Clinical Features Of Neoplasia Clinical Features Of Neoplasia

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Clinical Features Of Neoplasia

Clinical Features Of Neoplasia

Clinical Features Of Neoplasia • Effects of Tumor On Host • Grading & Clinical

Clinical Features Of Neoplasia • Effects of Tumor On Host • Grading & Clinical Staging Of Cancer • The Laboratory Diagnosis of Cancer

Effects of Tumor On Host • Tumor Impingement on nearby structures – Pituitary adenoma

Effects of Tumor On Host • Tumor Impingement on nearby structures – Pituitary adenoma on normal gland---compression of normal tissue ----Hypopitutrism – Pancreatic carcinoma on bile duct-----Produce fatal billiary tract obstruction – Renal artery leiomyoma-------ischemia & hypertention – Hormones production-----B cell tumor produce hyperinsulinism – Ulceration/bleeding – Colon, Gastric, and Renal cell carcinomas • Infection (often due to obstruction) – Pulmonary infections due to blocked bronchi (lung carcinoma), Urinary infections due to blocked ureters (cervical carcinoma) • Rupture or Infarction – Ovarian, Hepatocellular, and Adrenal cortical carcinomas; Melanocarcinoma metastases

Effects of tumor on host • Cancer Cachexia • Paraneoplastic Syndromes – Endocrinopathies –

Effects of tumor on host • Cancer Cachexia • Paraneoplastic Syndromes – Endocrinopathies – Neuromyopathies – Osteochondral Disorders – Vascular Phenomena – Fever – Nephrotic Syndrome

PARANEOPLASTIC SYNDROMES Symptom complexes other than cachexia that appear in patients with cancer and

PARANEOPLASTIC SYNDROMES Symptom complexes other than cachexia that appear in patients with cancer and cannot be readily explained either by the local or distal spread of the tumor or by the elaboration of hormones indigenous to the tissue of origin of the tumor. Occur in 10 -15% of tumors