LUNG TRANSPLANTATION Overall 2019 JHLT 2019 Oct 3810

LUNG TRANSPLANTATION Overall 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Lung Transplants Number of Transplants by Year and Location 5000 4000 Other North America Europe 3500 3000 2500 2000 1500 1000 500 0 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 Number of transplants 4500 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide.

Adult and Pediatric Lung Transplants Number of Transplants by Year and Procedure Type 4500 Bilateral/Double Lung 4000 Single Lung 4673 4554 3871 3587 3500 3313 29503027 2813 2584 3000 2500 2000 15131550 1388 1391 1213 1105 1500 1000 2230 2024 1984 1789 1709 1568 924 708 500 0 4293 41814116 3853 408 74 167 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 Number of Transplants 5000 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide.

Adult and Pediatric Lung Transplants Average Center Volume (Transplants: January 2005 – June 2018) Percentage of transplants 60 36 50 30 40 24 30 18 20 46 40 26 10 12 26 22 13 15 0 6 0 1 -4 5 -9 10 -19 20 -29 30 -39 40 -49 Average number of lung transplants per year 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 50+ % of Transplants (red line) Number of Centers Number of centers

Adult and Pediatric Lung Transplants Average Center Volume by Location (Transplants: January 2010 – June 2018) 60 Other Number of Centers 50 North America Europe 40 7 30 20 10 3 13 9 6 21 13 13 8 12 7 8 1 -4 5 -9 13 10 0 10 -19 20 -29 1 1 30 -39 2 7 13 5 6 40 -49 50+ Average number of lung transplants per year 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Lung Transplants 11 -17 18 -34 35 -49 50 -59 60 -65 66+ Median age 100% 80 80% 64 60% 48 40% 32 20% 16 0% 0 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 1 20 7 18 % of Transplants 0 -10 Median recipient age (years; blue line) Recipient Age by Year (Transplants: January 1988 – June 2018) Year of Transplant 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Lung Transplants Donor Age by Year (Transplants: January 1988 – June 2018) 18 -34 35 -49 50 -59 60 -65 66+ Median age 100% 60 80% 48 60% 36 40% 24 20% 12 0% 0 Year of Transplant 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 Median donor age (years; blue line) 11 -17 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 1 20 7 18 % of Transplants 0 -10

Adult and Pediatric Lung Transplants Donor and Recipient Age (Transplants: January 2010 – June 2018) Donor Age (Years): 0 -10 11 -17 18 -34 35 -49 50 -59 60 -65 66+ 100% % of Transplants 80% 60% 40% 20% 0% 0 -10 11 -17 18 -34 35 -49 50 -59 Recipient Age (Years) 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 60 -65 66+

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group (Transplants: January 1992 – June 2017) 100 Adult (N = 63, 410) Pediatric (N = 2, 223) Survival (%) 75 p = 0. 0894 50 25 Median survival (years): Adult = 6. 2; Pediatric = 5. 7 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group and Transplant Type (Transplants: January 1992 – June 2017) 100 Adult/Primary (N=60, 885) Adult/First Retx (N=2, 407) Pediatric/Primary (N=2, 076) Pediatric/First Retx (N=141) Survival (%) 75 All pairwise comparisons were significant at p < 0. 05 except for Adult/Primary vs. Pediatric/Primary and Adult/First Retx vs. Pediatric/First Retx. 50 25 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group Conditional on Survival to 1 Year (Transplants: January 1992 – June 2017) 100 Adult (N=48, 511) Pediatric (N=1, 675) Survival (%) 75 p = 0. 0088 50 25 Median survival (years): Adult = 8. 3; Pediatric = 9. 1 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group and Transplant Type Conditional on Survival to 1 Year (Transplants: January 1992 – June 2017) 100 Adult/Primary (N=46, 866) Adult/First Retx (N=1, 572) Pediatric/Primary (N=1, 589) Pediatric/First Retx (N=82) Survival (%) 75 No pairwise comparisons were significant at p < 0. 05 except for Adult/Primary vs. Adult/First Retx and Adult/First Retx vs. Pediatric/Primary. 50 25 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

N - Adult N - Pediatric 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 % - Adult Year of Transplant % - Pediatric 200 40 175 35 150 30 125 25 100 20 75 15 50 10 25 5 0 0 Retransplant % of All Transplants within Age Group (lines) 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 19 Number of Retransplants (bars) Adult and Pediatric Lung Retransplants by Year and Age Group