ANTI ADRENERGIC DRUGS ANTI ADRENERGIC DRUG ACTION PRODUCED

ANTI ADRENERGIC DRUGS ANTI ADRENERGIC DRUG. ACTION PRODUCED BY THIS DRUG ARE TOTALLY OPPOSITE TO ADRENALINE OR ADRENERGIC DRUG CAN BLOCK IN FOLLOWING WAYS: . DRUG CAUSING DEPLETION OF CATECHOLAMINES FROM VARIOUS BODY TISSUE Eg- RESERPINE. . DRUG WHICH INTERFERE WITH THE SYNTHESIS IN ADRENERGIC NERVE OR ADRENALINE GLAND. Eg- METHYL DOPA. . DRUG WHICH INTERFERE WITH TRANSMISSION OF IMPULSE ACROSS POST GANGLIONIC NEURON. Eg- GUANETHIDINE. . DRUGS BLOCKING ALPHA OR BETA RECEPTOR BOTH.

CATECHOLAMINES DEPLETORS. RESERPINE SHOWS ITS EFFECT BY PREVENTING THE REPEATED OF ADRENALINE OR NOR ADRENALINE CAUSING ITS DEPLETION. . THEREFORE IT CAUSE IN HYPERTENSION AND PSYCHATRICS. . HOWEVER DUE TO DEPLETION OF CATECHOLAMINES RESERPINE MAY CAUSE DEPRESSION LEADING TO SUICIDAL TENDANCY THEREFORE IT IS NO LONGER USE IN HYPERTENSION.

ALPHA METHYL DOPA. It prevent synthesis of nor adrenaline by entering the neurone instead of nor adrenaline being form alpha methyl. Nor adrenaline is formed which is inactive

ALPHA AND BETA BLOCKERS 1 ) ALPHA BLOCKERS : Alpha blockers block the alpha receptor. They are classified into – A)Beta haloalkyl amines – eg. Phenoxybenzamine B) Natural and dihydrogenated ergot alkaloids - eg. ERGOTOXIN C) Imidazole derivatives – eg. Tolazoline D) miscellaneous - eg. dibenzazepine 2 ) BETA BLOCKERS : A) B) C) D) They blocks beta receptors and are classified into specific beta blockers - eg. Timolal Beta blockers with membrane stablizing activity – eg. Propranalol Beta blockers with membrane stablizing activity and inrinsic sympathomimatic activity - eg. Dichloroisoprenalin Beta blocker with additional alpha blocking activity – eg. Lebetalol

USES OF ALPHA & BETA BLOCKERS A ) ALPHA BLOCKER – 1. Pentolamine is use in the treatment of pheochromocytoma 2. tolazoline is use in the treatment of peripheral vascular diseases such as raynaud’s disease 3. ergotamine is used in the treatment of migraine B ) BETA BLOCKERS – 1. Hypertention 2. angina pectories 3. cardiac arrhythmia 4. pheochromocytoma

ANTI ADRENALGIC DRUGS CREATED BY : 1) SHAIKH AKIL 2) SHAIKH SHAKEEL 3) SHAIKH AAQUIB 4) SHAIKH AADIL 5) SHAIKH MUHAMMAD GUIDENCE BY : MS. SYEDA SHAHANA