Cardiac ion channels i Voltage gated ii Ligand
- Slides: 21
Cardiac ion channels: i. Voltage gated ii. Ligand gated b) Nodal tissue- RMP & AP Action potential m. V 0 ICa. L -40 -60 ICa. T Pacemaker potential IK
m. V SYMPATHETIC STIMULATION: 0 -60 Sympathetic stimulation m. V PARASYMPATHETIC STIMULATION: 0 -60 Vagal stimulation
3) CONDUCTIVITY: i. SA node: ii. Internodal pathways: iii. AV node: iv. Bundle of HIS: v. Purkinje fibres:
i. SA (SINO-ATRIAL) NODE: Transtitional cells P - cells
SA node
ii. INTERNODAL PATHWAYS: • Anterior internodal tract: • Middle internodal tract: • Posterior internodal tract:
SA node Internodal pathways Anterior Middle Posterior
SA node Internodal pathways Anterior Middle Posterior AV node
iii. AV (ATRIO-VENTRICULAR) NODE: N AN NH HIS bundle
iv. BUNDLE OF HIS: • Left bundle branch: • Right bundle branch:
SA node Internodal pathways Anterior Middle Posterior AV node HIS bundle Rt. branch Lt. branch
v. PURKINJE FIBRES: SA node Internodal pathways Anterior Middle Posterior Purkinje fibres AV node HIS bundle Rt. branch Lt. branch
Conduction speeds of different parts (m/sec) Rate of discharge of impulses (impulses/sec) Time taken for impulse to travel different tissues: 0. 03 sec SA node 0. 13 sec AV Bundle branches node 0. 03 sec Purkinje fibers Ventricular endocardial & epicardial surfaces
STEPS IN SPREAD OF ELECTRICAL ACTIVITY: 1. Atrial activation: 2. Septal activation: 3. Activation of: Ventricular myocardium- anteroseptal portion Ventricular myocardium-major portion 4. Late activation of: Left ventricle-posterobasal portion Pulmonary conus Uppermost portion of septum
1. Atrial activation: SA node AV node
A-V nodal delay • Duration – • Cause for the delay – • Significance of the delay – • Effect of drugs • Regulation of A-V conduction: Vagal stimulation Sympathetic stimulation
2. Septal activation: SA node AV node
3 (a) Activation of anteroseptal region of ventricular myocardium SA node AV node
3 (b). Activation of major portion of ventricular myocardium SA node AV node
4. Late activation of : Posterobasal portion of left ventricle Pulmonary conus & septal uppermost portion SA node AV node
SA AV
- Ligand and voltage gated channels
- Ligand gated ion channels
- Patch clamp amplifier axon
- Distribution of gated channels on a neuron
- Metabotropic receptor
- Depolarization sodium ions
- The movement in and out of cells
- Ion channels
- Facilitated diffusion ion channels
- Step voltage and touch voltage
- Rms output voltage
- Power formula three phase
- Converting rms to peak
- Introduction to high voltage technology
- Ion dipolo
- C6h12 fuerza intermolecular
- Qué son las fuerzas intramoleculares
- London forces vs van der waals
- Ligan heksadentat
- Aktivni transport
- Ml6 mo diagram
- Werners theory of coordination compounds