History of Neurology EDWARD PEIRSON RICHARDSON JR MD

History of Neurology EDWARD PEIRSON RICHARDSON JR MD (1918 -1998) MARCH 27 TH, 2017 NEUROLOGY RESIDENT MORNING REPORT

EDWARD PEIRSON RICHARDSON JR MD • • • (1918 -1998) From a long line of HMS scholars/faculty – Father & Paternal Grandfather Chiefs of MGH surgery – Mother: Clara Lee Shattuck; he was the 6 th Shattuck physician & Shattuck street is where HMS is located. Harvard 1939; HMS 1943 Served in WWII as a physician 1944‐ 46 MGH 1946 Res Pysch under Dr. Stanley Cobb 1947‐ Queens Square Neurology & Maudsley Hosp for Psychiatry @ Queen Square‐exposed to Dr. J. Goodwin Greenfield Neuropathology 1949 @ MGH Asst to Dr. Charles Kubik Neuropathology 1951‐Neuropathology lab director, till 1989 Worked with Adams, Miller Fisher, Castlemen, & Victor Continued to work until a few months before his death from lymphoma Bullard Professor of Neuropathology 1984

EDWARD PEIRSON RICHARDSON JR MD (1918 -1998) • MGH residents all did 1 year Neuropathology for many years & were trained by EPR • He taught Neuropathology course at HMS for 2 nd year med students with RD Adams MD & Alfred Pope MD – Also taken by all Neuropathology trainees. (Neurology and Path residents) • Frequent contributor to Pathology section of NE Journal of Medicine & CPCs • Led Neuropathology teaching sessions/brain cutting during Tuesday evening conferences Neurology. 1967; 17(8 Pt 2): 22‐ 5

EDWARD PEIRSON RICHARDSON JR MD MAJOR CONTRIBUTIONS • • • Progressive Multifocal Leukoencephalopathy – Papers 1961 & 1988 – Described what was then a new entity Corticobasal Degeneration Arch Neurol 1968; 18: 20‐ 33 The myelopathy of pernicious anemia. A neuropathological reappraisal. Acta Neurol Scand. 1968; 44: Suppl 5: 1‐ 36. Granulomatous angiitis of the central nervous system: protean manifestations and response to treatment 1988; 51(9): 1126– 1133. Granulomatous angiitis of the central nervous system. Arch Neurol 1968; 19: 510‐ 524, The neurological manifestations of systemic lupus erythematosus Medicine 1968 Jul; 47(4): 337‐ 69. Pathogenesis and evolution of periventricular leukomalacia in infancy. Arch Neurol 1972; 27: 229‐ 236 Adreno‐leukodystrophy (Sex‐Linked Schilder Disease)Ultrastructural Demonstration of Specific Cytoplasmic Inclusions in the Central Nervous System Arch Neurol 1972; 27; 458‐ 460 Adrenoleukodystrophy: A clinical and pathological study of 17 cases. Arch Neurol 1975; 32: 577‐ 591 Hallervorden‐Spatz syndrome Arch Neurol. 1974 Jan; 30(1): 70‐ 83. Subacute diencephalic angioencephalopathy. J Neurol Sci 1974; 22: 197‐ 210,

EDWARD PEIRSON RICHARDSON JR MD MAJOR CONTRIBUTIONS • • • Spinal epidural abscess N Engl J Med. 1975 Sep 4; 293(10): 463‐ 8. Hypoxic‐Ischemic Leukoencephalopathy in Man Arch Neurol. 1976; 33(1): 5‐ 14 Subacute Spongiform Encephalopathy (Creutzfeldt‐Jakob Disease Brain 1978 101 (2): 333‐ 344 Subacute encephalomyelitis of AIDS and its relation to HTLV‐III infection Neurology 1987; 37: 562‐ 569 Selective sparing of a class of striatal neurons in Huntington's disease. Science 1985; 230; 561‐ 563 Neuropathological classification of Huntington's disease J Neuropathol Exp Neurol 1985; 44; 559‐ 577 Clinical and neuropathologic assessment of severity in Huntington's disease Neurology 1988; 341‐ 347 Pathology of the Peripheral Nerve (1995) The Neurologic Illness of Eugene O'Neill N Engl J Med 2000; 343: 741‐ 742

Letter Written for Dr. Barohn from EP Richardson

Pictures from Tyler Library RD Adams MD E. P. Richardson MD C Miller Fisher, MD Harvey Cushing MD

Elliot Richardson (1920 -1999) Who was Elliot Richardson? ? A. B. C. D. Former President of Harvard Former Secretary of State Former Attorney General EP Richardson's Father Answer: Former Attorney General 1973

Elliot Richardson: What is he known for? 1: Allowed minority students in Harvard 2: Helped President Kennedy in Cuban Missile Crises 3: Fired by President Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor 4: Nothing Answer: Fired by Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor Also EP Richardson’s Brother