 7, 5 7000 M/DIL-160 22 40000 M/DIL-180 45 60000 M/DIL-230 200 110 85000 21 Pharma/Cosmetics
Annular Gap Co. Ball Mill 22 Pharma/Cosmetics FK
Processing Co. Ball Mill FK product outlet cooling medium product inlet 23 Pharma/Cosmetics beads outlet
Co. Ball Mill FK Finest grinding down to the Nano range < 0. 5 µ Adjusting Possibilities u Rotor speed u Diameter of grinding beads and grinding gap (rotor). u Material of grinding beads (spec. weight) u Degree of beads filling u Capacity u Product temperature u Product viscosity (contents of dry substances) 24 Pharma/Cosmetics
Co. Ball Mill FK MS-12 MS-50 25 Pharma/Cosmetics
FK Co. Ball Mill Advantages u Narrow grinding gap (four times beads diameter) high energy density narrow grain spectrum u Optimum cooling, all surfaces rotor, stator, lid coolable u Smooth grinding elements resistant to wear, no pins, naps etc. 26 Pharma/Cosmetics
FK Co. Ball Mill u Products from fluid to very viscous can be processed u Cleaning, sterilizing and drying without emptying of grinding beads u Small grinding chamber volume - Little remnants at product change - Quick cleaning, little consumption of cleaning material - Easy and efficient change of products 27 Pharma/Cosmetics
Co. Ball Mill - Range 28 FK Typ MS-12 MS-18 MS-32 MS-50 Rotor diameter (mm) 120 180 320 500 Rotor Driving capacity (kw) 2, 2 - 3 5, 5 - 11 18, 5 - 30 37 - 55 Throughput (l/h) 10 - 40 30 - 80 60 - 300 200 - 1000 Net weight (kg) (approx. ) 160 400 800 1750 Pharma/Cosmetics
Applications FK Pharma suspensions, ointments, veterinary products, eye drops, tablet coating, activesubstances, clotrimazole, betametasone, etc. Cosmetics creams, emulsions, lipstick, nail polish, mascara, eye shadow, titandioxyde, animal skins, shrimp shells, plants, roots, aloe vera etc. 29 Pharma/Cosmetics
Summary FK u All mill types are constructed according to GMP guidelines u All mills can be equipped with CIP, SIP and DIP u Delivery with all qualification documents, possibility of validation u All lubricants with USDA-H 1 admission u For clean rooms all mills can be delivered with water cooled motors (no turbulences) u Products with a viscosity from fluid to highly viscous can be processed u Due to the new modular construction all mills are easy to handle and quickly convertable 30 Pharma/Cosmetics
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