HEART TRANSPLANTATION Overall 2019 JHLT 2019 Oct 3810

HEART TRANSPLANTATION Overall 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Heart Transplants Number of Transplants by Year and Location 6000 5000 4500 Other North America Europe 4000 3500 3000 2500 2000 1500 1000 500 0 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 Number of transplants 5500 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of heart transplants performed worldwide.

Adult and Pediatric Heart Transplants Average Center Volume (Transplants: January 2010 – June 2018) Percentage of transplants 140 70 120 60 100 50 123 80 40 60 30 40 20 66 59 57 20 22 0 1 -4 5 -9 10 -19 20 -29 30 -39 10 6 40 -49 8 4 50 -74 75+ Average number of heart transplants per year 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 0 % of transplants Number of centers

19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 % of transplants 0 -9 10 -17 18 -39 40 -59 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 60 -69 70+ 120% 60 100% 50 80% 40 60% 30 40% 20 20% 10 0% 0 Median recipient age (years) Adult and Pediatric Heart Transplants Recipient Age by Year of Transplant Median Age

19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 Median recipient age (years) Adult and Pediatric Heart Transplants Median Recipient Age by Location Europe North America 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 Other 60 55 50 45 40

19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 % of transplants 0 -9 10 -17 18 -39 40 -59 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 60 -69 70+ 120% 35 100% 30 80% 25 20 60% 15 40% 10 20% 5 0% 0 Median donor age (years) Adult and Pediatric Heart Transplants Donor Age by Year of Transplant Median Age

19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 Median donor age (years) Adult and Pediatric Heart Transplants Median Donor Age by Location Europe North America 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 Other 50 45 40 35 30 25 20

Adult and Pediatric Heart Transplants Recipient Age Distribution by Era 70 1988 -1998 (N=49, 528) % of transplants 60 50 1999 -2009 (N=46, 576) 2010 -6/2018 (N=42, 198) 40 p<0. 0001 30 20 10 0 0 -9 10 -17 18 -39 40 -59 Recipient Age (Years) 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 60 -69 70+

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2010 – June 2018) Donor Age (Years): 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of transplants 80% 60% 40% 20% 0% 0 -9 10 -17 18 -39 40 -59 Recipient Age (Years) 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 60 -69 70+

Adult and Pediatric Heart Transplants Donor and Recipient Age (Transplants: January 2010 – June 2018) Recipient Age (Years): 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of transplants 80% 60% 40% 20% 0% 0 -9 10 -17 18 -39 40 -59 Donor Age (Years) 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 60 -69 70+

Adult and Pediatric Heart Transplants Recipient Age Distribution by Location (Transplants: January 2010 – June 2018) 0 -9 Age (Years): 10 -17 18 -39 40 -59 60 -69 70+ 100% % of recipients 80% 60% 40% 20% 0% Europe North America 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 Other Recipient age (years): mean/median Europe = 47/52; North America = 46/53; Other = 44/48

Adult and Pediatric Heart Transplants Donor Age Distribution by Location (Transplants: January 2010 – June 2018) Age (Years): 0 -9 10 -17 18 -39 40 -59 60 -69 70+ 100% % of donors 80% 60% 40% 20% 0% Europe North America 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 Other Donor age (years): mean/median Europe = 40/44; North America = 29/27; Other = 32/31

Adult and Pediatric Heart Transplants Kaplan-Meier Survival (Transplants: January 1992 – June 2017) 100 Median survival = 11. 9 years; Median survival conditional on surviving to 1 year = 14. 2 years Survival (%) 75 50 N = 114, 783 25 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Years 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Heart Transplants Kaplan-Meier Survival by Age Group (Transplants: January 1992 – June 2017) 100 Adult (N=102, 005) Pediatric (N=12, 654) Survival (%) 75 p<0. 0001 50 25 Median survival (years): Adult=11. 5; Conditional=13. 9; Pediatric=18. 1; Conditional=22. 3 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Years 2019 JHLT. 2019 Oct; 38(10): 1015 -1066