HEARTLUNG TRANSPLANTATION Overall 2019 JHLT 2019 Oct 3810

HEART-LUNG TRANSPLANTATION Overall 2019 JHLT. 2019 Oct; 38(10): 1015 -1066

Adult and Pediatric Heart-Lung Transplants Number of Transplants Reported by Location and Year 300 North America 250 Europe 200 150 100 50 0 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 1 20 6 17 Number of Transplants Other 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 NOTE: This figure includes only the heart-lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of heart-lung transplants worldwide has declined in recent years.

Adult and Pediatric Heart-Lung Transplants Average Center Volume (Transplants: 2005 – June 2018) Percentage of transplants 70 70 60 60 50 50 40 40 30 67 20 30 20 39 10 10 0 1 2 8 4 3 4 -9 Average number of heart-lung transplants per year 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 0 % of Heart-Lung Transplants (red line) Number of Centers Number of centers

Adult and Pediatric Heart-Lung Transplants Distribution of Transplants by Lung Center Volume (Transplants: 2005 – June 2018) % of Heart-Lung Transplants 30 25 20 15 10 5 0 1 -4 5 -9 10 -19 20 -29 30 -39 40 -49 Average number of lung transplants per year 2019 JHLT. 2019 Oct; 38(10): 1015 -1066 50+

Adult and Pediatric Heart-Lung Transplants Kaplan-Meier Survival by Age Group (Transplants: 1992 - June 2017) 100 Median survival (years): Adult = 4. 5, Pediatric = 3. 6 Conditional median survival (years): Adult = 11. 2, Pediatric = 8. 4 Survival (%) 75 p = 0. 6199 50 25 Adult (N=2, 829) Pediatric (N=447) 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Years 2019 JHLT. 2019 Oct; 38(10): 1015 -1066