LUNG TRANSPLANTATION Overall 2017 JHLT 2017 Oct 3610

LUNG TRANSPLANTATION Overall 2017 JHLT. 2017 Oct; 36(10): 1037 -1079

Adult and Pediatric Lung Transplants Number of Transplants by Year and Procedure Type 4000 Bilateral/Double Lung 3500 Single Lung 3869 3852 3587 3309 29493023 2809 2582 3000 2500 2228 2018 1979 1785 1708 151215481566 1389 1391 1213 1104 921 2000 1500 1000 708 500 0 417640984218 408 5 7 35 74 167 19 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 2099 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 15 Number of Transplants 4500 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide.

Adult and Pediatric Lung Transplants Average Center Volume (Transplants: January 2004 – June 2016) Percentage of transplants 60 36 50 30 40 24 30 18 20 43 41 31 12 30 10 19 9 14 0 6 0 1 -4 5 -9 10 -19 20 -29 30 -39 40 -49 Average number of lung transplants per year 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 50+ % of Transplants (red line) Number of Centers Number of centers

Adult and Pediatric Lung Transplants Average Center Volume by Location (Transplants: January 2004 – June 2016) 60 Other Number of Centers 50 North America Europe 5 40 12 3 30 20 8 22 15 11 15 10 14 0 16 9 7 2 4 3 30 -39 40 -49 50+ 16 8 0 1 -4 5 -9 1 12 10 -19 20 -29 Average number of lung transplants per year 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 4

Adult and Pediatric Lung Transplants Average Center Volume by Location (Transplants: January 2009 – June 2016) 60 Other Number of Centers 50 North America Europe 40 8 30 11 3 5 22 20 9 11 10 8 1 -4 5 -9 1 10 13 9 0 12 15 10 -19 20 -29 11 10 2 6 3 30 -39 40 -49 50+ 0 Average number of lung transplants per year 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 6

Adult and Pediatric Lung Transplants 11 -17 18 -34 35 -49 50 -59 60 -65 66+ Median age 100% 80 80% 64 60% 48 40% 32 20% 16 0% 0 19 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 16 % of Transplants 0 -10 Median recipient age (years; blue line) Recipient Age by Year (Transplants: January 1987 – June 2016) Year of Transplant 2017 JHLT. 2017 Oct; 36(10): 1037 -1079

Adult and Pediatric Lung Transplants Donor Age by Year (Transplants: January 1987 – June 2016) 18 -34 35 -49 50 -59 60 -65 66+ Median age 100% 60 80% 48 60% 36 40% 24 20% 12 0% 0 Year of Transplant 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 Median donor age (years; blue line) 11 -17 19 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 16 % of Transplants 0 -10

Adult and Pediatric Lung Transplants Donor and Recipient Age (Transplants: January 1990 – June 2016) Donor Age: 0 -10 11 -17 18 -34 35 -49 50 -59 60 -65 66+ 100% % of Transplants 80% 60% 40% 20% 0% 0 -10 11 -17 18 -34 35 -49 Recipient Age 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 50 -59 60 -65 66+

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group (Transplants: January 1990 – June 2015) 100 Adult (N = 55, 607) Pediatric (N = 2, 107) Survival (%) 75 p = 0. 1141 50 25 Median survival (years): Adult = 5. 9; Pediatric = 5. 4 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2017 JHLT. 2017 Oct; 36(10): 1037 -1079

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group and Transplant Type (Transplants: January 1990 – June 2015) 100 Adult/Primary (N=53, 396) Adult/First Retx (N=2, 119) Pediatric/Primary (N=1, 964) Pediatric/First Retx (N=137) Survival (%) 75 All pairwise comparisons were significant at p < 0. 05 except for Adult/Primary vs. Pediatric/Primary and Adult/First Retx vs. Pediatric/First Retx 50 25 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2017 JHLT. 2017 Oct; 36(10): 1037 -1079

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group Conditional on Survival to 1 Year (Transplants: January 1990 – June 2015) 100 Adult (N=42, 427) Pediatric (N=1, 573) Survival (%) 75 p = 0. 0113 50 25 Median survival (years): Adult = 8. 1; Pediatric = 8. 8 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2017 JHLT. 2017 Oct; 36(10): 1037 -1079

Adult and Pediatric Lung Transplants Kaplan-Meier Survival by Age Group and Transplant Type Conditional on Survival to 1 Year (Transplants: January 1990 – June 2015) 100 Adult/Primary (N=41, 013) Adult/First Retx (N=1, 360) Pediatric/Primary (N=1, 492) Pediatric/First Retx (N=77) Survival (%) 75 No pairwise comparisons were significant at p < 0. 05 except for Adult/Primary vs. Adult/First Retx and Adult/First Retx vs. Pediatric/Primary 50 25 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Years 2017 JHLT. 2017 Oct; 36(10): 1037 -1079

Adult and Pediatric Lung Retransplants N - Pediatric % - Adult % - Pediatric 50 10 25 5 0 0 2017 JHLT. 2017 Oct; 36(10): 1037 -1079 20 20 20 04 20 20 20 19 19 Year of Transplant 14 15 12 75 10 20 08 100 06 25 02 125 00 30 98 150 96 35 94 175 92 40 90 200 19 Number of Retransplants (bars) N - Adult Retransplant % of All Transplants within Age Group (lines) Retransplants by Year and Age Group