NIDAs New HIVAIDS Research Program Jacques Normand Ph

NIDA’s New HIV/AIDS Research Program Jacques Normand, Ph. D. Director, AIDS Research Program National Institute on Drug Abuse

Objectives • Update on NIDA’s New AIDS Research Program – CAMCODA – NIDA Council Recommendations – New AIDS Research Program – Structure – Research Priorities • Brief Update on NIDA/NIH Collaborative Projects – Projects and Partners – New HPTN Network Drug Abuse Projects

CAMCODA Structure Director Deputy Director Medical Consequence Unit Human Development Unit Staff: 20 Professionals Population. Based Intervention Unit

NIDA AIDS FY 03 AIDS Funding by Divisions CAMCODA 116, 035, 000 DESPR 57, 707, 000 DTR&D 54, 204, 000 DNBR 29, 615, 000 CTN 12, 052, 000

NIDA Advisory Council Workgroup on HIV/AIDS Report on Findings and Recommendations February, 2004

Structural & Procedural Recommendations • Create new position of “Director, AIDS Research Program” reporting to NIDA’s Director • Update policy/procedures to determine which projects qualify for AIDS funding • Improve articulation of HIV/AIDS mission and planning process within & across Divisions/Centers • Increase interaction across NIH, and with extramural community

NIDA’s AIDS Research Program Structure AIDS Research Program Mission: Plan, develop, coordinate and integrate research priorities within NIDA and externally. Staff: Jacques Normand Lynda Erinoff Helen Cesari AIDS Workgroup AIDS Coding Subgroup External Scientific AIDS Workgroup TBA

NIDA’s AIDS Workgroup Membership Division of Pharmacotherapies and Medical Consequences of Drug Abuse Jag Khalsa Ahmed Elkashef Jamie Biswas Division of Basic Neurosciences and Behavioral Research Diane Lawrence Cora Lee Wetherington Charles Sharp Yu Lin Minda Lynch

NIDA’s AIDS Workgroup Membership (Cont. ) Division of Epidemiology, Services, and Prevention Research Elizabeth Lambert Division of Clinical Neurosciences, Development and Behavioral Treatment Lisa Onken Melissa Racioppo Nicolette Borek Ro Nemeth Center for Clinical Trials Network Mary Ellen Michel

NIDA’s AIDS Workgroup Membership (Cont. ) Office of Science Policy & Communication Anna Staton International Program Steve Gust Intramural Research Program John Schmittner Office of Extramural Affairs Mark Green Office of Planning & Research Management Stacy Gardner

External Scientific AIDS Workgroup Proposed Membership (~ 8): Council Members Nominee per Division/Center Nominee from AIDS Program Proposed Task: Review NIDA’s AIDS Strategic Plan Review & make recommendations on new AIDS related procedural change (e. g. , definition of AIDS and coding guidelines) Review NIDA’s priorities/initiatives

FY 04 AIDS Funding by NIDA Divisions DPMC 52, 046, 000 DESPR 121, 656, 000 DCNDBT 46, 336, 000 DBNBR 29, 374, 000 CCTN 11, 557, 000

NIDA’s FY 04 Funding By OAR Research Areas of Emphasis 1. 2. 3. 4. 5. 6. Natural History and Epidemiology Etiology and Pathogenesis Therapeutics Vaccines Behavioral and Social Science Training, Infrastructure, and Capacity Building 7. Information Dissemination $54, 246, 859 $29, 028, 598 $12, 084, 141 $1, 983, 201 $186, 583, 465 $6, 860, 742 $1, 594, 994

Research Priority Recommendations Update programs with continuous review of epidemiologic and other findings Racial/ethnic disparities Emphasize case finding/treatment HAART interactions/adherence/resistance Newer HIV/IDU epidemics (Russia, China, India, Eastern Europe) Test drug Tx for HIV prevention Emerging drugs (e. g. , Meth/Viagra, NYC case/immunological & CNS impact ) Sexual risk behaviors (main exposure category) Adolescents (developmental/decision making, impulsivity) Role of drug abuse on transmission (drug type, partnership, context)

Current NIDA’s AIDS Program Tasks • Explore new ways to attract new AIDS PIs • Better integrate HIV/AIDS within and across NIDA Divisions/Centers and other NIH Institutes • Working on Generating FY 07 OAR Priorities (retooling priorities to establish strong presence in all Div/Ctr) • Will be Generating NIDA FY 06 AIDS Initiatives • Developing Criteria for AIDS Grants • Will be Appointing Members to Extramural Scientific AIDS Workgroup • Will be Developing NIDA’s HIV/AIDS Strategic Plan

NIDA’s Collaborative Projects Network/Cohort Collaborating ICs NIDA’s Co-Fund Adolescent Trial Network NICHD, NIMH Pediatric HIV AIDS Cohort Study NICHD, NIAID, NIMH $3. 0/12. 0 M Centers For AIDS Research NIAID, NCI, NHLBI, & NIMH $1. 0/20. 0 M $4. 6/33. 3 M Women Interagency NIAID, NICHD, & NCI $0. 5/18. 5 M HIV Study HIV Prevention Trial Network NIAID, NIMH, NICHD, $4. 4/70. 0 M & FIC

HPTN & New NIAID Network • Current Projects Epidemiology HIV Prevention Drug Tx as HIV Prevention • New Network Proposed protocols Community Scale-up; Stimulant pharmacotherapy as HIV prevention