Spinoff technologies for cancer diagnosis S Tavernier LIP

Spin-off technologies for cancer diagnosis S. Tavernier, LIP Lisbon Jornadas LIP, April 27, 2015 April 2015 Jornadas LIP 1

Since ≈10 years there is an active program in Lisbon developing spin-off from HE physics in medical imaging, mainly PET. Main activities are - Clear. PEM - Endotof. PET - Dedicated readout electronics for TOF-PET - New Clear. PEM April 2015 Jornadas LIP 2

The Clear. PEM project A dedicated PET scanner for breast imaging April 2015 Jornadas LIP 3

Why? - breast cancer is 3 rd most frequent cancer in humans - one in 10 women eventually develops breast cancer - good survival rate if detected at an early stage April 2015 Jornadas LIP 4

Hamamatsu APD array S 8850 How? - take advantage of the (at that time) new APD photodectors - Use our expertise in using APDs acquired in CMS April 2015 Jornadas LIP 5

The Clear. PEM scanners Clear. PEM (prototype) in Coimbra § Clear. PEM-II in Monza (Italy) 2. 5 mm Spatial resolution : 1. 3 mm 2. 0 mm Obtained with Derenzo phantom (Na 22 rods) § Sensitivity: 2 to 5%, depending on the configuration April 2015 Jornadas LIP 3. 0 mm 1. 2 mm 1. 5 mm 6

In Monza, after one year of upgrade work on the image reconstruction software and user interface, the patient studies with Clear. PEM have resumed very recently. A clinical study (200 patients) will evaluate if FLT (3 -deoxy-3 -[18 F]fluorothymidine) can be used to monitor the stage of the disease reducing the need to perform a biopsies. The performance of Clear. PEM will be compared the one of the standard whole-body PET. April 2015 Jornadas LIP 7

In Coimbra, the team has mainly been using the Clear. PEM as a small animal PET, and evaluating the possibility to use it as a brain. PET. April 2015 Jornadas LIP 8

But we have been overtaken by technological progress APD April 2015 Si. PM Jornadas LIP 9

But we have been overtaken by technological progress APD April 2015 Si. PMs allow for a dramatic improvement in time resolution Jornadas LIP 10

The Endo. TOFPET-US project EU FP 7 project April 2015 Jornadas LIP 11

April 2015 Jornadas LIP 12

Our role in the Endo. TOFPET-US project is to develop the PET Detectors and the readout electronics based on Si. PM readout of the scintillation light. The challenge is to have a highly integrated electronics with low power consumption and the best possible time resolution (≈ 200 ps). April 2015 Jornadas LIP 13

Our new, Si. PM based, front end PET detector based on the TOF PET ASIC allows building the most compact PET detector ever. April 2015 Jornadas LIP 14

And allows building a PET scanner with many 10'000 channels April 2015 Jornadas LIP 15

And the internal probe. . April 2015 Jornadas LIP 16

Should we revisit Clear. PEM? April 2015 Jornadas LIP 17

The situation to avoid. . . Make sure to keep the physician involved from the design phase Hey, I’ve solved your clinical problem I didn’t know I had a problem t s i c i s Physic ia April 2015 n Jornadas LIP 18 18

Thank you for your attention April 2015 Jornadas LIP 19

Backup slides April 2015 Jornadas LIP 20

April 2015 Jornadas LIP 21

Time Of Flight > TOF What if we could measure the time difference very accurately ∆t =1 ns >>> ∆x=15 cm => ! Detector 2 Detector 1 If ∆t ≈10 ps events would be space points ! April 2015 Jornadas LIP 22

Simulation: object D=35 cm, TOF=600 ps, Sensitivity gain factor 3. 9 Karp JS, Surti S, Daube-Witherspoon ME, Muehllehner G. Benefit of time-of-flight in PET, experimental and clinical results: . J Nucl Med 2008; 49(3): 462 -70. April 2015 Jornadas LIP 23

Colon cancer, left upper quadrant peritoneal node 114 kg; BMI=32. 2 ; 13. 4 m. Ci; 2 hr post-inj Images J. Karp, University of Pennsylvania April 2015 Jornadas LIP 24