Visual processing pathways Ungerleider et al 1998 Organization

Visual processing pathways Ungerleider et al. , 1998

Organization and strength of cortical inputs to the hippocampus Suzuki and Amaral, 1994

Hierarchical organization of the ventral visual stream Van. Rullen, 2003

Schematic representation of the ventral visual pathway Rousselet et al. , 2004

Distributed semantic model Patterson et al. , 2007

Semantic hub model Patterson et al. , 2007

Semantic dementia (SD) - stroke - Herpes simplex virus encephalitis - Alzheimer’s disease - fronto-temporal dementia (semantic variant) Patterson et al. , 2007

Patterson et al. , 2007

Patterson et al. , 2007

Differences between semantic dementia and Alzheimer’s disease in measures of semantic memory 1 minute to list as many examples of a semantic category as they can Pyramids and Palm Trees test of semantic association Patterson et al. , 2007

Differences between semantic dementia and Alzheimer’s disease in measures of brain hypometabolism regions (18 F)fluoro‑ 2 - deoxy‑D -glucose positron emission tomography (FDG-PET) Patterson et al. , 2007

Rostral temporal lobes are ‘hard-to-get’ Positron emission tomography (PET) Functional MRI (f. MRI) Magnetoencephalography (MEG) Voxel-based morphometry (T 1‑weighted MRI)

Hub model: ATL regions as being crucial for semantic processing, or … “To paraphrase a recently-departed United States Secretary of Defense, we do not believe that the seeming absence of evidence constitutes, in this case, evidence of absence. “

ATL activation in functional imaging studies of semantic processing Patterson et al. , 2007

ATL activation in functional imaging studies of semantic processing Patterson et al. , 2007

Thank you for your attention