The Danish National Research Foundations Center of Functionally

The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital - DENMARK Neuroscience … and Research Support in a Crossdisciplinary and Cross-Institutional Research Environment Leif Østergaard, MD, MSc, Ph. D, DMed Professor, Director, Danish National Research Foundation’s Center for Funktionally Integrative Neuroscience and the MINDLab Brain/Cognition Initiative Aarhus University / Århus University Hospital

Outline • • The evolution of a Research Group Challenges Critical Needs And a bit of Neuroscience! The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Hvordan virker hjernen? Lange nervefibre fører store mængder information til hjernebarken - kun dele når vores opmærksomhed (i pandelapperene) The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

MR skanner Kroppens atomer er svagt magnetiske I MR-skanneren ensrettes deres felter Blodets iltningsgrad påvirker MR signal styrken (3 -10%) Med et radiosignal drejes felterne. Signalerne som udsendes når de falder til ro . . omregnes i billeder The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital . . og funktion (billedtid 0. 2 -5 sekund)

Biology Theory of Music Neuroscience at CFIN: Sciences and Cultures Meet Physiology Chemistry Anthropology Philosophy Theology Semiotics Mathematics Statistics Psychology Psychiatry Linguistics Neurology Engineering Neurosurgery Computer. Science Physics The Danish National Research Foundation’s Center of. National Functionally Integrative Neuroscience CFIN – The Danish Research Foundation’s Aarhus University / Aarhus University Hospital Center of Functionally Integrative Neuroscience University of Aarhus University Hospital

Danish National Research Foundations Center of Functionally Integrative Neuroscience (CFIN) • Health Sciences § • Sciences § § § § • Anthropologist Semiotist Philosopher Linguist Psychologist Music Theory Support Staff Supported by • Danish National Research Foundation 2001 -2011 • Region Midtjylland § § • • • Dept. Neuroradiology PET-Center University of Aarhus Research Councils EU Royal Academy of Music / Ministry of Culture Private Grants § § § 19 Karen Elise Jensens Fond The John and Birhe Meyer Foundation Velux fonden Lundbeckfonden Trygfonden • Over 150 M DKK (external funding) since 2000 Theology Royal Academy of Music § • Veterinarian Social Sciences § • • 18 Humanities § § • Physicist Mathematician Statistician Chemist Biologist Computer Scientist Engineer Agricultural sciences § • M. D. 18 10 The Danish National Research Foundation’s Center of. National Functionally Integrative Neuroscience CFIN – The Danish Research Foundation’s Aarhus University / Aarhus University Hospital Center of Functionally Integrative Neuroscience University of Aarhus University Hospital

What I need the RSO for § Find funding sources • Search across funding bodies / disciplines • Newletters - courses § Application process • • Specific needs - templates 15% science – 85% ’technicalities’ Budget Scientific writing § Grant administration • • Consortium agreements, negotiations Budgets, fiscal reports, revisions, conflicts Sounding board: Scientists want to do stuff they can’t! Reporting § IP, Tech trans § Sparring • Managing a research group • Funding strategies (institution, grants) • Etc. The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Læger, Teoretiske Fysikere og Statistikere laver ‘Diffusions-mikroskop’ Albert Einstein (2005) <x²> = 2 D Td D 3 10 -9 m²/s v. 37°C: <x²>1/2 17μm (Td = 50 ms) The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Diffusion Imaging in Surgical Planning Eva Vedel Jensen Statistics Mathematics Jesper Frandsen Computer Scientist The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Patient with vascular malformation Suzan Dyve Neurosurgeon Jesper Frandsen Computer scientist Anders Rodell Computer scientist • Mapping the language and motor areas and their ‘wiring’. • Stereotaxic surgery: Vascular malformation removed • Risk of hemorrhage eliminated • Normal motor/sensory function • 24 y/o male with progressing motor loss. • Risk of hemorrhage: Death or disability. • Surgery could damage language and motor ‘wiring’. The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

CFIN Funding strategies Budgets Overview The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Bibliometry Meeting new Public University Funding Algorithms The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

What I need the RSO for § Find funding sources • Search across funding bodies / disciplines • Newletters - courses § Application process • • Specific needs - templates 15% science – 85% ’technicalities’ Budget Scientific writing § Grant administration • • Consortium agreements, negotiations Budgets, fiscal reports, revisions, conflicts Sounding board: Scientists want to do stuff they can’t! Reporting § IP, Tech trans § Sparring • Managing a research group • Funding strategies (institution, grants) • Etc. The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Acute Stroke: Spreading Brain Damage l l l 490. 000 die annually in EU – risk increases exponentially w. age 1. 000 survive, many with severe disabilities Major socioeconomic burden – estimated € 34 Billion The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Ischemic stroke: How and Who to treat? Within 3 hours: Intravenous rt. PA to dissolve blood clots in Ischemic strokes Risk of causing intracranial Hemorrhage! The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Basic Science becomes novel diagnostics – and novel treatments CBF Susceptibilitetskontrast CBV MTT Østergaard, Sorensen, Kwong et al. MRM 36 726 -736 (1996) Livstruende blødning efter trombolyse T 2 DWI Mismatch MTT Vævsdød Dag 5 Sorensen et al Radiology (1999) The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

2004 -2006: Århus Akut Apopleksi Projekt Combining Research and Clinical Implementation of thrombolysis Acute referral (< 2 h) Admission T 2 * DWI MRI 35 min. ICH or ischemia. Migraine? The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital Blood samples Optimized Therapy • I. v. trombolyse • Thrombektomi • Neurorehabilitering • Anden Medicinsk beh. Accelereret diagnose • Kardiologisk udredning • Carotis US • Neurokirurgisk vurdering

Behandling med t. PA startes 122 minutter efter symptomdebut Akut – før t. PA Truet NIHSSS = 14 DV-MR - normal M 1 MCA okklusion NIHSSS = 3 DV-MR - normal 2 timer efter t. PA MTT The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital Niels Hjort, Christine Sølling, Mahmoud Ashkanian

And onwards: EU I-Know project • Stroke groups • Nighoghossian (Lyon) • Fiehler + Thomalla (Hamburg) • Baron (Cambridge) • Pedraza + Serena (Girona) The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital • MR physics • Kiselev (Freiburg) • Industry • e-Health (Systematic) • image analysis software, data mining (Dimac)

What I need the RSO for § Find funding sources • Search across funding bodies / disciplines • Newletters - courses § Application process • • Specific needs - templates 15% science – 85% ’technicalities’ Budget Scientific writing § Grant administration • • Consortium agreements, negotiations Budgets, fiscal reports, revisions, conflicts Sounding board: Scientists want to do stuff they can’t! Reporting § IP, Tech trans § Sparring • Managing a research group • Funding strategies (institution, grants) • Etc. The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Diagnostic Support System: Expert diagnosis - Everywhere Århus University Hospital 111111 -1112 John Doe Infarct Risk 100% Risk factors Diabetes Hypertension Tech Trans and IP is part of Research Support Based on 120 patients 30% EHR The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

What I need the RSO for § Find funding sources • Search across funding bodies / disciplines • Newletters - courses § Application process • • Specific needs - templates 15% science – 85% ’technicalities’ Budget Scientific writing § Grant administration • • Consortium agreements, negotiations Budgets, fiscal reports, revisions, conflicts Sounding board: Scientists want to do stuff they can’t! Reporting § IP, Tech trans § Sparring • Managing a research group • Funding strategies (institution, grants) • Etc. The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Institutional vs. Eksternal Funding The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

MINDLab University Investment Capital Initiative From Gene to God – and God til Gene The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Becoming part of Aarhus University? • 120. 000 DKK over five years • Embed succesfull parts • … I wish! The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Major Equipment Infrastructure € 4. 000 € 400. 000 annual cost Sparring • • • € 20. 000 Private grants Institutional priorities and desicion-making Negotiate overheads The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital € 3. 000 incl. siting € 300. 000 annual costs

What I need the RSO for § Find funding sources • Search across funding bodies / disciplines • Newletters - courses § Application process • • Specific needs - templates 15% science – 85% ’technicalities’ Budget Scientific writing § Grant administration • • Consortium agreements, negotiations Budgets, fiscal reports, revisions, conflicts Sounding board: Scientists want to do stuff they can’t! Reporting § IP, Tech trans § Sparring • Managing a research group • Funding strategies (institution, grants) • Etc. The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital

Take-home • The Brain is cool! • Research Support: Can’t live without it • John Rocks! Thanks for your attention! • Looking for a position with MINDLab? Contact John/me! The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital