Study The Effects of Green Tea camellia sinensis

Study The Effects of Green Tea (camellia sinensis ) on Serum Malondialdehyde and Glutathione Concentration on High Cholesterol Fed Rats Suaad M. J. Al-Hadrawy*, Najat Mutar Oraibi Al salami** *Assistant Professor Dr. / University of kufa/ Faculty of Sciences/ Department of Biology **Associate Professor Dr. /University of kufa/ Faculty of Medicine Abstract Discussion In recent years great interest has emerged in studying the health benefits of green tea particularly in relation to cardiovascular disease and cancer. We therefore evaluated health aspects of green tea on the body antioxidant and oxidative stress biomarkers also their special effects on body weight and body weight gain under prolonged high cholesterol diets in White rats. . Conclusions: These data indicate that green tea supplementation resulted in elevated serum glutathione and decrease serum malondialdehyde. The green tea reduced the blood lipid and body weight gain. …………………………………………………………………………… ………………………………………. . Introduction Green tea is an one kind of tea that is prepared from Camellia sinensis grasses that have not experienced the similar oxidation and … withering process used to construct black teas and other types of teas. The cultivation of green tea created first in China, but its creation and produce has increase to various another countries in Asia. Numerous varieties of green tea be present, which differ largely based on horticultural methods, the diversity of Camellia sinensis used, growing conditions, time of harvest and production processing (Khan and Mukhtar, 2013). Despite numerous claims about the health effects of Camellia sinensis. Specialized medical research on human has not given definite evidence of these benefits (Boehm et al. , 2009; Khan and Mukhtar, 2013). A team of scientists in 2010 published a study on the claims for health benefits at the demand of the European Commission: in overall they suggest that the claims made for green tea were not reinforced by enough scientific confirmation. Even though the mean content of catechins and flavonoids in a mug of green tea is greater than that in the similar size of further drink and foodstuff matter that are considered to be of health benefit, catechins and flavonoids have no confirmed biological consequence in humans (EFSA, 2010). 1. Contact Dr. Suaad M. J. Al-Hadrawy University of kufa/ Faculty of Sciences/ Department of Biology 2. 3. 4. 5. Results in this study revealed a significant increase (P 0. 05) of serum malondialdehyde concentration in animals group treated with high cholesterol diets in comparison with other groups, while the results exhibited a significant decrease (P 0. 05) in concentration of serum malondialdehyde in animals group treated with grean tea in comparison with other groups. …. . Several human and animals studies recommended that green tea consumption has good effects in reducing oxidative stress (Bhatt et al. , 2010). Also, antioxidative properties of green tea and its catechins content have also been proven in many in-vivo studies. Skrzydlewska et al. proved that green tea catechins contents of dietary supplementation with green tea can decrease MDA concentration as a biochemical marker of lipid peroxidation and advance whole antioxidant capacity, in the rat’s brain, blood and liver, (Skrzydlewska et al. , 2002). In the study of Quine and Raghu exhibited that epicatechin treatment at dose of 15 and 30 mg/Kg in diabetic rats resulted in a significant reduce in MDA concentrations (Quine and Raghu, 2005). In a study by Patil and Balaraman (2011) they proved that green tea decreases iron-prompted lipid peroxidation in lung cells as well as brain homogenates and cultured C 6 astrocytes. Results in the figure (2) revealed a significant decline (P 0. 05) of the serum glutathione concentration in animals group treated with high cholesterol diets, while the results indicated a significant rise (P 0. 05) in concentration of serum glutathione in animal group treated with grean tea and animal group treated with cholesterol + grean tea. The results of this study agreed with the results of other studies that proved that green tea consumption will up-regulate antioxidant factors (non-enzymatic and enzymatic). In a study by Moskaug and his group, they proved that nutritional polyphenols have been recognized as powerful antioxidants, and moreover have been shown to up- regulate the synthesis of glutathione peroxidase and glutathione action in the cells, and attenuate mitochondrial oxidative stress (Moskaug et al. , 2005). Green tea (Camellia sinensis) has gained significant interest as an important antioxidant source amongst the common sources of polyphenol-rich beverages and foods, and has also been shown to decrease the dangers for cardiovascular disease and to ease features of the metabolic syndrome (Phung et al. , 2010). References Bhatt PR, Pandya KB and Sheth NR (2010): CAMELLIA SINENSIS (L): THE MEDICINAL BEVERAGE: A REVIEW. International Journal of Pharmaceutical Sciences Review and Research. Volume 3, Issue 2, July – August 2010; Article 002. Skrzydlewska E, Ostrowska J, Farbiszewski R and Michalak K (2002): Protective effect of green tea against lipid peroxidation in the rat liver, blood and the brain. Phytomed. 9: 232 -238. Patil L and Balaraman R (2011): Effect of Green Tea Extract on Doxorubicin Induced Cardiovascular Abnormalities: Antioxidant Action. Iranian Journal of Pharmaceutical Research, 10 (1): 89 -96.