Automated Metered Dose Inhaler Presentation 5 040704 Presented

Automated Metered Dose Inhaler Presentation #5 (04/07/04) Presented By Group 11: The “MDI Auto-Maniacs” Maria del Carmen Carrillo Jennifer B. Struble Loyrirk Temiyakarn

Problem Definition l Automatic Metered Dose Inhalant (MDI) delivery device: n Electromechanical, in-hospital inhalant drug delivery system n Patients are mechanically ventilated and sedated n Medication delivered automatically as prescribed electronically n Medication must be well shaken (homogenized with propellant)

Background l What is a Metered Dose Inhaler? pocket-sized handheld inhaler n delivers standardized dose of medication for bronchodilation n l Who Uses Them? n l Patients with asthma or chronic obstructive pulmonary disease (COPD) Setting? Critical patients in hospitals n Prescriptions for outpatient or in-home use n

Current Issues l Recent Statistics n l 1/25 patients are intubated and mechanically ventilated (1997) Methods in-use l Manual administration l Patent Search l Automatic methods are NOT for mechanically ventilated patients l Patent Number 6, 095, 141

Design Factors l l l Integration with existing endotracheal tubing Homogenization with propellant Delivery of medication into ventilation system Tubing length Synchronization of delivery with breathing Software/Automation n n User interface Prescription error checking

Shaking = Homogenization Key obstacle homogenization l Actuators homogenize and administer Albuterol l n Pneumatic Simple singular directional motion l Set stroke length l Controlled through relays/valves by computer l

Experiment on Homogenization § 1. 2. 3. 4. Overall - Difficult to quantify and so based on subjective analysis Soft vs. Vigorous Shakes Soft more effective Various Vigorous Shakes One worked better than two Various Soft Shakes - Five better than three or ten With the Spacer - ineffective, has to be inhaled to leave the spacer

Project Status l Research completed n n l Ventilators (Siemens Servo I) Ventilation circuits Albuterol canisters Homogenization Parts obtained n Festo pneumatics l l l n l Computer w/ DAQ card Parts still needed n n l Cylinders Valves Tubing Relays Casing/Enclosure Prototype in construction

Working Design: Using Prefabricated Canisters l Integrated with existing ventilation circuit n l Homogenize n l In-line using Aero. Chamber Pneumatic Actuator Computer-controlled Lab. VIEW Prescribe dosage by timer/alarm n Homogenization/actuation sequence programmed n Keeps track of actuations, alerts user before new canister is needed n n

Timeline l Completed Work n n Research Clearly defined design factors l l Through Innovation Workbench n Testing with Albuterol n Obtained Festo parts l Timeline n n Obtain parts ~ on-going Prototype ~ next week Testing ~ next week Final prototype ~ mid-April n Poster creation ~ midlate-April Current Work n Obtain more components for prototype l l n Relays Casing/Enclosure Build prototype l Woo-hoo!

References l l l l http: //familydoctor. org/040. xml http: //www. medlineplus. com/ http: //www. alarismed. com/na/presskit_bkgd. sht ml http: //www. drgreene. com/21_1377. html http: //www. med. umich. edu/anes/tcpub/glossary/anest hesia_glossary-05. htm http: //www. rattus. com/catalogpagesearch 5 akent. asp ? page=5 Hudson RCI. Ana. Con. Da™ Principles of Operation. 2003 http: //www. ahrq. gov/data/hcup/factbk 2. htm