Automated Metered Dose Inhaler Presentation 4 032204 Presented
- Slides: 11
Automated Metered Dose Inhaler Presentation #4 (03/22/04) Presented By Group 11: The “MDI Auto-Maniacs” Maria del Carmen Carrillo Jennifer B. Struble Loyrirk Temiyakarn
Problem Definition l Automatic Metered Dose Inhalant (MDI) delivery device: n Electromechanical, in-hospital inhalant drug delivery system n Patients are mechanically ventilated and sedated n Medication delivered automatically as prescribed electronically n Medication must be well shaken (homogenized with propellant)
Background l What is a Metered Dose Inhaler? pocket-sized handheld inhaler n delivers standardized dose of medication for bronchodilation n l Who Uses Them? n l Patients with asthma or chronic obstructive pulmonary disease (COPD) Setting? Critical patients in hospitals n Prescriptions for outpatient or in-home use n
Existing Methods n Methods in-use l n Manual administration Patent Search l Automatic methods are NOT for mechanically ventilated patients
Design Factors l l l Integration with existing endotracheal tubing Homogenization with propellant Delivery of medication into ventilation system Tubing length Synchronization of delivery with breathing Software/Automation n n User interface Prescription error checking
Project Status l Preliminary Research Complete n l Standard MDI Completed Research Endotracheal Tubing Connectors Ventilators (Siemens Servo I) n Types of Medication n l Continuing Research n Homogenizer
Working Design: Using Prefabricated Canisters l Integrated with existing tubing n l Homogenize n l In-line using Aero. Chamber Pneumatic Actuator Laptop-based prescription entry n Similar to error reduction system, Guardrails® Safety Software, in Alaris “Smart” IV Pump
Shaking = Homogenization Key obstacle homogenization l Actuator homogenize and administer Albuterol l n Pneumatic Simple singular directional motion l Control stroke length l Detect position l
Experiment on Homogenization § 1. 2. 3. 4. Overall - Difficult to quantify and so based on subjective analysis Soft vs. Vigorous Shakes Soft more effective Various Vigorous Shakes One worked better than two Various Soft Shakes - Five better than three or ten With the Spacer - ineffective, has to be inhaled to leave the spacer
Timeline l Completed Work Preliminary research n Clearly defined design factors n l Through Innovation Workbench Testing with Albuterol Current Work Discuss with Festo rep. n Order more components to start building prototype n l n Actuator (pneumatic) Building Model A l Timeline n n Order parts ~ immediate Model A ~ End of March Testing ~ End of March Final prototype ~ April l Software included
References l l l l http: //familydoctor. org/040. xml http: //www. medlineplus. com/ http: //www. alarismed. com/na/presskit_ bkgd. shtml http: //www. drgreene. com/21_1377. html http: //www. med. umich. edu/anes/tcpub/glossa ry/anesthesia_glossary-05. htm http: //www. rattus. com/catalogpagesearch 5 ak ent. asp? page=5 Hudson RCI. Ana. Con. Da™ Principles of Operation. 2003