Scenario 1 Diagnostic No PCI Required Left Coronary

Scenario 1: Diagnostic No PCI Required Left Coronary Artery (LCA) Right Coronary Artery (RCA) LCX 50 mm RCA 65 mm GC GC LAD 70 mm Total Eligible Length (excludes stents & borders) = ~185 mm Suspected Index Culprit Lesion: Prox LAD Unblinded Run: LAD Index Non-Culprit Artery: RCA, LCX Blinded Run(s): LCX, RCA PCI Performed: No PCI performed = Suspected Index Culprit Lesion = Unblinded Scan = Treated Segment; scanned but not included in analysis = Blinded Scan = Guide Catheter = 5 mm excluded stent border XXXXX= Stent 1

Scenario 2: Single Lesion PCI LCA GC RCA LAD GC 45 mm LCX RCA 60 mm 50 mm Total Eligible Length (excluding stent & borders) = ~155 mm Suspected Index Culprit Lesion: RCA Unblinded Run: RCA Index Non-Culprit Artery: LAD, LCX Blinded Run(s): LCX, LAD PCI Performed On: Prox RCA = Suspected Index Culprit Lesion XX GC Exclude 5 mm borders = Blinded Scan = Guide Catheter = Unblinded Scan = Treated Segment; scanned but not included in analysis XXX = 5 mm excluded stent border XXXXX = Stent RCA 50 mm 2

Scenario 3: Chronic Total Occlusion RCA LCA GC RCA GC CTO LAD 35 mm LCX 55 mm RCA Total Eligible Legth (exluding stents & borders) = ~90 mm Suspected Index Culprit Lesion: RCA Unblinded Run: RCA Index Non-Culprit Artery: LAD, LCX =Suspected Index Culprit Lesion Blinded Run(s): LCX, LAD = Unblinded Scan PCI Performed On: Prox RCA = Treated Segment; scanned but not included in analysis RCA GC GC = Blinded Scan = Guide Catheter = 5 mm excluded stent Exclude 5 mm borders border XXXXX = Stent 3

Scenario 4: Ramus Present LCA RCA GC LAD 45 mm GC RCA 70 mm LCX Ramus 55 mm 20 mm Total Eligible Length (excluding stent & borders)= ~190 mm Suspected Index Culprit Lesion: Prox LCX Unblinded Run: LCX Index Non-Culprit Artery: LAD, RCA, Ramus Blinded Run: LAD, RCA, Ramus PCI Performed On: No PCI performed = Suspected Index Culprit Lesion = Unblinded Scan = Treated Segment; scanned but not included in analysis = Blinded Scan = Guide Catheter = 5 mm excluded stent border XXXXX = Stent 4

Scenario 5: Multi Lesion PCI RCA LCA GC GC LAD 25 mm Total Eligible Lengh (excluding stent & borders)= ~75 mm Suspected Index Culprit Lesion: LAD, RCA Unblinded Run: LAD, RCA Index Non-Culprit Artery: Prox RCA Blinded Run: N/A PCI Performed On: Prox RCA and Prox/Mid LAD RCA 50 mm = Suspected Index Culprit Lesion Exclude 5 mm borders = Unblinded Scan XX GC LAD GC 25 mm XX XX XX = Guide Catheter XX XXX = Treated Segment; scanned but not included in analysis = Blinded Scan Exclude 5 mm borders = 5 mm excluded stent border XXXXX = Stent RCA 50 mm 5

Scenario 6: Prior Stenting LCA GC RCA GC X XX LAD 35 mm Exclude 5 mm borders RCA LCX 15 mm 40 mm Total Eligible Length (exluding stent & borders) = ~90 mm Suspected Index Culprit Lesion: LAD, RCA Unblinded Run: LAD, RCA Index Non-Culprit Artery: LCX Blinded Run: LCX PCI Performed On: No PCI = Suspected Index Culprit Lesion = Unblinded Scan = Treated Segment; scanned but not included in analysis = Blinded Scan = Guide Catheter = 5 mm excluded stent border XXXXX = Stent 6

Scenario 7: Single Lesion PCI and Ramus LCA RCA LAD Ramus 35 mm RCA 80 mm LCX 40 mm Exclude 5 mm borders LAD XX XXX LCX 40 mm 25 mm Total Eligible Length (excluding stent & borders)= ~180 mm Suspected Index Culprit Lesion: LAD Unblinded Run: LAD Index Non-Culprit Artery: LCX, RCA, Ramus Blinded Run: LCX, RCA, Ramus PCI Performed On: Prox LAD Ramus = Suspected Index Culprit Lesion 35 mm = Unblinded Scan = Treated Segment; scanned but not included in analysis = Blinded Scan = Guide Catheter = 5 mm excluded stent border XXXXX= Stent 7