GLENN CHENEY Senior Manager Technical Communication Pharmanex RD

2 COMPONENTS 1 3 Healthy Eating Daily Activity re. DESIGNin 90 Shakes & Supplements

EAT ONE HEALTHY MEAL Protein Vegetables Fat Dairy Fruits Complex Carbs • F&V –

REPLACE TWO MEALS WITH AC SHAKES Breakfast Lunch Dinner

EFFECT OF A SPECIAL FIBER IN AC SHAKES Too high Without unique fiber Too

EFFECT OF A SPECIAL FIBER IN AC SHAKES Too high Without unique fiber Effect

REPLACETHREE TWO MEALS SNACKSWITH A DAYAC SHAKES 10 -14 nuts ½ apple + 2

1 Healthy Eating Daily 2 3 • 5 ─7× Per Week • Ultimate Goal:

1 Healthy Eating 2 Daily Activity 3 re. DESIGNin 90 Shakes & Supplements

PROVEN INGREDIENTS; THE RIGHT DOSE • Garcinia cambogia fruit extract • Gymnema sylvestre extract

AC COMPLEX AND AC SHAKES TOGETHER: + = 100% Clinically Effective Dose

GREEN TEA STUDIES Green Tea improves Body Composition 90 days; subjects received Green Tea

EFFECTS OF STRESS ON APPETITE High Cortisol Individuals: – Consumed more calories – Ate

+ 63% 40 Treadmill (min) Time to Exhaustion AGELOC VITALITY IMPROVES PHYSICAL ENDURANCE 30

AGELOC VITALITY PRESERVED 57% MUSCLE GLYCOGEN Muscle glycogen (mg/g wet wt. ) COMPARED TO

(RER) Respiratory Exchange Ratio AGELOC VITALITY INGREDIENT PROMOTES FAT METABOLISM DURING PROLONGED EXERCISE Pharmanex

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GLENN CHENEY Senior Manager Technical Communication Pharmanex R&D

re. DESIGNin 90 Weight Management

2 COMPONENTS 1 3 Healthy Eating Daily Activity re. DESIGNin 90 Shakes & Supplements

EAT ONE HEALTHY MEAL Protein Vegetables Fat Dairy Fruits Complex Carbs • F&V – Correlation between F&V consumption and body composition • PROTEIN – for satiety and muscle tone • COMPLEX CARBS – affects rate of energy absorption • FAT – For satiety • DAIRY – correlation between dairy consumption and body composition (also protect against calcium loss)

REPLACE TWO MEALS WITH AC SHAKES Breakfast Lunch Dinner

EFFECT OF A SPECIAL FIBER IN AC SHAKES Too high Without unique fiber Too Low 0 hours 1 hour 2 hours 3 hours 4 hours

EFFECT OF A SPECIAL FIBER IN AC SHAKES Too high Without unique fiber Effect of special fiber in AC Shakes Too Low 0 hours 1 hour 2 hours 3 hours • Unique fiber blend promotes fullness • Balance blood sugar 4 hours • ↓ cravings, so you consume fewer calories

REPLACETHREE TWO MEALS SNACKSWITH A DAYAC SHAKES 10 -14 nuts ½ apple + 2 tsp PB k c k Breakfast a Breakfastn c Lunch na Dinner S k c a n S

1 Healthy Eating 2 3

1 Healthy Eating Daily 2 3 • 5 ─7× Per Week • Ultimate Goal: 1 Hour per day Activity – Break it up into 10 min increments – 10 min × 6 per day = 60 mins – Gradually build up to 60 mins • Don’t pick activities you dislike – Play Wii Sports / “Just Dance” with your kids • Be accountable to yourself & others

1 Healthy Eating 2 Daily Activity 3 re. DESIGNin 90 Shakes & Supplements

PROVEN INGREDIENTS; THE RIGHT DOSE • Garcinia cambogia fruit extract • Gymnema sylvestre extract • Chromium • Forskohlii extract • Lagerstroemia speciosa • Fenugreek fiber EQUIVALENT TO 20 CAPSULES! • • • 4, 700 mg 400 mcg 425 mg 48 mg 2, 000 mg

AC COMPLEX AND AC SHAKES TOGETHER: + = 100% Clinically Effective Dose

GREEN TEA STUDIES Green Tea improves Body Composition 90 days; subjects received Green Tea catechins ↓ intra-abdominal fat (IAF) by 5. 6 cm 2 ↓ in waist circumference Wang H, et al. Effects of catechin enriched GT on body composition. Obesity. 2010 Apr; 18(4): 773 -9. 90 Day RCT of Green Tea 60 subjects: BMI > 25 Week 8: No difference in food intake, or physical activity Δ in resting energy expenditure = 183. 38 k. J/day (p < 0. 001) Week 12: Stress response* significantly ↓ (p < 0. 05) *VMA Auvichayapat et al. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav. 2008 Feb 27; 93(3): 486 -91.

EFFECTS OF STRESS ON APPETITE High Cortisol Individuals: – Consumed more calories – Ate significantly more sweet foods – More negative moods Dietary Restraint = consciously trying to limit food intake to maintain a desired body weight HIGH DIETARY RESTRAINT IS ASSOCIATED WITH HIGH CORTISOL 1. Epel ES, et al. Psychoneuroendocrinology 2001; 26: 37 -49. 2. Mc. Lean JA, Barr SI, Prior JC. Am J Clin Nutr 2001; 73: 7 -12.

+ 63% 40 Treadmill (min) Time to Exhaustion AGELOC VITALITY IMPROVES PHYSICAL ENDURANCE 30 20 10 Week 5 Week 0 Week 5 Control Week 0 age. LOC Vitality

AGELOC VITALITY PRESERVED 57% MUSCLE GLYCOGEN Muscle glycogen (mg/g wet wt. ) COMPARED TO NON-TREATMENT GROUP 2. 0 0. 25 mg/g (-13%) 1. 8 0. 575 mg/g (-30%) 1. 6 1. 4 1. 2 1. 0 Non-Exercise Control Exercise w/ age. LOC Vitality Results from a pre-clinical study in mice with age. LOC Vitality Blend. Ferguson et al. Targeting Mitochondria 2010 Berlin, Germany November 18 -19, 2010.

(RER) Respiratory Exchange Ratio AGELOC VITALITY INGREDIENT PROMOTES FAT METABOLISM DURING PROLONGED EXERCISE Pharmanex ingredient study by Fit Stop Human Performance Laboratory Medicine and Science in Sports and Exercise 2001; 33(5) Supplement 1: pg S 164 1. 05 Carbohydrate Burning Zone 1. 00 Includes: glucose and glycogen 0. 95 0. 90 0. 85 0. 80 Fat burning Zone 0 20 40 Exercise Time (minutes) Before an age. LOC Vitality ingredient 60 After 6 weeks of an age. LOC Vitality ingredient

1 Healthy Eating 2 Daily Activity 3 re. DESIGNin 90 Shakes & Supplements

1 + + = 2 3 = WEIGHT MANAGEMENT SUCCESS