State Research Center of Russian Federation Federal State

State Research Center of Russian Federation Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Obninsk Branch

Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Address: 109 km, Kievskoye Shosse, Obninsk Kaluga Region Telephone: (48439)6 -39 -32, 7 -47 -50 Fax: (48439)6 -39 -11 E-mail: fci@Karpov. IPC. ru Location: 109 km south-west of Moscow Area: more than 70 ha Leading Center of radiation Chemistry in Russia

Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Areas of scientific research and development: - high-energy chemistry; - radiochemistry; - nuclear chemistry and physics; - development of new radiopharmaceuticals; - chemistry of high-molecular weight compounds; - solid state physics; - radiation-chemical technologies; - radiation and space materials technology; - neutron diffraction investigation and dynamics of different class crystals.

Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Up-to-date experimental and technological facilities, including: - nuclear reactor WWR-c; - electron beam accelerators; - powerful radionuclide sources of gamma radiation; - wide range of technological facilities; - testing and research units to investigate organic and inorganic materials in the frames of radiation and space materials technology projects; - experimental-production shop.

Nuclear-chemical technologies

Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» • Leading producer and supplier of radiopharmaceuticals and technetium-99 m generators in Russia. • Karpov’s radionuclide and radiopharmaceutical products are delivered to all Russian clinics. • Development and production of radiopharmaceuticals for diagnostics and therapy are realized as an integrated production cycle

Nuclear reactor or cyclotronbased production of radionuclides Production of radiopharmaceuticals . . Recovery of radionuclides Generator Synthesis of carriermolecules Clinic Labeling Preparation of reagent kits Preparation of radiopharmac euticals

Experimental and production facilities Reactor WWR-c Power – 10 MW Fluence – 5× 1013 n/cm 2·s Number of experimental channels – 31, including 9 horizontal Number of hot cells – 9, each handling 10000 g-equ. Ra Number of heavy chemical boxes - 5

Currently produced radiopharmaceuticals Isotope Chemical form Application Mo-99 T 1/2=66. 02 h Sodium molybdate Technetium-99 m Generator Tc-99 m E =0. 140 Me. V T 1/2=6. 01 h Sodium pertechnetate Technetium-99 m generator Diagnostics with RIA kits Iodine-131 E =0. 365 Me. V T 1/2=8. 04 day Sodium iodide in isotonic solution Thyroid gland, diagnostics and therapy Sodium iodide for injections Thyroid gland, diagnostics and therapy Sodium iodide in capsules Thyroid gland, diagnostics and therapy Ortho-Iodohippurate of sodium Kidney, diagnostics Meta-Iodobenzyl Guanidine Adrenal, diagnostics Samarium oxabiphor Palliative therapy of skeleton Samarium-153 Eβav. =0. 233 Me. V T 1/2=46. 7 h

Currently produced radiopharmaceuticals Isotope Chemical form Ferrum-59 E =1. 2 Me. V T 1/2=44. 5 day “Ferrum Sulphate, 59 Fe 29 k. Bq” Carbon-14 Eβ av. =0. 049 Me. V T 1/2=5730 year T 1/2 bio=2. 5 h Urea-14 C “Ureacaps, 14 C 37 k. Bq” Application Mammary gland, diagnostics` Diagnostics of gastrointestinal diseases: ulcer, malignant tumours

Technetium-99 m generator GMP production line for loading Tc-99 m generators is under construction The design makes it possible to decrease the number of procedures, which ensure operation condition of the generator; -to use light biological shielding; -to install a bactericide filter to obtain aseptic eluate of sodium pertechnetate.

Radiopharmaceuticals being developed For diagnostics of myocardial preinfarction condition Diagnostics of myocardial infarction based on fat phenylmethylpentadecanoic acid labeled with 123 I 99 m. Tc. N-DBODC 5 -heterocomplex composed of PNP 5 and dithiocarbamate ligand Thermoselfcollapsing therapeutical radiopharmaceutica Х = 153 Sm, 188 Re , 90 Y, 117 m. Sn

Items produced by radiation-chemical technology Nuclear-doped semiconductor materials (silicon, gallium arsenide, etc. for power electronics) Radiation-modified minerals (topazes, etc. )

Pilot projects: to build up a facility for Technetium-99 m generator loading in accordance with GMP requirements; – – to build-up an up-to-date facility for radiochemical production of radionuclides and radiopharmaceuticals (investment project developed); – to develop a technology and build up a facility for production of alpha-emitters actinium-225 and radium-223; – to launch molybdenum-99 production from low-enriched uranium targets.

RADIATION CHEMICAL TECHNOLOGIES

Radiation-chemical technologies developed by Karpov Institute curing of paint coatings on the surface of wooden, metallic and gypsum products; products modification of rubber products (tires, etc. ); production of composite materials (binders and prepregs for further manufacturing high-strength and heat-resistant products); modification of polyolefins (production of foamed polyethylene materials and products, hot water supply and heating pipes, gas distribution piping, heat –shrinkable tapes for electric insulation); sterilization of medical products, products drugs, herbal raw material; synthesis of polymer latexes for wall-paper and tanning industry, gel production for perfumery and pharmaceuticals;

Radiation-chemical technologies developed by Karpov Institute Ø Ø Ø monomer grafting onto polymer products (to obtain adhesionbonding surfaces and separation materials for chemical current sources); processing of minerals and microelectronic products (to obtain marketable semi-precious stones and to increase microchip characteristics); destruction of Teflon; radiation-chemical modification of Teflon; production of porous filters (to purify water, air, fuel, aggressive liquids)

Experimental and production facilities УЭЛР-10 -10 -Т-80 in a trench Locally-shielded accelerator “Electron -3 M”

Technological facility for PE cross-linking. Production of foamed polyethylene and heatshrinkable insulation tape.

Technical characteristics of Co-60 γ-facilities, total activity 1490 k. Ci Сo-60 gamma ray facility Activity, k. Ci Max absorbed doze, rad/sec. Irradiator dimensions. mm Raise time, sec. KCB-500 650 550 Ø 90, h=125 180 PARKET 300 170 300 x 100 x 90 240 PX-gamma-30 (Researcher) 20 70 Ø 20, h=20 60 K-120, Build. KU 80 70 Ø 50, h=40 120 K-200 140 200 Ø 30, h=40 120 UGRA 100 250 Ø 30, h=30 0. 5 VULKAN 1 100 250 Ø 50, h=100 0. 5 VULKAN 2 100 250 0. 5

Items produced by radiation-chemical technology Products made from foamed polyethylene sheets

Items produced by radiation-chemical technology Heat-resistant polyethylene pipes Radiation-modified heat-shrinkable items

Items produced by radiation-chemical technology Polyethylene filters To purify: n n n n drinking water, beverages, paints and resins, photoemulsions, water and reagents for microelectronics, magnetic paint, lubricants and cooling liquids. Pore size, m 1 - 100 Total porosity, % 50 -55 Efficiency of water purification from 1 m particles, % 99. 55 O Tmax, C 100

Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» PILOT PROJECTS - center of radiation sterilization and decontamination of medical wastes; - specialized facility for radiation modification of polytetrafluoroethylene