EXCITATION CONTRACTION COUPLING Summary of Mechanics 1 2
- Slides: 12
EXCITATION CONTRACTION COUPLING
Summary of Mechanics 1 2 3 4 5 6 7 Muscles pull; they don’t push Muscle lengthen by being yanked on by antagonists or gravity Muscle force can be graded by recruitment of motor units You activate small motor units first: the size principle Muscle force can be graded by repetitive stimulation Muscle force can be graded by changing length, but who cares Muscle velocity is inversely related to muscle force: you can be strong or fast but not both at the same time 8 Muscle power peaks at 1/3 maximum force 9 Pinnate muscle fibers develop more force at lower velocity because of the angle 10 Muscles fatigue: they drop force on continued use 11 Muscles are heterogeneous based on contractile properties 1 Slow twitch (S) 2 Fast fatigue resistant (FR) 3 Fast Intermediate (FI) 4 Fast fatiguable (FF)
Summary of contractile mechanisms 1 2 3 4 5 6 7 8 9 Muscle cells are highly organized Myofibrils consists of interdigitating hexagonal arrays of filaments Thick filaments are mainly myosin: A bands Thin filaments are actin + tropomyosin + Tn. I + Tn. C + Tn. T: I bands Sliding filaments explains the length-tension curve Cross-Bridge cycling couples ATP hydrolysis to force or shortening Myosin isoforms have different turnover numbers Muscles can be classified by their myosin isoforms Type I (slow twitch) Type IIa (fast twitch oxidative) Type Iib (fast twitch glycolytic) Costameres may transmit force from myofilaments to muscle exterior through the cytoskeleton
The Ca transient trails the muscle action potential and precedes force development
SR release and uptake activities are separate
SR Ca release produces a Ca transient and A-M activation
SR Ca reuptake shuts down A-M interaction
The Ca transient is a switch for A-M activity
Tropomyosin spreads Tn. C control of A-M interaction along the actin filament
Occupancy of Tn. C by Ca trails the Ca transient but precedes force development
The series-elastic model explains twitch time and tetany
Summation of Ca transients allows force to catch up with Tn. C-Ca saturation
- Cardiac excitation-contraction coupling
- Focus figure 9.2 excitation-contraction coupling
- Smooth muscle myosin
- Smooth muscle
- Excitation table for sr flip flops
- Jk excitation table
- Excitation table
- Spread of cardiac impulse
- Orthorpnea
- Sinusoidal excitation
- Coulomb excitation
- Rhythmical excitation of the heart
- Coulomb excitation